Dr Samuel J Pearce

Closure of the Fleming Fund risks undermining UK leadership on AMR - The British Society for Antimicrobial Chemotherapy

"Closure of the Fleming Fund risks undermining UK leadership on AMR." BSAC is seeking urgent clarification from the Government regarding the UK’s future leadership on antimicrobial resistance (#AMR), following reports that the Fleming Fund – the UK’s flagship global AMR programme – is set to close.

‘MMR vaccination uptake rate for children by the age of five in Liverpool is just 73% ... The World Health Organisation says a threshold of 95% is needed to achieve herd immunity’

Please protect child by allowing them to be vaccinated. If you are worried, talk to your doctor. Misinformation kills.

A couple of years ago, I bought the book Why I'm No Longer Talking to White People About Race by Reno Eddo-Lodge. I'm ashamed to say I haven't read it until now. If you haven't, I recommend you do. Today, I'm committing to monthly donations to the British Veterinary Ethnicity and Diversity Society.

Springer Nature Discovers MDPI – The Strain on Scientific Publishing Home page for the paper ‘The Strain on Scientific Publishing’ by Mark A Hanson, Dan Brockington, Paolo Crosetto and Pablo Gomez Barreiro

Springer-Nature launched a series of "Discover" journals that closely mimic MDPI titles -- sharing *identical* journal names, and likely similar business model.

What is going on, and why researcher will - as always - fall for it?

A 🧵

the-strain-on-scientific-publishing.github.io/website/post...

#OneHealthEvent
One Health Investigations of Outbreaks and Spillover Events - on Coursera is a course of 10 content modules and didactic lectures.

Find more:
www.coursera.org/learn/one-he...

#OneHealth #OneHealthResources

Excited to share the first beta release of AMRrules at #ABPHM! (Poster 42 tonight)
interpretamr.github.io/AMRrules

The new version of R for AMR is ready!

🧫 Automated antibiograms

💻 Integration to WHONET

🧪 Updated CLSI and EUCAST breakpoints

💡 Free

amr-for-r.org

#biostatistics #episky #Statistics #AMR

Effect of host microenvironment and bacterial lifestyles on antimicrobial sensitivity and implications for susceptibility testing npj Antimicrobials and Resistance - Effect of host microenvironment and bacterial lifestyles on antimicrobial sensitivity and implications for susceptibility testing

Absolutely thrilled to present our latest review, where we discuss how host microenvironment and bacterial subversion strategies can undermine traditional antimicrobial sensitivity testing, and whether better models may one day get us "beyond the MIC" #IDSKy
rdcu.be/emYoh

Just got back from my own Stag Do, on a beautiful bank holiday weekend, to find out that I am now officially a resident of the European College of Veterinary Microbiology!

🐶🐱 Companion animals need #AntimicrobialStewardship too! In our new SR/MA (led by Dr. Fiona Emdin), we examined short vs. long antibiotic durations for UTIs in dogs & cats.📉 Pooled RR for cure = 0.55 (95% CI: 0.23–1.27), very low certainty.
🔓 doi.org/10.1186/s129...
More high-quality data needed!

The promise and compromise of the WHO Pandemic Agreement for spillover prevention and One Health As scientists, health professionals, and lawyers engaged in reducing pandemic spillover risks, we recognise the urgent need for, and immense potential of, a robust international agreement on pandemic ...

Sharing our new @thelancet.bsky.social piece on spillover prevention & #OneHealth in the WHO #PandemicAgreement. We call on states to adopt the agreement next month. Huge thanks to @alexandrafinch.bsky.social for leading this. Let's get this done and make the world a safer place! bit.ly/3E7RKeu

Thanks for clarifying! Silly question to follow, do you use the uncomplicated UTI breakpoint for other abx for pyelo or prefer non-uti if possible? Just thinking that NICE recommendation of cefuroxime IV/co-amox PO suffers similar issues for non-uti breakpoints

This is kinda where I'm coming from too. Quinolines are favoured in VetMed and I was looking for an alternative to reduce HPCIA use. Wondered if the quinoline thing was dogma after seeing the NICE guideline but the evidence for cephs isn't helping my argument as much as I thought it would 😕

Yeah I do wonder if that's the case sometimes. What's your IV drug of choice? Cefuroxime seems to suffer the same problems but NICE has several other options

Ah my favourite podcast duo to learn AMS from the other side! I must confess, looking through that thread I realised I saw it the first time... And forgot about it 🤦 Does mean the second read was just as interesting though 😂

A pharmacokinetic-pharmacodynamic assessment of oral antibiotics for pyelonephritis - European Journal of Clinical Microbiology & Infectious Diseases Antibiotic resistance to oral antibiotics recommended for pyelonephritis is increasing. The objective was to determine if there is a pharmacological basis to consider alternative treatments/novel dosi...

