GLIORESOLVE

We are committed to tackling GBM through innovative research and collaboration. On #WorldCancerResearchDay, we celebrate the dedication of scientists and clinicians working to understand cancer, develop new therapies and improve patient outcomes. Together we push the boundaries of #cancerresearch

🧠 New study from MIMETAS & Roche (pRED) shows how the ApoE4 Alzheimer’s risk gene alters brain endothelial function & iron transport.

Using our iPSC-based BBB model + Roche’s BrainShuttle tech, we uncovered ApoE4-driven changes that may shape how therapies can reach the brain. shorturl.at/RwgUP

YouTube video by KSAT 12 The Conversation: Mays Cancer Center recruiting glioblastoma patients for trial

A new clinical trial is recruiting patients with glioblastoma — the most aggressive brain tumor in adults. KSAT’s The Conversation talks to Dr. Andrew Brenner about the study and how patients can get involved. #Glioblastoma #ClinicalTrial #BrainCancerResearch
youtu.be/5Vm95A-zVcE?...

📣 Join us in #Prague on 15 Oct for the GLIORESOLVE #EANO2025 satellite pre-meeting! Speakers: Prof Patrick Wen (Harvard), Prof Anna Dimberg (Uppsala), Prof Gabriele Bergers (VIB), Dr Kate Connor (TCD) plus research highlights from our PhD students. Details & registration: www.eano.eu/eano2025/pro...

Level up your science! Explore EMBL’s hands-on courses, conferences, and learn cutting-edge techniques from world-class experts. Here is the poster for 2026 #EMBL #EMBLEvents #LifelongLearning #ScienceTraining

AI Augmented Biology Organised by Nanjing University，Nature, Nature Communications, Nature Biotechnology, Nature Methods The Nature conference on "AI Augmented Biology" explores how the integration of artificial intellige...

Nanjing University is organizing "AI Augmented Biology," a conference in China on AI's integration with biological sciences. Topics include multi-modal data, protein engineering, and LLMs for biology.
🗓️ Oct 22-24, 2025
📍 Nanjing, China

#AIinScience #Bioinformatics #Genomics #Conference

AlphaGenome: AI for better understanding the genome Introducing a new, unifying DNA sequence model that advances regulatory variant-effect prediction and promises to shed new light on genome function — now available via API.

Google has introduced AlphaGenome, an AI model designed to predict the impact of genetic mutations on gene regulation across the human genome. This development aims to contribute to the understanding of disease mechanisms and potential therapeutic avenues. #AlphaGenome #AI #Genomics

Here are some links that may be of use if you or your family members are facing a glioblastoma diagnosis theibta.org
braintumourireland.com
stophersentumoren.nl
brainstrust.org.uk
www.thebraintumourcharity.org
artc-asso.fr www.thebraintumourcharity.org/living-with-...

GLIORESOLVE

On #GlioblastomaAwarenessDay, we reflect on lives affected by this devastating disease. In #GLIORESOLVE, we’re working to understand the complex landscape that surrounds and fuels each tumour — aiming for more personalised, effective treatments #BrainTumourResearch www.glioresolve.eu

More than 13,000 Americans will be diagnosed with #glioblastoma in 2025, yet treatments and survival rates have remained largely unchanged for decades.

📣 This #GBMDay, reshare these stats to raise public awareness and inspire action.

Learn more: braintumor.org/events/gliob...

We can't wait👏 We are especially looking forward to hosting an #EANO2025 satellite pre-meeting on the 15 October. Talks from Prof Patrick Wen, Prof Anna Dimberg, Prof Gabriele Bergers and Dr Kate Connor + research highlights from our students. Details & FREE registration👉 www.eano.eu/eano2025/pro...

📣 Join us in #Prague on 15 Oct for the GLIORESOLVE #EANO2025 satellite pre-meeting! Speakers: Prof Patrick Wen (Harvard), Prof Anna Dimberg (Uppsala), Prof Gabriele Bergers (VIB), Dr Kate Connor (TCD) plus research highlights from our PhD students. Details & registration: www.eano.eu/eano2025/pro...

