ASBMB Journals

Figure 1. Schematic representation of non-canonical translation initiation sites.

MCP Press| Chasing the Ghost Proteome in the Dark matter.
Learn more:
www.mcponline.org/ar...
#molcellprot

Overview of the stepwise filtering and ranking process for the identification of potential O. volvulus biomarkers among human plasma proteomics samples. PSM, peptide-spectral matches.

This study identifies a promising set of proteins for developing assays to diagnose onchocerciasis (causing severe dermatitis and blindness) and monitor treatment efficacy: www.mcponline.org/article/S153....

#MolCellProt #BlindnessAwarenessMonth

Widespread deployment of the human CD38 ADP-ribosyl cyclase fold in antibacterial and anti-eukaryotic polymorphic toxins Bacterial polymorphic toxins are modular weapons that mediate intermicrobial competition and host interactions by delivering diverse cytotoxic domains through specialized secretion systems. Here, we i...

Widespread deployment of the human CD38 ADP-ribosyl cyclase fold in antibacterial and anti-eukaryotic polymorphic toxins - Journal of Biological Chemistry www.jbc.org/article/S002...

Mechanistic insights into the selective targeting of P2X3 receptor by camlipixant antagonist ATP-activated P2X3 receptors play a pivotal role in chronic cough, affecting more than 10% of the population. Despite the challenges posed by the highly conserved structure of P2X receptors, efforts t...

Mechanistic insights into the selective targeting of P2X3 receptor by camlipixant antagonist - Journal of Biological Chemistry www.jbc.org/article/S002...

Synergy between RNA editing and alternative splicing modulates the biological properties of the voltage-gated calcium channel CaV1.3 Alternative splicing and adenosine-to-inosine (A-to-I) RNA editing are post-transcriptional mechanisms that promote proteomic diversity in the brain. The impact of RNA editing on brain physiology is u...

🚨 New paper alert! 🚨

Our paper entitled: "Synergy between RNA editing and alternative splicing modulates the biological properties of the voltage-gated calcium channel CaV1.3" is out now on Journal of Biological Chemistry!

www.jbc.org/article/S002...

#AlternativeSplicing #RNAediting

🧵 👇

Cyanophycinase is required for heterotrophy in cyanobacteria Cyanophycin is a biopolymer of arginine and aspartate, and it is found in various prokaryotes. Two key enzymes of cyanophycin metabolism are cyanophycin synthase (CphA) producing cyanophycin, and cyan...

Cyanophycinase is required for heterotrophy in cyanobacteria - Journal of Biological Chemistry www.jbc.org/article/S002...

Architecture kinases and pseudokinases.

Spend #Halloween with zombie proteins! Originally thought to be dead evolutionary remnants, #pseudokinases have since been revealed to play remarkably diverse noncatalytic roles in biological pathways.

🧟‍♂️ Learn more in this #JBiolChem review: www.jbc.org/article/....

Crystal structures of the Drosophila melanogaster Noppera-bo protein.

🎃 It’s #Halloween—perfect timing to highlight this #JBiolChem paper!

Explore "An integrated approach to unravel a crucial structural property required for the function of the insect steroidogenic Halloween protein Noppera-bo": www.jbc.org/article/....
#Drosophila #Enzymology

🔬 For more, delve into this paper published in Molecular & Cellular Proteomics ( @asbmbjournals.bsky.social): www.mcponline.org/article/S153....

Congratulations to @tkadava.bsky.social, @hecklab.bsky.social and colleagues on this fascinating work!

This 3D visualization of C4BP was created by Hecklab (Albert Heck) in collaboration with Sensu.health. C4BP uses its eight “legs” to catch proteins related to inflammation, stopping further immune response.

C4BP-C4b complexes visualized by high-speed atomic force microscopy.

#Halloween Trivia 🕸️ Did you know human blood contains spider-shaped proteins that help regulate the innate immune response?
🕷️Discover how C4BP uses its eight “legs” to catch proteins and control inflammation: www.asbmb.org/asbmb-....
#Immunology #MolCellProt #MassSpec

Figure 3. GREM1 uptake involves accumulation at the plasma membrane.

New in JBC press: "Identification of a novel GREMLIN1 uptake pathway in epithelial cells that requires BMP binding."
Learn more:
www.jbc.org/article/...
#jbiolchem

Fig. 1. Time-dependent effects of IL-1 on gene expression in islets.

New in JBC press: "Scientists explored the transcriptional responses of islets to endogenously produced cytokines following immune stimulation with the bacterial pathogen-associated molecular pattern lipopolysaccharide."
Learn more:
www.jbc.org/article/...
#jbiolchem

Figure 6. Structural analysis of DENN/MADD in complex with Rab GTPases.

Editors' Picks| Neurodevelopmental disorder mutations in the exchange factor DENN/MADD disrupt activation of Rab GTPases
Learn more:
www.jbc.org/article/...
#jbiolchem

Promotional graphic for ASBMB Journals' minicollection on automation and AI in biochemistry labs with a colorful molecular structure background.

AI is revolutionizing molecular life sciences — and the Nobel Prize recognized it. Dive into ASBMB’s free Automation & #AI in the Lab collection and catch the Deep Dive on AI at #ASBMB26.
💡 www.asbmb.org/annual-meeti...
📘 Free download via @asbmbjournals.bsky.social: www.asbmb.org/journals/min...

Improving the productivity and resilience of plants is crucial for addressing the food and climate challenges that the world is facing. This special issue of Molecular and Cellular Proteomics presents a wide range of proteomic studies in plants.
www.mcponline.org/sp...
#molcellprot

Figure 1. Overall workflow of pAb de novo sequencing with intact mass, targeted middle-down, and bottom-up MS data.