Sounds interesting! What dose and MIC are you using out of curiosity? This PKPD study suggests NICE doses may hit MICs anywhere from <2 to <16 (link.springer.com/article/10.1...). I will hold my hands up and say my pharmacology needs dusting off though so willing to be told otherwise 🙌

Was thinking of a comparative article on beta-lactams use for pyelonephritis as NICE recommends PO cefalexin but upon reading the literature, I can't make it make sense 🤷 EUCAST only has a UTI breakpoint, PKPD suggests poor empirical choice, but clinical studies seem ok. Can #IDSky help me out here?

Stewardship solutions #3 Viral meningitis, FIP treatment durations and disinfectants for viruses

A month ago I started a fortnightly newsletter on veterinary infections disease, clinical microbiology and antimicrobial stewardship🦠This week covered some latest updates in small animal viral diseases, check it out here: open.substack.com/pub/resistan...

#VetSky

Biodiversity loss in all species and every ecosystem linked to humans – report Sweeping synthesis of 2,000 global studies leaves no doubt about scale of problem and role of humans, say experts

Humans are driving biodiversity loss among all species across the planet, one of the most exhaustive global studies on the subject ever conducted finds.

This is *us*, people: you + me. It's up to all of us to get into the fight for the natural world. 🌏
www.theguardian.com/environment/...

World’s first case of bird flu in sheep detected in England H5N1 virus found in single animal in Yorkshire but risk to general public is very low, say experts

What I don’t get is why the official position continues to be…

“…the risk to livestock and the general public is low.”

This variant of influenza seems to infect everything…how is that a low risk?

www.theguardian.com/world/2025/m...

Sensitivity and specificity answer the wrong questions Why how we measure a diagnostic test and how we interpret them are equally important

Recently, I was asked for my opinion on a novel veterinary UTI diagnostic. While the technology is fascinating, it is a good example of why sensitivity and specificity aren't always the best measure. Read more in my latest post here: resistanceisfutile.substack.com/p/sensitivit...

#vetsky #IDsky

Was a great event! Fascinating to see so many different aspects of AMR research

Challenges in human and veterinary primary care: What can we learn from the other? This meeting aims to offer participants a dynamic conference where experts from veterinary and human health fields connect.

Normal URL here: www.rsm.ac.uk/events/compa...

Picture showing details for the royal society of medicine event "challenges in human and veterinary primary care: what can we learn from the other?" May 12th 2025 online

Interested in One Health or ever wondered what primary care is like on the other side?

Check out this event from Royal Society of Medicine discussing the challenges seen in human and veterinary primary care! #MedSky #VetSky #OneHealth

lnkd.in/edfazfmQ

Emerging Cases of Cat-Transmitted Sporotrichosis Driven by Sporothrix brasiliensis in Northeast Brazil - Mycopathologia Cat-transmitted sporotrichosis is caused by the emerging fungal pathogen Sporothrix brasiliensis and constitutes a significant public health issue that affects people living in resource-poor urban cen...

Emerging #Sporothrix brasiliensis is fueling a cat-transmitted sporotrichosis #outbreak in Northeast Brazil. Over 1,100 cases identified in Recife's metro region (2016-2021), with zoonotic transmission linked to Rio de Janeiro strains.
Link: link.springer.com/article/10.1...
#PublicHealth #Zoonoses

The dynamic lung microbiome in health and disease - Nature Reviews Microbiology Like the gut, the lung harbours a diverse, interacting assortment of microbiota. In this review, Natalini, Singh and Segal examine the role of the lung microbiome in health and disease and discuss fut...

I think one of the biggest lies we were told in medical school is that the lungs and the urinary tract are sterile... I guess lung and urinary microbiomes were not a thing yet...

#meded #medsky #foamed #idsky

www.nature.com/articles/nru...

www.nature.com/articles/s41...

Cell-autonomous innate immunity by proteasome-derived defence peptides - Nature Proteasomal degradation of cellular proteins&nbsp;generate defence peptides constitutively and in response to bacterial infection.&nbsp;Such peptides might provide a source of natural antibiotics that...

A previously unknown immunological function of the proteasome is its ability to release bactericidal compounds. This discovery presents a potential paradigm shift in antimicrobial therapy. It may contribute to addressing the global challenge of #AMR.

www.nature.com/articles/s41...

Stewardship Solutions #1 Essential updates in veterinary infectious diseases

Long-form articles take time. In an effort to be more active I'm introducing Stewardship Solutions, I fortnightly short articles with brief tips and info for veterinary infectious diseases and antimicrobial stewardship #VetSky #IDsky #MicroSky

open.substack.com/pub/resistan...

When cultures lie A Guide to Diagnostic Stewardship

Taking a break from antimicrobial stewardship to talk about diagnostic stewardship and decision making (it's really just antibiotic stewardship in disguise 🤫). Urine samples make a great model for this as the interpretation can vary massively by sampling method!

open.substack.com/pub/resistan...

Seven reasons for keeping Elon Musk as a Fellow of the Royal Society Last November, I wrote a blogpost explaining why I had resigned as a Fellow of the Royal Society (FRS). In brief, over the summer a group ...

Latest blogpost on Musk/Royal Society debacle: deevybee.blogspot.com/2025/02/seve... I look at the reasons that have been given for inaction, and find them wanting. @royalsociety.org