Susanne Brenzinger

This is figure 4, which shows collateral sensitivity and cross-resistance interactions between and within antibiotic classes.

Resistance to one antibiotic can make bacteria resistant or sensitive to another antibiotic, opening paths for combinatorial treatments. A study in Nature Microbiology presents an approach to systematically discover and understand such antibiotic relationships. https://go.nature.com/49of3Mk 🧪

Postdoctoral Position in Molecular Systems Biology

I have an open Postdoc position in Molecular Systems Biology at ETH Zürich!

The project is about the conservation of transcription factors functions between strains of Pseudomonas aeruginosa 🧬🦠

More details and application at:
jobs.ethz.ch/job/view/JOP...

Please share!

Credit: Daniela Velasco Lozano/EMBL

(1/3) Antibiotic resistance is costing human lives. 🦠
A study from EMBL's Typas group proposed a framework to identify antibiotic pairs that make bacteria resistant to one antibiotic but sensitive to other – this can help design new treatments and delay resistance. 🧬🧪

www.nature.com/articles/s41...

This is a very cute idea! If I may add one more: Klaus is probably one of our favorite Christmas movies ever.

a triangle 🔺

it’s a basic shape, but no bacteria is a triangle

a clothes hanger, a slice of pizza, a dorito—all triangles

just not bacteria

If there is one account worth following irrespective of your reasons for being on Bluesky, it is @auschwitzmemorial.bsky.social. A humbling and necessary constant reminder of the human abyss.

Trying to purify and sequence #phage for phage therapy?

Try #sphae a new approach to identify if your phage could be useful for treatment

#phagesky

EMBL Jobs We offer a wide range of challenging scientific and non-scientific positions at all of our European locations and encourage applications from international candidates at all career levels.

My first post on Blue Sky - moving over !

For all post-docs out there - fantastic opportunity @EMBL. Independent group leader position: Core funding, state-of-the-art core facilities, access to fantastic Ph.D. students, and of course amazing colleagues. Please apply www.embl.org/jobs/positio...

To fill up my empty feed, my first post on #bluesky.

Earlier this year we showed how the DdmDE system from pandemic Vibrio cholerae defends against invading plasmids. A great collaboration between the labs of Martin Jinek (UZH) and @mblokesch.bsky.social (EPFL).

www.science.org/doi/10.1126/...

Woohoo, the Microbiology Department (this includes me) at the JLU Giessen is looking for a new colleague (W2 with tenure track to W3).
Look here: uni-giessen.de/karriere/ste...
(and yes, knowledge of the German language is required ...).
Come to Giessen! We have cookies.

How do you analyze/visualize your data? You could use R & ggplot to make your graphs, no?

Thanks a lot Susanne! 😊

A new class of immune signaling molecules generated by TIR domains: histidine conjugated to ADP-ribose

Check out our preprint: tinyurl.com/hisADP

A fantastic collaboration with the Tamulaitiene and Kranzusch labs

In our case, we did not work towards phage theory but rather to better understand drug action. But the findings may have implications for future drug-phage co-treatment strategies.

The Vibrio cholerae CBASS phage defence system modulates resistance and killing by antifolate antibi... High-throughput growth assays show that cyclic-oligonucleotide-based anti-phage signalling systems modulate Vibrio cholerae sensitivity to antifolates, and ultimately trigger cell lysis by these drugs...

Can a phage defence system interfere with antibiotic action? 💊 Yes, it can! CBASS is triggered by antifolates and turns these mostly bacteriostatic drugs into bactericidal ones in bugs like V. cholerae. 🦠 www.nature.com/articles/s41564-023-01556-y Read full here: rdcu.be/du20r

Viruses wrap up bacterial defence systems Bacteria use diverse defences against viral predators called bacteriophages. A method to identify antibacterial counter-defences in viral genomes has revealed striking modes of defence inhibition. Pre...

Thank you Tim Blower and Stineke van Houte for an awesome news and views!🎁🎁 #phagesky

A never-ending defence fight - Nature Reviews Microbiology Two recent studies provide mechanistic understanding of how bacteria employ the Gabija system for defence against phages, as well as how phages use anti-defence proteins to overcome bacterial immunity...

Love this research highlight on our recent papers!🥊👊 @soreklab.bsky.social #phagesky

nature.com/articles/s41...

Scientists Pinpoint Cause of Severe Morning Sickness The discovery could lead to better treatments for severe nausea and vomiting during pregnancy.

Gift link to NYT article on an exciting breakthrough in treating extreme nausea in pregnant women (+ cancer patients). The female MD who conducted the breakthrough study (a) lost her pregnancy at 15 weeks gestation after suffering & (b) was told the problem was in her head.

Representation matters.

PIRATES!!
Constructing phagemids? Nature's been there before. A free rolling-circle plamid hijacks an Inovirus to hitch a ride. Fantastic observation and work by Nicole and great collaborators, made possible by @SPP2330. doi: doi.org/10.1101/2023.1

Broken Record Temperatures hit new highs, yet world fails to cut emissions (again) UN environment programme 。

this is a bloody great name for a climate report

www.unep.org/resources/em...

If I'm already on it, another tool I use when encountering a hypothetical uncharacterized protein is CDVist by the Zhulin lab. Great to predict domains and easy to use. Inviting rabbit holes included. 😅 cdvist.joulinelab.org

Ah the Dutch... cycling along their beautiful windmills eating poffertjes and bitterballen, washing it down with a liter of milk and not having a care in the world.

I started a #phage feed ... #phagesky

Add that hashtag to your posts to be included on the feed

One of the tools I find useful to get to know a new protein: PaperBLAST will find papers where your protein of interest has been described before. papers.genomics.lbl.gov/cgi-bin/litS...

The scientific, economical, and regulatory roadblocks to #phage therapy - the example of Germany
www.mdpi.com/1999-4915/15...

Phage researchers, could you help out?
Reviewer asks us to refer to "phage typing as a standard tool for the differentiation of Bacilli". Can anyone point to specific literature applicable to all Bacilli? Or is it only for differentiating certain species from each other?

Reversible conjugation of a CBASS nucleotide cyclase regulates immune response to phage infection https://www.biorxiv.org/content/10.1101/2023.09.29.560134v1 Antiviral defence systems build the prokaryotic immune system and their proper regulation is vital f

Reversible conjugation of a CBASS nucleotide cyclase regulates immune response to phage infection https://www.biorxiv.org/content/10.1101/2023.09.29.560134v1

The strain on scientific publishing 📄:

We've got issues. Scientists overwhelmed, editors overworked, constant special issue invites, mass article retractions, journal delistings… JUST WHAT IS GOING ON!?

See: arxiv.org/abs/2309.15884

A 🧵1/n
#AcademicChatter #PublishOrPerish #PhDAdvice #PhDChat

This is the outline of the SPP2330 meeting in Berlin.

I'm really looking forward to this meeting next week! It's been a great group of labs & projects and so many interesting presentations at the last meetings!

Can we limit infection by disarming pathogens rather than killing them? In this review we discuss the current state of play with this approach to tackle antibiotic resistance. www.nature.com/articles/s44...