Francesca Ciccarelli

Midsummer night 🌟🌙

Induction of a mismatch repair deficient genotype by tailored chemical mutagenesis in experimental models of cancer Mismatch repair deficient (MMRd) tumors harbor thousands of somatic mutations enriched for insertion–deletion (indels) conferring high sensitivity to …

This is an important milestone: mutagenic drugs can increase TMB and induce a dMMR-like genetic profile, but do not improve response to immunotherapy in pMMR CRC patients. Some evidence of TIME remodelling, but likely not in the direction needed fro response... www.sciencedirect.com/science/arti...

Great meeting and great questions! Thanks for inviting me!

Our very own @mirjana-efremova.bsky.social (very small compared to the very huge screen) speaking about her beautiful data on cell plasticity in cancer mets at the #Beatson International Cancer Conference. @qmbci.bsky.social @cruk-mi.bsky.social

La Caixa panel dinners are always a treat! View of Barcelona from the museum of Catalan art

I spent two days meeting students and faculty & delivering the keynote speech at the London Health Research Day @westernu.bsky.social. I truly enjoyed the enthusiasm and genuine engagements of the young generation of cancer researchers! Thanks @ggloor.bsky.social & colleagues for inviting me!

Street crossing in London, ON 🦆🦆🦆

Gorgeous day in NYC

Thanks for inviting. It was fun!

Familiar faces in Belfast! Enjoyable time at the meeting of the Irish Association for Cancer Research! @qmbci.bsky.social

Next Thu 13th March Ilaria Malanchi @ila07.bsky.social and I will host the next "Medicine at the Crick" event focusing on how tissues evolve over time and why this may initiate disease. Free in person/virtual registration @crick.ac.uk: www.eventbrite.co.uk/e/medicine-a...

Dear Volodymyr Zelenskyy, dear Ukrainian friends, you are not alone.

We have two open positions for #computationalbiologists to work on:
1. Early cancer initiation following our work in #NatureCancer (Ref 5028)
2. Response to cancer immunotherapy following our work in #CancerCell (Ref 5073)
To apply use the provided reference numbers: www.qmul.ac.uk/jobs/vacanci...

Beautiful cover 😍 from an idea of our own @pedrandrei.bsky.social! Credits to Joe Brock from @crick.ac.uk

Very timely publication on World Cancer Day and spot on title considering the times we live in. I am very proud of all wonderful colleagues that dedicate their talent to understand, treat and eventually cure cancer @qmbci.bsky.social 💪💪💪

Really enjoyed @mirjana-efremova.bsky.social talk on phenotypic plasticity in #ColorectalCancer

Super clear explanation of role of key genes ( #LRIG1 etc) in cell switch

@qmbci.bsky.social
@ciccarellilab.bsky.social
@drtanyasoliman.bsky.social
@mcclellandlab.bsky.social
@sibucz.bsky.social

Cool to be at #FoG2025 @fogenomics.bsky.social

A bit more #SpatialGenomics content this year which is great!

Surprise visit from #Darth & #Chewbacca!

@ciccarellilab.bsky.social @mirjana-efremova.bsky.social
@karlsmithbyrne.bsky.social
@qmbci.bsky.social
@omaiques.bsky.social

Wait for me!! 😊

Great talk from Hrvoje Misetic on the context dependent role of Cdkn2a in cancer evolution @qmbci.bsky.social @cruk-cityoflondon.bsk.social. Well done 👏💪👌

Nathaniel MonPere from @benjaminwerner.bsky.social lab in the Centre for Cancer Evolution @qmbci.bsky.social modelling #clonalhaematopoiesis in ageig at the Annual Symposium of @cruk-cityoflondon.bsky.social

With Ilaria Malanchi @ila07.bsky.social we will host the #MedicineattheCrick event (13th March at the Crick @crick.ac.uk.) Join world experts to discuss how early mutant cells interact with surrounding niche to maintain homeostasis or start cancer. Free registration! Details in the poster 👇

Strong Barts representation at the Cancer Research Nottingham Annual Symposium! @francesbalkwill.bsky.social @qmbci.bsky.social @uniofnottingham.bsky.social

Hi all, our lab will soon recruit a PhD student working within a very exciting MSCA Horizon Doctoral network working on ageing, UNION, which gathers some fantastic scientists. Please apply if your profile fits our project (see attached advert).
Looking forward to working with you!

🔥🔥🔥

Thanks Felipe! ❤️

😘

Thanks to @ameachasag.bsky.social @pedrandrei.bsky.social @emmataggart.bsky.social @barrallab.bsky.social and all other coauthors not (yet) in bsky! Thanks to @crick.ac.uk and @qmbci.bsky.social @cancerresearchuk.org @cruk-cityoflondon.bsky.social and all other funding agencies that support us!

A constitutive interferon-high immunophenotype defines response to immunotherapy in colorectal cancer Fewer than 50% of metastatic deficient mismatch repair (dMMR) colorectal cancer (CRC) patients respond to immune checkpoint inhibition (ICI). Identify…

New paper from our lab just out in @cp-cancercell.bsky.social! Integrating spatial omics, cell co-cultures and staining of clinical trial samples, we show that CD74 marks the right local microenvironment for #immunotherapy response. Excitingly, this may increase the number of treatable patients!

Sunrise in Islington

Effects of CDKN2A loss on evolution of esophageal adenocarcinoma depend on context and time - Nature Cancer Loss of CDKN2A is known to drive the progression of several cancers, including esophageal adenocarcinoma (EAC). Genetic analyses of samples of Barrett’s esophagus (EAC precursor condition) show that e...

Nature Research Briefing asked us to explain our recent discovery (rdcu.be/d5pty) to a wider readership. The piece includes a comment from an external expert (thanks #StephenMeltzer, at #JohnHopkins!) and some "behind the paper" curiosities... www.nature.com/articles/s43...