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Diagnosis and characterization of people with #ME/CFS (vs controls) using circulating cell-free RNA, indicative of immune system dysfunction and pro-inflammatory cytokine signaling
www.pnas.org/doi/10.1073/...

The marine heat wave in the North Pacific is one of the most extensive, spanning the giant N Pacific, and in spots, the most intense, I’ve observed. Anomalies near Japan are 15 F (8C) above normal. (Japan just recorded its hottest temp on record.)
The reason for this N Pacific heat wave is… 1/

Low-dose metformin requires brain Rap1 for its antidiabetic action Metformin lowers blood glucose by inhibiting Rap1 in ventromedial hypothalamic neurons that regulate glucose balance.

Metformin, the first line drug for Type 2 diabetes, has been used for 60 years without a clearcut mechanism of action. It turns out it's not just reducing glucose output from the liver. Metformin also works via the brain www.science.org/doi/10.1126/...

The Earth has two massive 'superplumes' rising beneath Africa and the Pacific, surrounded by about ten mantle plumes each.
These antipodal magma domes are the origin of some of the most ferocious volcanic hotspots on the planet.
www.sciencedirect.com/science/arti...

A series of photos of the NYC Ballet's production of A Midsummer Night's Dream. They look like an impressionistic painting.

A series of photos of the NYC Ballet's production of A Midsummer Night's Dream. They look like an impressionistic painting.

A series of photos of the NYC Ballet's production of A Midsummer Night's Dream. They look like an impressionistic painting.

"If we shadows have offended, Think but this, and all is mended, That you have but slumber'd here While these visions did appear."

The NYC Ballet is doing some amazing & fantastic things with set design and costuming. Hard to believe these aren't paintings.

Record Mediterranean Sea #heatwave intensifying at 6C (10F) + above normal!
It’s not coincidence, it’s climate change.
Research shows a huge increase since the 1980s.
In fact, the long-term warming trend explains over 90% of the increase in MHW frequency, intensity, and duration. #EU #Europe

This is wild!
Engineering E. coli bacteria to turn plastic waste into paracetamol (Tylenol)
www.nature.com/articles/s41...
www.nature.com/articles/s41...

What COVID-19 Does to the Body (Eighth Edition, June 2025) Your Regular COVID-19 Research Update (90+ Studies)

🧪 NEW: What COVID-19 Does to the Body (Eighth Edition, June 2025)

Highlighting over 90 recent studies on COVID-19's impacts, organized by organ & topic, as well as research on methods to prevent SARS-CoV-2 transmission.

👇 READ, SUB (25% off!), SHARE WIDELY: www.panaccindex.info/p/what-covid...

The Gut-Brain Axis Takes Center Stage A rapid expansion of new discoveries and knowledge lays the foundation for a new era in medicine

Spotlight on the gut-brain axis
A rapid expansion of new discoveries and knowledge lays the foundation for a new era in medicine
erictopol.substack.com/p/the-gut-br...

The Atlantic's chilling secret: A century of data reveals ocean current collapse A century-old mystery of a stubborn cold patch in the North Atlantic is finally being unraveled. A new study links this anomaly to a long-term weakening of the Atlantic Meridional Overturning Circulat...

A study confirms what we have long argued: the spectacular Atlantic 'cold blob' is the result of a slowing of the Atlantic overturning circulation #AMOC, which transports warm waters into that region. That's the only part of Earth that resisted #globalwarming. 🌊
www.sciencedaily.com/releases/202...

Comprehensive evaluation of plasma tau biomarkers for detecting and monitoring Alzheimer’s disease in a multicenter and multiethnic aging population - Nature Aging Lan et al. demonstrate the high performance of plasma p-tau217 in detecting and tracking multiple aspects of Alzheimer’s disease pathology, outperforming other plasma tau biomarkers across two Chinese...

p-tau217, the breakthrough blood biomarker for Alzheimer's, picks up risk the earliest and its performance surpasses all other tau biomarkers, across ancestries
www.nature.com/articles/s43...
My review erictopol.substack.com/p/the-breakt...

There is still beauty in the world. (photographer unknown.)

The perfect tornado.

