Willi

One more now :)

Closet Genius: 🏗️ Building the Foundation, why I chose AWS CDK (and you might too) Why I chose AWS CDK for my AI wardrobe app: building production-ready infrastructure with TypeScript instead of clicking buttons in the AWS console.

"Closet Genius: 🏗️ Building the Foundation, why I chose AWS CDK (and you might too)" by Nelly

#kiro #kiro-agent

Belgian AI scientists resist the use of AI in academia Several AI scientists have published an open letter calling for a ban on AI use by students.

Belgian AI scientists resist the use of AI in academia

🙏 👏

#ESR #academicsky

apache.be/2025/10/24/b...

Largest study of its kind shows AI assistants misrepresent news content 45% of the time – regardless of language or territory An intensive international study was coordinated by the European Broadcasting Union (EBU) and led by the BBC

Largest study of its kind shows AI assistants misrepresent news content 45% of the time – regardless of language or territory. www.bbc.co.uk/mediacentre/...

Comment: Why flavor chemistry is the perfect gateway for outreach to all ages Chemical & Engineering News (C&EN): Keeping you up to date with the chemistry news that matters most. Published by the American Chemical Society.

"Chemistry becomes meaningful when it’s rooted in relevance, when someone sees it, tastes it, and feels it. And what better gateway than spices?"

#NationalChemistryWeek #ACS_NCW #SpiceChemistry cen.acs.org/acs-news/com...

We train machine learning models on millions of proteins. But when it comes to making predictions, do we need them to understand all proteins at once? Often, we need an accurate model for the specific protein we are studying or designing. We address this with ProteinTTT arxiv.org/abs/2411.02109 1/🧵

Google AI aims to make best-in-class scientific software even better An artificial-intelligence-guided software-evolution system tweaks tools to boost performance.

Google has unveiled an AI workflow that evolves scientific software using a large language model to "mutate" code. In several domains, the resulting programs outperformed state-of-the-art tools, reducing development time from months to days.

Aromatic cation−π-dominated pathway control in living supramolecular polymerization - Nature Synthesis Living supramolecular polymerization (LSP) is a promising strategy to construct well-defined supramolecular nanostructures but precise control over polymerization remains challenging. Here, a cation−π...

Now online:

Article by Wei Tian & co-workers

Aromatic cation−π-dominated pathway control in living supramolecular polymerization

www.nature.com/articles/s44... ($)
#Chemsky

A porous molecularly woven fabric for dynamic separation of water isotopologues - Nature Synthesis The low natural abundance of heavy water makes high-purity extraction challenging. Here, a porous molecularly woven fabric is constructed that features adaptive pores enabling the efficient dynamic se...

Now online and open access:

Article by Ming Liu, Guangfeng Li, Feihe Huang & co-workers

A porous molecularly woven fabric for dynamic separation of water isotopologues

www.nature.com/articles/s44...
#Chemsky

Is Sora the Beginning of the End for OpenAI? - Cal Newport On ​my podcast this week​, I took a closer look at OpenAI’s new video generation model, ​Sora 2​, which can turn simple text descriptions into ... Read more

"To me, these are the acts of a company that poured tens of billions of investment dollars into creating what they hoped would be the most consequential invention in modern history, only to finally realize that what they wrought (...) isn’t powerful enough"
calnewport.com/is-sora-the-...

Thesis | An Exploration of Artificial Intelligence-Driven De Novo Peptide Sequencing: Towards Future Proteomics and Medicine researchprofiles.ku....

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#proteomics #prot-other

A chiral mesostructured photocatalyst for efficient solar-driven CO2 reduction to ethanol - Nature Synthesis A chiral mesostructured copper-doped In2S3 photocatalyst is reported for photocatalytic CO2 reduction to ethanol. Chirality-induced spin polarization stabilizes key intermediates, which are converted ...

Now online:

Article by Yanhang Ma, Renzhong Tai, Jinquan Chen, Changlin Tian, Shunai Che, Yuxi Fang & co-workers

A chiral mesostructured photocatalyst for efficient solar-driven CO2 reduction to ethanol

www.nature.com/articles/s44... ($)
#Chemsky

AI discovers learning algorithm that outperforms those designed by humans An artificial-intelligence algorithm that discovers its own way to learn achieves state-of-the-art performance, including on some tasks it had never encountered before.

An AI algorithm that discovers its own way to learn achieves state-of-the-art performance, including on some tasks it had never encountered before

go.nature.com/3L4AmKL

Living dangerously with Claude I gave a talk last night at Claude Code Anonymous in San Francisco, the unofficial meetup for coding agent enthusiasts. I decided to talk about a dichotomy I’ve been struggling …

I gave a talk last night about "Living dangerously with Claude", on the joys and perils of --dangerously-skip-permissions and how critical it is that we run coding agents in a sandbox so that we can unlock their full potential simonwillison.net/2025/Oct/22/...