MCP press| Scientists present PolySeq.AI, an automated de novo workflow that combines bottom-up, middle-down, and intact mass analysis to accurately sequence pAb samples without relying on external databases."
Learn more:
www.mcponline.org/ar...
#molcellprot

Current and future applications of Class 1 systems.

It’s #WorldCRISPRday! To celebrate, revisit this #JBiolChem review: www.jbc.org/article/S002....

Tina Liu and @jenniferdoudna.bsky.social explore how Class 1 CRISPR-Cas systems are expanding possibilities for DNA/RNA editing, gene expression control and nucleic acid detection.

Creatine fuels cancer. In @asbmbjournals.bsky.social we show CKB drives CK activity in NSCLC, osteosarcoma & ovarian cancer, promoting metastasis & anoikis resistance. Led by postdoc Mouna Tlili, in collaboration with Peter Siegel + @mcgillgci.bsky.social. Preproof: www.jbc.org/article/S002...

Our work detailing the metabolic roles of serum for cancer cell proliferation is now out at JBC, @asbmbjournals.bsky.social!

Congrats to Oliver and Eric and many thanks to the editor and reviewers for a thoughtful and efficient review process.

See here:
www.sciencedirect.com/science/arti...

Figure 1 Cellular stability of pathogenic BTB domain mutations in KCTD1.

New in JBC press: "Pathogenic variants in KCTD1 disrupt cAMP signaling and cellular communication associated with developmental pathways."
Learn more:
www.jbc.org/article/...
#jbiolchem

Antibiotic sensor directly binds drug in resistant bacteria Researchers at Drexel University uncover how the vancomycin-resistant bacterial sensor binds to the antibiotic, offering insights to guide inhibitor design that restores antibiotic effectiveness against hospital-acquired infections.

Inside #JBiolChem | Researchers at Drexel University uncover how the vancomycin-resistant bacterial sensor binds to the antibiotic, offering insights to guide inhibitor design that restores antibiotic effectiveness against hospital-acquired infections.

We are pleased to present this collection of recent research articles on proteomics, such as advances in proteomics technology, clinical proteomics and single-cell proteomics.
www.mcponline.org/re...
#molcellprot

JLR press| Scientists showed an intestinal trophic action of OCA that demonstrates a dual clinical benefit of NR1H4 agonism in the prevention of PNALD in pigs.
Learn more:
www.jlr.org/article/...
#jlipidres

Thank you to everyone who joined our recent committee meeting! #ASBMBJournals #JbiolChem

📸 Committee members here on #Bluesky: @chifungleephd.bsky.social, @marinaholz.bsky.social & @drohsopretty.bsky.social.

Eleven members of the ASBMB Membership Committee smile and pose for a group photo at ASBMB's offices. They are standing in front of a bookcase lined with issues of the Journal of Biological Chemistry.

Members of the ASBMB Membership Committee gather around a member who is holding a copy of the first issue of the Journal of Biological Chemistry, which was published in Oct. 1905. They issue of the journal is opened and two members are taking photos on their phones.

Today's #TBT post celebrates 120 years of the Journal of Biological Chemistry! The first issue of JBC was published in Oct. 1905. Here's the ASBMB Membership Committee w/a copy of that first issue! It was a fun moment looking back as the membership committee looks to the future.
asbmb.org/membership

Copper acquisition in Bacillus subtilis involves Cu(II) exchange between YcnI and YcnJ The transition metal copper is biologically essential across all three domains of life. Several copper-dependent proteins and enzymes produced by the Gram-positive bacterium Bacillus subtilis have bee...

Copper acquisition in Bacillus subtilis involves Cu(II) exchange between YcnI and YcnJ

#JBiolChem from @fisherlab.bsky.social
with @johnhelmann.bsky.social

www.jbc.org/article/S002...

Detoxification of deoxynivalenol by pathogen-inducible tau-class glutathione transferases from wheat Deoxynivalenol (DON) is a toxicologically relevant trichothecene mycotoxin frequently found in cereal products. It is a virulence factor produced by the plant pathogen Fusarium graminearum during cere...

Detoxification of deoxynivalenol by pathogen-inducible tau-class glutathione transferases from wheat #JBiolChem #MassSpec www.jbc.org/article/S002...

Now out at #jbiolchem www.sciencedirect.com/science/arti...

AI-designed biomarker improves malaria diagnostics Researchers from the University of Melbourne engineered Plasmodium vivax diagnostic protein with enhanced yield and stability while preserving antibody-binding, paving the way for more reliable malari...

Inside JBC | Researchers from @wehi-research.bsky.social engineered Plasmodium vivax diagnostic protein with enhanced yield & stability while preserving antibody-binding, paving the way for more reliable malaria testing.
ow.ly/3asn50X8Orx #InfectiousDiseases #AI #JBiolChem @asbmbjournals.bsky.social

Rules of engagement: determinants of chemokine receptor activation and selectivity by CCL27 and CCL28 The distinct functional roles of chemokines CCL27 and CCL28 in epithelial immunity of skin and mucosal tissues, respectively, are coordinated by their shared receptor, CCR10, and the CCL28-specific receptor, CCR3. To identify determinants of receptor activation, internalization and binding specificity, we conducted structure-function studies focused on the N-termini of these two chemokines. Deletion of two N-terminal residues of CCL27 resulted in a CCR10 antagonist, highlighting the critical roles of these residues in driving receptor pharmacology.

New in JBC press: "Scientists' data illustrate how the modular nature of these chemokines enables their overlapping but non-redundant functions."
Learn more:
www.jbc.org/article/...
#jbiolchem