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Costanza Lo Cascio

@costanzalc.bsky.social

Damon Runyon-St. Jude Fellow @DanaFarber.bsky.social @HarvardMed.bsky.social | Filbin Lab | Pediatric Neuro-Oncology | Runner | Tetris enthusiast.

365 Followers  |  505 Following  |  1 Posts  |  Joined: 18.11.2024  |  1.4164

Latest posts by costanzalc.bsky.social on Bluesky

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Effective targeting of PDGFRA-altered high-grade glioma with avapritinib PDGFRA is commonly altered in pediatric HGG. Mayr etย al. report that the PDGFRA/KIT inhibitor avapritinib demonstrates on-target activity, brain penetrance, and survival benefit in pre-clinical H3K27M...

Thrilled to share our work with Mariella Filbin, Johannes Gojo and Carl Koschmann, now published in @cp-cancercell.bsky.social We present a translational approach identifying the PDGFRA inhibitor avapritinib as a novel targeted treatment for pHGG with PDGFRA alterations www.cell.com/cancer-cell/...

13.03.2025 15:30 โ€” ๐Ÿ‘ 8    ๐Ÿ” 2    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0
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Safeguarding the future of biomedical science in the United States NIHโ€™s abrupt decision to cap indirect cost reimbursement at 15% threatens the critical infrastructure supporting groundbreaking biomedical research in the United States. This policy jeopardizes Americaโ€™s global leadership in science and medicine. Urgentโ€ฆ

Now online! Safeguarding the future of biomedical science in the United States

01.03.2025 13:42 โ€” ๐Ÿ‘ 12    ๐Ÿ” 12    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0
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Mapping the developmental trajectory of human astrocytes reveals divergence in glioblastoma Nature Cell Biology - Sojka et al. analyse the transcriptomic and epigenomic landscape of human astrocyte maturation and identify an epigenetically regulated intermediate state associated with...

First ๐Ÿฆ‹ post! Very excited to share our lab's latest work exploring the shared and divergent aspects of human astrocyte development and glioblastoma. This effort spans many fields from developmental #glial biology to #stem cells and #tumor biology. rdcu.be/d5ADz A ๐Ÿงต

08.01.2025 17:13 โ€” ๐Ÿ‘ 132    ๐Ÿ” 40    ๐Ÿ’ฌ 3    ๐Ÿ“Œ 8

Would love to be added as well. Thank you!

19.11.2024 13:40 โ€” ๐Ÿ‘ 1    ๐Ÿ” 0    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0

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