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Malcolm White

@mfwhite2.bsky.social

Molecular microbiologist at the University of St Andrews, Scotland. My scientific interests include: CRISPR, antiviral defence, cyclic nucleotide signalling, archaea, nucleases.

1,078 Followers  |  191 Following  |  108 Posts  |  Joined: 23.10.2023  |  2.0543

Latest posts by mfwhite2.bsky.social on Bluesky

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Plasmid streamlining drives the extinction of antibiotic resistance plasmids under selection for horizontal transmission Conjugative plasmids play an important role in the spread of antimicrobial resistance (AMR) genes among pathogenic bacteria. This study shows that AMR loss in evolving populations is associated with t...

Our story on plasmid streamlining is now published in PLoS Biology! With @andrewmatthews.bsky.social and @sonjalehtinen.bsky.social
#MicroSky #Mevosky
journals.plos.org/plosbiology/...

12.12.2025 12:09 β€” πŸ‘ 35    πŸ” 20    πŸ’¬ 2    πŸ“Œ 0

In Scotland, we are familiar with Bams

11.12.2025 13:48 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Because freedom of speech is curtailed in Europe πŸ€”

10.12.2025 16:44 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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The top 10 people of 2025 @nature.com who shaped science.
Recognizes Dr. Susan Monarez, the CDC Director who was "fired for holding the line on scientific integrity"
www.nature.com/immersive/d4...

08.12.2025 17:05 β€” πŸ‘ 344    πŸ” 97    πŸ’¬ 6    πŸ“Œ 3

AI protein design marches on - very cool.

09.12.2025 09:25 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Diversity is a good thing - can we still say that?

09.12.2025 09:21 β€” πŸ‘ 6    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

yet more depressing craziness

08.12.2025 16:04 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Phages are full of genes of unknown function that are likely adaptive in specific conditions.
New preprint: Phage TnSeq identifies essential genes rapidly and knocks all non-essentials. We would like to send a pool of phiKZ mutants to anyone wanting it! Reach out
tinyurl.com/bdcfrejh

08.12.2025 15:04 β€” πŸ‘ 87    πŸ” 40    πŸ’¬ 1    πŸ“Œ 2

I used to do this with courgettes to annoy my kids

05.12.2025 06:46 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Fascinating, take a look at the thread

05.12.2025 06:42 β€” πŸ‘ 9    πŸ” 4    πŸ’¬ 0    πŸ“Œ 0

A great opportunity for aspiring PhD students

02.12.2025 09:58 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

THE conference of 2026. Very glad to hear there's a zoom option, as I ain't setting foot in the USA in the next 3 years.

02.12.2025 09:54 β€” πŸ‘ 11    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Our SPARHA story is out in Nature Communications!
doi.org/10.1038/s414...
We investigated a new short pAgo-HNH defense system, showing that it assembles into filaments degrading cellular DNA, inducing abortive infection, resolved their structure, and uncovered the activation mechanism 🧡

01.12.2025 08:38 β€” πŸ‘ 16    πŸ” 5    πŸ’¬ 1    πŸ“Œ 0
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The Biology of Nucleus-Forming Jumbo Phages Nucleus-forming jumbo bacteriophages display a surprisingly intricate replication cycle inside of bacterial host cells, challenging the long-standing paradigm of prokaryotic simplicity. The phage nucl...

The Biology of Nucleus-Forming Jumbo Phages
#phage #phagesky

www.annualreviews.org/content/jour...

29.11.2025 04:08 β€” πŸ‘ 17    πŸ” 4    πŸ’¬ 0    πŸ“Œ 0

@multidefence.bsky.social

27.11.2025 09:14 β€” πŸ‘ 1    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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a man walking in a field with an umbrella ALT: a man walking in a field with an umbrella

Come join us! Soon I will be advertising a postdoc vacancy in my group as part of my @erc.europa.eu AdG project 'DARK ROOTS'. Focus of the project will be on phylo- and metagenomic mining of novel prokaryotic lineages. I will soon post a link here - stay tuned, and please repost! #asgardarchaea

26.11.2025 15:39 β€” πŸ‘ 32    πŸ” 31    πŸ’¬ 0    πŸ“Œ 1

My lab is hiring postdocs! We combine AI, protein structure prediction and comparison, and high-throughput virology to study the virus-host conflict.

You can read more about my lab's research here: jasonnomburg.com/research/

Apply here to join us in lovely Vienna! aithyra.onlyfy.jobs/job/0khkxp82

20.10.2025 13:03 β€” πŸ‘ 14    πŸ” 9    πŸ’¬ 1    πŸ“Œ 0

Hot, but very cool!

26.11.2025 06:44 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Now online at @cp-cellhostmicrobe.bsky.social from co-first authors @erinedoherty.bsky.social & @jnoms.bsky.social

25.11.2025 21:14 β€” πŸ‘ 10    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
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Directed evolution of phages in biofilms enhances Pseudomonas aeruginosa control through improved lipopolysaccharide recognition - Nature Communications Phage therapy holds potential against Pseudomonas aeruginosa chronic lung infections in cystic fibrosis patients. Here, the authors demonstrate that biofilm heterogeneity limits phage effectiveness an...

www.nature.com/articles/s41...

