Leonard Frach

Very exciting preprint by @axel-schmidt.bsky.social, @kuludwig.bsky.social and team!
Check out Kerstin's thread for overview

Very exciting preprint by @axel-schmidt.bsky.social, @kuludwig.bsky.social and team!
Check out Kerstin's thread for overview

Genetic impacts on within-pair DNA methylation variance in monozygotic twins capture gene-environment interactions and cell-type effects Background Genetic variants that are associated with phenotypic variability, or variance quantitative trait loci (vQTLs), have been detected for multiple human traits. Gene-environment interactions ca...

New preprint by Xiaopu Zhang!
www.biorxiv.org/content/10.1...
@jordanatbell.bsky.social @ntrbiopsy.bsky.social

🔔Paper alert! Extremely excited to share a preprint from our lab! Spearheaded by @axel-schmidt.bsky.social, a super talented medical & computational geneticist, we studied latent Epstein-Barr virus (EBV) infection at population-scale.

Interested in how this works & what we found? Read along! 👇

Our project, looking at the genetic relationships between immune diseases and psychiatric disorders, has finally been published! Now with gene expression analyses as well as additional sensitivity analyses, thanks to reviewers. Find the full article here: www.nature.com/articles/s41...

PHD Position at the Department of Developmental and Educational Psychology (m/f/d)

PhD position in my group at @fau.de, as part of my @erc.europa.eu Consolidator project PAR2. German is not essential but an interest in social science genetics would be great! Sharing would be much appreciated ❤️

www.jobs.fau.de/jobs/phd-pos...

Design and model choices shape inference of age-varying genetic effects on complex traits Understanding how genetic influences on complex traits change with age is a fundamental question in genetic epidemiology. Both cross-sectional (between-subject) and longitudinal (within-subject) appro...

🚨New preprint is out!

How do genetic effects on complex traits change with age? In this work, we compare different approaches to obtain age-varying genetic effects, and show how design and modeling choices can impact the conclusions we draw.
shorturl.at/17snd
A thread 🧵👇

A network of metabolites and their potential causal relationships. Green edges are Detected by the statistical causal inference method MR-link-2

Our paper, MR-link-2 has just been published! Offering pleiotropy robust Mendelian randomization from a single region! www.nature.com/articles/s41...

The Contribution of Common and Rare Genetic Variation to Emotional and Behavioural Symptoms in Childhood and Adolescence Genetic factors influence vulnerability to common mental health conditions, but their role in early-life mental health remains understudied. We analysed genotype array and exome sequence data from two...

New preprint!🚨
"“The Contribution of Common and Rare Genetic Variation to Emotional and Behavioural Symptoms in Childhood and Adolescence” is out on medRxiv.
www.medrxiv.org/content/10.1...

Thread 👇

While the world watches Israel's war with Iran, Netanyahu's extremist government continues to starve and massacre Palestinians in Gaza.

Today, Israeli forces again opened fire on people desperately trying to collect food aid, killing dozens. Over 56,000 have been killed so far.

Intergenerational Transmission of Parental Mental Health and Wellbeing Traits on Offspring Emotional and Behavioural Difficulties https://www.medrxiv.org/content/10.1101/2025.06.17.25329751v1

Looking for your next research position? We're recruiting two genetic epidemiologists to work on two projects at the Division of Psychiatry at UCL, part of the growing UCL Human Genomics group.

Thanks @eivindy.bsky.social! My first foray into the mysterious world of #SelectionBias. Very happy to receive feedback, and to discuss opportunities for improving/expanding this work!

Productive week @eivindy.bsky.social!
Glad to see this one out @chrisrayner.bsky.social, super useful!

🧵 THREAD: Preprint from @chrisrayner.bsky.social reveals how to fix selection bias in the Norwegian #MoBa study using population-wide registry data! For the first time, we can quantify and adjust for selection bias in this major epidemiological resource.

Spread the good news!
osf.io/preprints/os...