Join ICSB2025 in Dublin: The late-breaking abstract deadline has been extended to August 1st (for oral presentation) and September 1st (for posters). Hope to see you in Dublin! icsb2025.com

Happy to share our latest work by Verheul, Fabro etal, describing our optimized protocol for establishing GBM cell cultures. Another step forward to personalized drugscreening for GBM patients! Thank you to everyone who contributed.🙏𝗡𝗮𝘁𝘂𝗿𝗲 𝗣𝗿𝗲𝗰𝗶𝘀𝗶𝗼𝗻 𝗢𝗻𝗰𝗼𝗹𝗼𝗴𝘆(2025)
🔗 www.nature.com/articles/s41...

The multilayered transcriptional architecture of glioblastoma ecosystems - Nature Genetics Integrated single-cell transcriptomic and genetic characterization of 121 adult glioblastomas identifies heterogeneity at cell type, cell state and baseline expression program levels associated with s...

This recent study maps the transcriptional heterogeneity of IDH-wildtype glioblastoma, identifying distinct cellular states and gene programs across disease stages:
"The multilayered transcriptional architecture of glioblastoma ecosystems"
doi.org/10.1038/s415...

Deciphering the longitudinal trajectories of glioblastoma ecosystems by integrative single-cell genomics - Nature Genetics Comparison of paired primary and recurrent glioblastomas at the single-cell transcriptomic level describes molecular and cellular trajectories associated with tumor recurrence, highlighting extensive ...

It has long been known that glioblastoma(GBM) tumor microenvironment evolves; how therapy shapes the GBM TME remains poorly understood. This recent article sheds light on it: "Deciphering the longitudinal trajectories of GBM ecosystems by integrative single-cell genomics" doi.org/10.1038/s415...

📣 **SAVE THE DATE** The GLIORESOLVE consortium is hosting a satellite conference at #EANO2025 in Prague on 15 October. We have an outstanding lineup of invited speakers and exciting research updates from the network. Free registration will open soon via the EANO website. #BrainTumourResearch

A man and woman pose in yellow and green ceremonial robes. The woman is wearing a black silk blouse, has brown hair and a fringe and is holding a scroll and shaking the hand of the man who is wearing a navy suit and blue tie.

Professor Annette Byrne, Professor of Physiology at RCSI and head of the RCSI Precision Cancer Medicine Group has been elected as a Member of the Royal Irish Academy, Ireland’s foremost body of experts in sciences and humanities.

🔗 tinyurl.com/4yx2auwx

#RCSIdiscover

Huge congratulations to Prof Byrne 👏🏻👏🏻

Professor Annette Byrne elected as Member of the Royal Irish Academy Professor Annette Byrne has been elected as a Member of the Royal Irish Academy (MRIA), Ireland’s foremost body of experts in the sciences and humanities. More ...

Congratulations again to GLIORESOLVE Coordinator Prof Annette Byrne who has been elected as a Member of the Royal Irish Academy. Read the RCSI press release here www.rcsi.com/dublin/news-... @physiologyrcsi.bsky.social @mariescurie-ire.bsky.social @horizoneu.bsky.social @researchireland.ie

De novo design of porphyrin-containing proteins as efficient and stereoselective catalysts De novo design of protein catalysts with high efficiency and stereoselectivity provides an attractive approach toward the design of environmentally benign catalysts. Here, we design proteins that inco...

Impressive de novo enzyme design! 🧪 Researchers engineered new protein catalysts for cyclopropanation (some >99:1 e.r.!) & Si-H insertion. They even used directed evolution in whole cells to optimize! Shows efficient catalysts are designable. #ProteinDesign
www.science.org/doi/10.1126/...

