Nick Riley

Antibody-lectin chimeras for glyco-immune checkpoint blockade - Nature Biotechnology Cancer immunotherapy benefits from antibody-lectin chimeras that block glyco-immune checkpoints.

Antibody-lectin chimeras for glyco-immune checkpoint blockade - @jcstark.bsky.social @carolynbertozzi.bskyverified.social go.nature.com/4aRDpk8

You would be surprised at how often this confusion was happening even in the ~2015 era. It was a consistent chorus of “no, not that AI”.

A new jump forward in cancer immunotherapy blocking glycan sugar molecules (antibodies to lectin, AbLec) that releases the immune system brakes against many types of tumors @carolynbertozzi.bskyverified.social @jcstark.bsky.social www.nature.com/articles/s41...

It was a great meeting at OHSU, and it’s always fun to connect with @carolynbertozzi.bskyverified.social alum!

Had a blast at the OHSU Chemical Biology & Physiology meeting this week! Amazing talks, great to see lab alum Brittany White-Mathieu’s developing program at UNH, reconnect with friends and collaborators, meet some of the next generation of #chembio, and explore Portland!

Discovering Glycosylation-Dependent Protein Function by Thermal Proteome Profiling Protein glycosylation regulates essential cellular processes including protein folding, stability, and cell-cell interactions; however, how aberrant glycosylation impacts protein function and interact...

Congratulations former postdoc @jfhevler.bsky.social (in transit to Roche) and the team on their work using thermal proteome profiling along with glycosylation perturbagens to discover glycan-dependent protein functions at the proteome scale 👏

www.biorxiv.org/content/10.6...

Awards for Undergraduate Students Visit the post for more.

Do you know outstanding undergraduate researchers who could use up to $1,000 in travel funding to present their work at the Spring @acs.org or @pittcon.bsky.social Meetings?

Please encourage them to apply for a Kolthoff award! Deadline is Jan. 12, 2026.

acsanalytical.org/undergraduat...

Commercial O-glycoprotease options include OgpA (brand name OpeRATOR from Genovis), IMPa (from NEB), and StcE (from Sigma).

They all have pros and cons. We use IMPa the most of any of them and are pretty happy with it.

Unfortunately, no. One of the big challenges of O-glyco. There are cocktails of glycosidases that can work in concert (see DeGlycoMixII from NEB), but they are inefficient and don’t leave a mass signature. O-glycoproteases can cleave the peptide backbone at O-glycosites. But no PNGaseF equivalent.

And of course thanks to all co-authors and hopefully reaching out to future users @gundrylab.bsky.social @nmriley.bsky.social @khookh.bsky.social @cashwood.proteaglyco.com @wandalllab.bsky.social @glyconet.bsky.social and so many I cannot include...

Awards for Undergraduate Students Visit the post for more.

Do you know outstanding undergraduate researchers who could use up to $1,000 in travel funding to present their work at the Spring @acs.org or @pittcon.bsky.social Meetings?

Please encourage them to apply for a Kolthoff award! Deadline is Jan. 12, 2026.

acsanalytical.org/undergraduat...

Who Inspires you? In the annual Talented 12 program, C&EN highlights extraordinary early-career chemists shaping the future of chemistry.

Know an inspiring early-career chemist? Nominate an early-career chemist for the 2026 Talented 12 at cen.acs.org/sections/tal...

Submit your nomination by January 20, 2026.

#CENT12 #MassSpec #Chemistry

Have you compared it to Inkscape? Any reasons why you may like Affinity better? We’ve been using Inkscape, so it would be a big lift to switch. I’m curious if Affinity offers things that may make it worth considering, though!

This subject came up in the Nobel Minds broadcast (2022) during the conversation at 25:50, note economics Laureate Ben Bernanke’s “puzzlement” as to Why, and the audience’s response to the entire exchange.

youtu.be/LutI8YqJkqM?...

Uche Medoh

For solving a 50-year mystery by uncovering the machinery behind BMP, a molecule with protective effects against various disorders, Uche Medoh is the winner of the 2025 Science & SciLifeLab Prize for Young Scientists.

🎉 Learn more about the work: https://scim.ag/4qVpK1a

An ultrasensitive and modular platform to detect Siglec ligands and control immune cell function Siglec-liposomes are a multivalent and modular platform for profiling Siglec ligands and modulating immune cell function.

Excited to share our laboratory's research tools to study Siglecs along with some interesting discoveries with these tools. Lot of help from many group, but @zeinab-jc.bsky.social was the major driver of this work. Please reach out if you would like to try them out. www.science.org/doi/10.1126/...

US HUPO - Computational Proteomics Award

Congratulations to Bill Noble on receiving the 2026 Gil Omenn Computational Proteomics Award from US HUPO!
us-hupo.org/Computationa...

US HUPO - Distinguished Contribution Award

Congratulations to Mike MacCoss on receiving the Donald F. Hunt Distinguished Contribution in Proteomics Award from US HUPO!
us-hupo.org/Distinguishe...

Have fun with the poster presentation today @timveth.bsky.social!

The overlap of #HUPO2025 with #SFG2025 this week means I’m missing out on the #glycotime fun at SFG in San Diego.

I am happy postdoc @timveth.bsky.social is able to represent @riley-research.bsky.social at SFG instead!

@timveth.bsky.social is not only attending #SFG2025 - he helped organize Glycopalooza events for early career researchers and is presenting poster B10-110 Tuesday. Check it out in session 2 to hear his impressive work integrating bottom-up and top-down methods to define glycoproteoform heterogeneity

Not only did Kayla do a great job with her #HUPO2025 presentation, but she also was recognized this afternoon as one of the winners of the competitive 2025 Quantitative Proteomics Grant from Thermo Fisher Scientific.

Way to go, Kayla!

@timveth.bsky.social is not only attending #SFG2025 - he helped organize Glycopalooza events for early career researchers and is presenting poster B10-110 Tuesday. Check it out in session 2 to hear his impressive work integrating bottom-up and top-down methods to define glycoproteoform heterogeneity

The overlap of #HUPO2025 with #SFG2025 this week means I’m missing out on the #glycotime fun at SFG in San Diego.

I am happy postdoc @timveth.bsky.social is able to represent @riley-research.bsky.social at SFG instead!

Clearly my Toronto sources were wr❄️ng

If you are at #HUPO2025 and want to see some recent work from @riley-research.bsky.social, come check out Kayla’s talk on Monday afternoon in the Glycoproteomics session in the Frontenac Ballroom!

My poster on our recent work informatics tools is on Monday afternoon too. See you there!

#glycotime

You made a convincing case that I was missing out on your critical updates and (more importantly) Bluesky zingers

If you are at #HUPO2025 and want to see some recent work from @riley-research.bsky.social, come check out Kayla’s talk on Monday afternoon in the Glycoproteomics session in the Frontenac Ballroom!

My poster on our recent work informatics tools is on Monday afternoon too. See you there!

#glycotime

Understanding m/z range settings for MS/MS scans: a case study with intact glycopeptides chemrxiv.org/engage/...

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#proteomics #prot-preprint

Our manuscript describing @riley-research.bsky.social's GlyCounter informatics tool is now in press at Molecular and Cellular Proteomics. Congrats to first-author Katie Kothlow, her first first-author paper!

The manuscript is available here: www.mcponline.org/article/S153...