First Singapore for a conference followed by AUS!

Treemap showing measurement fragmentation across subfields in psychology. Hill-Shannon Diversity 𝐷=1626.05

How often measures in the APA PsycTESTS database are (re)used according to the APA PsycInfo database: rarely, the majority are never reused.

Our fragmentation index (Hill-Shannon diversity) over time across subdisciplines shows fragmentation rising.

Our paper "A fragmented field" has just been accepted at AMPPS. We find it's not just you, psychology is really getting more confusing (construct and measure fragmentation is rising).
We updated the preprint with the (substantial) revision, please check it out.
osf.io/preprints/ps...

Congrats Sarah!?!
I went on a bigger trip and actually got a tattoo while travelling lol (not PhD related though)

Last week, our new paper on indirect assortative mating was published.🍾 Let’s take a closer look at what this means, why it matters, and what we found (🧵/32):

www.nature.com/articles/s41...

@perlinedemange.bsky.social is this us?

1/13 New preprint out! We developed methods to test a key assumption in family-based genetic studies: that siblings don’t genetically influence each other’s traits. Spoiler: mostly they don’t, but there’s a twist with ADHD ratings at age 3 👶
osf.io/preprints/ps...

Looking forward to running a session alongside @tommetherell.com @zefreeman.com on the challenges of public engagement in a post-truth society during #SIPS2025 in Budapest! Hope to see you there for an open and informative discussion!

🎓 Multiple exciting job openings at the Department of Complex Trait Genetics at VU Amsterdam:

Application for Two PhD Positions in Statistical Genetics: t.co/0Cy3KF75lI
Application for Postdoc Statistical Genetics: t.co/ENI5KeI6yF
Application for Postdoc Bioinformatics: t.co/qOLaauKNLV

Not a button, but you can add -ai at the end of your search (although you probs know that already?)

@selimsametoglu.bsky.social TwinLife has got personality data (BFI-S) for twins and their parents. www.twin-life.de/documentation/
There's also genotype data available, currently ~750 independent genotyped trios, probs a bit more in the future. Lmk if you need more info!

FIMM-EMBL Group Leaders in Molecular Medicine FIMM-EMBL Group Leaders in Molecular Medicine

We have 2-3 group leader positions opening @fimm-uh.bsky.social !!

We are looking for outstanding candidates in human genetics and precision medicine.

This time we have a focus on population health data science. E.g. AI for EHR/health data       

Generous starting package 💰

shorturl.at/FAk6n

New paper with @paulhufe.net Astrid Sandsør and Nicolai Borgen 📝
Causal evidence for gene-environment interaction based on:
🧬 Exogenous within-family genetic differences
🏫 Exogenous variation in school value added

Genome-wide association studies in a large Korean cohort identify quantitative trait loci for 36 traits and illuminate their genetic architectures - Nature Communications Here the authors identify hundreds of genetic loci linked to 36 traits in East Asians, revealing population-specific associations and emphasizing the importance of diverse ancestry groups in genome-wi...

Now published! Congrats Yon Ho on this huge lift conducting dozens of GWAS in Korea and performing meta-analyses with other Asian biobanks reaching a sample size comparable to UK Biobank. The fine-mapping, novel loci, and ancestry-enriched discoveries are very cool. www.nature.com/articles/s41...

The UK Biobank mental health enhancement 2022: Methods and results Background This paper introduces the UK Biobank (UKB) second mental health questionnaire (MHQ2), describes its design, the respondents and some notable findings. UKB is a large cohort study with over ...

Very pleased to see our paper describing the @ukbiobank.bsky.social second online mental health questionnaire has now been published in @plosone.org! This describes the origin of the resource as well as the data.

Fantastic work by Katrina Davis in leading this 👏👏👏

dx.plos.org/10.1371/jour...

Did you know just how intertwined anxiety and depression can be? Studies show that >60% of people with anxiety also experience depression, and vice versa. This is called #comorbidity (1/4)