Michele Stasi

Active transport enables protein condensation in cells The force generated by active transport modulates protein condensation.

Biomolecular condensates are critical for organizing cellular contents, but most studies focus on phase separation driven by salt, pH, or temperature.
But what if intracellular movement also matters?
Here, we explore motility-induced condensation in the cell.
www.science.org/doi/10.1126/...

Genome-wide mapping of mesoscale neuronal RNA organization and condensation Subcellular RNA organization can affect critical cellular functions. However, our understanding of RNA microenvironments, particularly biomolecular condensates, remains limited, largely due to a lack ...

What drives cytoplasmic mRNA organization? We created unbiased, genome-wide maps of mesoscale RNA-RNA spatial proximity, revealing impact of encoded protein function. Fantastic work from @lindsayabecker.bsky.social @sofiquinodoz.bsky.social @davidaknowles.bsky.social www.biorxiv.org/content/10.1...

@science.org Cryo-EM reveals mechanisms of natural RNA multivalency | Science www.science.org/doi/10.1126/...
#RNAsky #RNAbiology #Cryo-EM

“Mundus sine Caesaribus”

I believe that science is a collective endevour: we stands on the shoulders of giants. If i got here is thanks to the support of my supervisor @diantoniogroup.bsky.social and PhD advisor @boekhovenlab.bsky.social, as well as the continous exchange of ideas with collegues and friends :)

I'm over the moon to share that i've been awarded a Marie Sklodowska-Curie Fellowship to investigate nucleic acid folding coupled to phase separation in the Di Antonio Lab at Imperial.

Mysterious Blobs in Cells Are Changing the Way We Understand Life Tiny specks called biomolecular condensates are leading to a new understanding of the cell

In the cover story of the February issue of @sciam.bsky.social I explain what biomolecular condensates are and why they are transforming cell biology. A short 🧵
(You'll need a subscription to read the article.)
www.scientificamerican.com/article/myst...

Gene-scale in vitro reconstitution reveals histone acetylation directly controls chromatin architecture

Yet more evidence transcription factors are nothing more than glorified Uber drivers for acetyltransferase activity:

www.biorxiv.org/content/10.1...

Research involves day science and night science, requiring you to become good at both. Day science proceeds in logical steps and specializes in hypothesis testing, but to generate new ideas we pop out to the creative night science world, where leaps among ideas are made possible.

Quantitative Spatial Analysis of Chromatin Biomolecular Condensates using Cryo-Electron Tomography Phase separation is an important mechanism to generate certain biomolecular condensates and organize the cell interior. Condensate formation and function remain incompletely understood due to difficul...

🤩🤩

www.biorxiv.org/content/10.1...

Bluesky is emerging as the new platform for science - Mike Young Academy Scientific Twitter is about to find its true successor. And it is not X. This, our latest release, shows that the Bluesky network of scientists is growing — and growing.

🌍 We have just released a NEW global top 100 list of scientist and science communicators on Bluesky. @lassehjorthmadsen.bsky.social and I map out the new emerging community: How are the research fields clustered? All likes, reshares, and love 😍 is appreciated! mikeyoungacademy.dk/bluesky-is-e...

Like ‘old Twitter’: The scientific community finds a new home on Bluesky After recent changes to Elon Musk’s X, a gradual migration turns into a stampede

www.science.org/content/arti...

Yeeees! Now, it's only missing a share function on websites!

A figure points at a bookshelf in the shape of a Christmas tree which is decorated with lights and has a star on top and says: "It combines the festive jollity of a regular Christmas tree with the clear message that I'd like every one of my gifts to be a book."

A Christmas cartoon for the Guardian. Happy holidays, everyone!

Reaching 1 Million Users Today, we reached over one million users on Bluesky.

We reached 1,000,000 users!

blueskyweb.xyz/blog/9-12-20...

Found a new home in Bluesky :)
#eXit #Bluesky