Largest study of its kind shows AI assistants misrepresent news content 45% of the time – regardless of language or territory An intensive international study was coordinated by the European Broadcasting Union (EBU) and led by the BBC

45% of all AI answers had at least one significant issue.
31% of responses showed serious sourcing problems – missing, misleading, or incorrect attributions.
20% contained major accuracy issues, including hallucinated details and outdated information.

www.bbc.co.uk/mediacentre/...

SmallBARNA 2026: a kingdom-wide bacterial sRNA resource Abstract. Bacterial small RNA are important context-sensitive regulators of gene expression, especially in highly pathogenic bacteria, often controlling vi

academic.oup.com/nar/advance-...

#microsky a database of bacterial small RNA experimental data

A Web Component for Conditionally Displaying Fields :: Aaron Gustafson Building on my recent work in the form utility space, I’ve created a new web component that allows you to conditionally display form fields based on the values of other fields: form-show-if.

Sometimes you only want a field to show when certain other fields have a (particular) value. The `form-show-if` web component enables that.

Phage quest: a beginner’s guide to explore viral diversity in the prokaryotic world Abstract. The increasing interest in finding new viruses within (meta)genomic datasets has fueled the development of computational tools for virus detectio

Interesting paper on bacteriophage genomics and bioinformatics

'Phage quest: a beginner’s guide to explore viral diversity in the prokaryotic world' by @sebwielgoss.bsky.social and colleagues

academic.oup.com/bib/article/...

Please turn off the TV immediately!

"The notion that generative AI means the end of professional programming is not only misguided—it is dangerous."
Mira Mezini
archive.ph/i46O3#select...

More and more, I'm seeing AI-generated (or "enhanced") headshots everywhere from LinkedIn to dating sites. To me, at least, that is an immediate no. Relationships, be they employment or personal, are built on trust. An AI-genereated (or even "enhanced") photo is a lie, plain and simple.
1/2

A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity A prokaryotic RNA–directed targeting system can be designed to cleave any DNA sequence.

13 years ago, the revolutionary genetic tool #CRISPR/Cas9 was published in Science, work that Emmanuelle Charpentier and Jennifer Doudna won a #NobelPrize for in 2020.

On #WorldCRISPRDay, read the landmark paper that describes the discovery: https://scim.ag/42JHuSN

Gita Gopinath on the crash that could torch $35trn of wealth The world has become dangerously dependent on American stocks, writes the former IMF chief economist

Gita Gopinath, former IMF chief economist, on the AI bubble: "A market correction of the same magnitude as the dotcom crash could wipe out over $20trn in wealth for American households, equivalent to roughly 70% of American GDP in 2024."

This Is How Much Anthropic and Cursor Spend On Amazon Web Services So, I originally planned for this to be on my premium newsletter, but decided it was better to publish on my free one so that you could all enjoy it. If you liked it, please consider subscribing to su...

Exclusive: Anthropic spent $2.66 billion on Amazon Web Services in the first three quarters of 2025, around 100% of their estimated revenue. Its costs appear to increase with their revenue, showing little path to profitability.
www.wheresyoured.at/costs/

We (@sobuelow.bsky.social) developed AF-CALVADOS to integrate AlphaFold and CALVADOS to simulate flexible multidomain proteins at scale

See preprint for:
— Ensembles of >12000 full-length human proteins
— Analysis of IDRs in >1500 TFs

📜 doi.org/10.1101/2025...
💾 github.com/KULL-Centre/...

Why simply ending animal testing isn’t the answer in biomedical research Animal models provide insights that alternative approaches can’t. A heated debate about which method is better is distracting researchers from doing good science.

Animal models provide insights that alternative approaches can’t, says K. C. Kent Lloyd

go.nature.com/43ikOJy

John Gurdon obituary: Biologist who made cloning possible He showed that specialized cells retain the genes to form an organism.

Obituary: John Gurdon (1933-2025) Biologist who made cloning possible

go.nature.com/3WicRAe

GOOD NEWS! For the first time ever, Huntington's disease has been successfully treated. A groundbreaking new miRNA treatment, AMT-130, slowed the progression of the disease by 75%. These results are likely to support the first approval of a genetic treatment for the rare neurodegenerative condition.

A new 246-pages book on MCMC.

"Finite Markov chains and Monte-Carlo Methods: An Undergraduate Introduction"

This is a free textbook suitable for a one-semester course on Markov chains, covering basics of finite-state chains, many classical models, asymptotic behavior and mixing times,

An Opinionated Guide to Using AI Right Now What AI to use in late 2025

I wrote an updated guide on which AIs to use right now, & some tips on how to use them (and how to avoid falling into some common traps)

A lot has changed since I last wrote a guide like this in the spring, and AI has gotten much more useful as a result. open.substack.com/pub/oneusefu...