16mm full wide. Dickens, Nebraska. 6/16/25

Feline Health Center initiative to track avian flu spread in cats | Cornell Chronicle When cats get sick with H5N1 avian influenza, they get severely ill, with up to 70% of affected cats dying, but little is known about how the virus spreads in cats.

Cornell has launched a feline bird flu surveillance project! news.cornell.edu/stories/2025...

Microvascular obstruction is known to be a #LongCovid feature. Now a potential mechanism found for the obstruction induced by death of endothelial cells->sticky red blood cells. Which wouldn't respond to blood thinners or anti-platelet Rx
www.nature.com/articles/d41...
www.nature.com/articles/s41...

It's no longer binary: normal or abnormal.
We've known that A.I. can predict future risk of breast cancer from a mammogram
jamanetwork.com/journals/jam...
Today the FDA approved an A.I. to do this for 5-year risk assessment
clairity.com @connielehman.bsky.social

How ‘Inflammaging’ Drives Cancer—and Points to New Treatments Inflammation fuels the high rate of cancer in people over 50, researchers find, leading them to test anti-inflammatories like allergy drugs to fight it.

This is part of the "inflammaging" story that drives cancer and other age-related diseases
gift link www.wsj.com/health/infla...

With my forecast for May CO2 of 430.51 ppm, here's a look at the gain (in ppm) between yearly maximums, where for each year I take the maximum CO2 for that year and subtract the maximum CO2 from the previous year.

With a gain of 3.60 ppm, 2025 came in second to 2016, which had a gain of 3.75 ppm.

First Phase 2 randomized trial of engineered T cells for a solid tumor—GI cancer— with some encouraging results
www.thelancet.com/journals/lan... @thelancet.com

"The Microbiome for Clinicians" a new, open-access review of progress, limitations, and next steps
@cellpress.bsky.social
www.cell.com/cell/fulltex...

Americans Don’t Eat Enough Fiber. Here’s Why That Worries Nutrition Experts The latest science suggests our fiber-poor diets trigger inflammation and contribute to a range of related diseases.

"Protein may be hot, but it’s fiber that Americans need to eat a lot more of."
"To get the full health benefits of fiber, it’s important to eat a variety of naturally fiber-rich foods and not rely on supplements...could actually lead to health problems..."
gift link www.wsj.com/health/welln...

Large-scale plasma proteomic profiling unveils diagnostic biomarkers and pathways for Alzheimer’s disease - Nature Aging Heo, Xu et al. used comprehensive plasma proteomics to identify 416 plasma proteins (294 new) associated with Alzheimer’s disease and applied machine learning to select 7 proteins that were highly pre...

Our ability to accurately predict #Alzheimer's disease years in advance of any symptoms keeps getting better with plasma proteins and A.I. analytics @nataging.nature.com
www.nature.com/articles/s43...

Why does evolution matter for psychiatry, psychology and medicine? 🏺🧪

Today the 1st case of CRISPR 3.0 (Prime genome editing) announced for a teenager with chronic granulomatous disease
www.nature.com/articles/d41...

And who funded this work…? NSF funded all the US Antarctic ice cores (💚🩵) & NOAA funds Mauna Loa (🖤). Antarctic ice is the only archive clean enough to preserve unaltered air in bubbles in the ice.

Five things you need in case of a power outage People in Spain and Portugal tell us what got them through a day with no electricity.

Five things you need in case of a power outage

The Best and Worst Habits for Your Teeth (Gift Article) Dentists talk charcoal toothpastes, flavored coffees, post-meal water rinses and more.

Having written BITE, a book about teeth, I thought I'd post this article on some dental does and don'ts. 🧪

Drivers of female power in bonobos - Communications Biology In mammals, documented female dominance is rare, but females can hold high status even with male-biased dimorphism. In wild living bonobo groups, female coalition formation best explains the observed ...

🧪This is interesting! Bonobos, a species of endangered apes, only found in the Dem Rep of Congo, live in female dominated societies. This paper supports the thought that females form coalitions to sustain their matriarchies. This affirms 30 yrs of research.

🔗 www.nature.com/articles/s42...