Design principles of cell-state-specific enhancers in hematopoiesis Screen of minimalistic enhancers in blood progenitor cells demonstrates widespread dual activator-repressor function of transcription factors (TFs) and enables the model-guided design of cell-state-sp...

How do enhancers drive cell specificity? 🤔 Fascinating study used 64k+ synthetic sequences in blood cell differentiation & found activating TF sites often show negative synergy, converting TF gradients into sharp gene patterns! #Bioinformatics
www.cell.com/cell/fulltex...

An AI Agent for Fully Automated Multi‐Omic Analyses This study introduces AutoBA, which is an AI agent designed for fully automated multi-omic analyses based large language models. AutoBA simplifies bioinformatics tasks with minimal user input, offeri...

Meet AutoBA: An autonomous AI agent simplifying complex multi-omic analysis! 🧬 Features LLM power, self-designing plans, online/local flexibility, Auto Code Repair, & adaptability to new tools. #bioinformatics #AI #genomics #LLM #AutoBA
advanced.onlinelibrary.wiley.com/doi/full/10....

Deciphering the longitudinal trajectories of glioblastoma ecosystems by integrative single-cell genomics - Nature Genetics Comparison of paired primary and recurrent glioblastomas at the single-cell transcriptomic level describes molecular and cellular trajectories associated with tumor recurrence, highlighting extensive ...

1/ Truly excited to share our new study that I had to privilege to co-lead during my PhD alongside great friends and collaborators @masashi-nomura.bsky.social, @kevin-johnson.bsky.social and Luciano Garofano, published at Nature Genetics @natureportfolio.nature.com!

www.nature.com/articles/s41...

YouTube video by UniHeidelberg SFB 1389: Überwindung der Therapieresistenz von Glioblastomen.

UNDERSTANDING AND TARGETING RESISTANCE in Glioblastoma (UNITE Glioblastoma) ist eine DFG geförderte Forschungsinitiative, Hier ein Interview mit Prof. Wolfgang Wick @wickwolfgang.bsky.social und Dr. Sophie Heuer im Rahmen der Reihe ÜBERLEBENSSTRATEGIEN: www.youtube.com/watch?v=BO3I...

Great paper focusing on the secondary use of health data in Ireland, exploring issues surrounding use of health data for purposes beyond patient care @rcsipophealth.bsky.social #healthdata #secondaryuse #scientificresearch

This recent paper explores how the ketogenic diet might have potential benefits on the progression of GBM patients. Check it here: doi: 10.3389/fnut.2024.1489812
#GBM #Glioresolve

Vaccine-induced T cell receptor T cell therapy targeting a glioblastoma stemness antigen - Nature Communications Vaccination in glioblastomas does lead to the emergence of tumour-antigen-specific T cells but T cell dysfunction, poor tumour infiltration and persistence hinder efficient tumour killing. Here author...

🚀 New publication! We developed a PTPRZ1-specific TCR-T cell therapy for glioblastoma.

🔬 Key findings:
✅ Identified a PTPRZ1-reactive TCR from a vaccinated patient
✅ Kills glioblastoma cells with no off-target effects
✅ Eliminates tumors in murine brain models

🔗 www.nature.com/articles/s41...

Brain Tumour Magazine: World Edition 2024/2025 The fourteenth annual edition of the official magazine of the International Brain Tumour Alliance (IBTA).

The GLIORESOLVE project was featured in the 2024/2025 World Edition of the Brain Tumour Magazine, published by the @theibta.bsky.social You can read the full publication here issuu.com/ibta-org/doc... and our article is on Pg 23!

Programs, origins and immunomodulatory functions of myeloid cells in glioma - Nature A study of myeloid cells in gliomas, a type of brain tumour, used a factor-based computational framework to reveal four immunomodulatory gene-expression programs that are expressed across myeloid cell...

A new study from Nature suggests four novel gene expression programs in glioma-associated myeloid cells (💡): www.nature.com/articles/s41...