21.11.2025 08:45 β€” πŸ‘ 17    πŸ” 5    πŸ’¬ 0    πŸ“Œ 0
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Intracellular competition shapes plasmid population dynamics From populations of multicellular organisms to selfish genetic elements, conflicts between levels of biological organization are central to evolution. Plasmids are extrachromosomal, self-replicating g...

Hot off the press! Our latest paper led by @fernpizza.bsky.social, understanding how plasmids evolve inside cells. These small, self-replicating DNA circles live inside bacteria and carry antibiotic resistance genes, but also compete with one another to replicate. 1/
www.science.org/doi/10.1126/...

20.11.2025 21:42 β€” πŸ‘ 431    πŸ” 200    πŸ’¬ 11    πŸ“Œ 18
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🚨Preprint alert - this is a big one! We transfer the revolutionary power of TnSeq to bacteriophages.

Our HIDEN-SEQ links the "dark matter" genes of your favorite phage to any selectable phenotype, guiding the path from fun observations to molecular mechanisms.

A thread 1/8

20.11.2025 20:39 β€” πŸ‘ 210    πŸ” 89    πŸ’¬ 11    πŸ“Œ 5
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Is it a flagellate? A tiny ball with tentacles? Contamination in my ciliate culture? NEW SUPERGROUP OF EUKARYOTES? Yes to all 4! Meet Solarion - just out in #Nature doi.org/10.1038/s415... Huge congrats to Marek Valt, Cepicka Lab & the star team! Very happy to be part of this project. #ProtistsOnSky

19.11.2025 21:38 β€” πŸ‘ 116    πŸ” 47    πŸ’¬ 5    πŸ“Œ 0
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EASTBIO: When Phages Collide: Understanding How Multiple Prophages Shape Bacterial Behaviour at University of St Andrews on FindAPhD.com PhD Project - EASTBIO: When Phages Collide: Understanding How Multiple Prophages Shape Bacterial Behaviour at University of St Andrews, listed on FindAPhD.com

🚨 PhD opportunity! 🚨
Join us at St Andrews to study how multiple prophages shape bacterial behaviour & AMR.
Co-supervised with @tatianadimitriu.bsky.social
This is a competition-based EASTBIO PhD.
Full details and the application link are in the advert πŸ‘‡
www.findaphd.com/phds/project...

17.11.2025 15:13 β€” πŸ‘ 9    πŸ” 12    πŸ’¬ 0    πŸ“Œ 2

PhD studentship opportunity! Join us at St Andrews to study the factors controlling plasmid transmission in the gut. Competition-funded as part of the EASTBIO DTP, co-supervised with Dr Jaclyn Pearson. Please share & pass on to anyone interested! 🦠🧫 Deadline 15th DecemberπŸ‘‡

18.11.2025 11:41 β€” πŸ‘ 12    πŸ” 19    πŸ’¬ 0    πŸ“Œ 0
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Building bridges – People – EMBO Meet Aude Bernheim, Institut Pasteur, Paris | EMBO Young Investigator

Meet Aude Bernheim @audeber.bsky.social, EMBO Young Investigator at @pasteur.fr #France: β€œThe EMBO Young Investigator Programme has been developed by and for researchers,” she says. β€œIt gives us access to some of the best #research infrastructures in the world.” πŸ§ͺ www.embo.org/people/build...

18.07.2025 14:09 β€” πŸ‘ 18    πŸ” 3    πŸ’¬ 0    πŸ“Œ 0

Akin to bacterial SIR2 antiphage proteins, human SIRal, also known as FAM118b, forms filaments that are essential for its NAD processing activity.

Awesome to see structures of these filaments that differ from bacterial ones.

Congrats to the authors on this beautiful study.

17.11.2025 16:52 β€” πŸ‘ 16    πŸ” 3    πŸ’¬ 1    πŸ“Œ 0

Just been trying out Nature Research Assistant beta, which analyses your manuscript drafts and suggests "improvements". Strong sub-editor vibes for me and I worry it will homogenise the literature - anyone else had a look?

17.11.2025 09:11 β€” πŸ‘ 4    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0

Amazing piece of work from @rtoshiro.bsky.social
& Kim Seed at UC Berkeley. πŸ™Œ
Played a tiny role in this work.

Surviving phage attack dynamically regulates bacterial immunity to defeat counterdefenses

www.biorxiv.org/content/10.1...

15.11.2025 15:37 β€” πŸ‘ 16    πŸ” 5    πŸ’¬ 1    πŸ“Œ 0
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Recurrent acquisition of nuclease-protease pairs in antiviral immunity Antiviral immune systems diversify by integrating new genes into existing pathways, creating new mechanisms of viral resistance. We identified genes encoding a predicted nuclease paired with a trypsin...

Our nuclease-protease story is out! We explored a fascinating case of coevolution and modularity in prokaryotic immune systems: www.science.org/doi/10.1126/...

Thanks to wonderful coauthors/collaborators/friends, the whole @doudna-lab.bsky.social and everyone at @innovativegenomics.bsky.social

13.11.2025 22:15 β€” πŸ‘ 80    πŸ” 35    πŸ’¬ 5    πŸ“Œ 4

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