Brigette D. Manohar

Efficient in vivo mammalian neuron editing using peptide-mediated CRISPR enzyme delivery CRISPR-mediated genome editing of the central nervous system (CNS) has the potential to revolutionize the treatment of neurological disorders, including neurodegenerative disorders such as Huntington’...

Non-viral delivery of CRISPR components to the brain using peptide-enabled ribonucleoproteins

www.biorxiv.org/content/10.1...

15.12.2025 22:20 — 👍 2    🔁 1    💬 0    📌 0

Honored that this work represents my first "first-author" preprint of my PhD journey at
@berkeleymcb.bsky.social. Grateful for the incredible mentorship and collaborations. Neuro-PERC was a true multi-institution effort. Read the thread for the details!

02.12.2025 19:05 — 👍 1    🔁 1    💬 0    📌 0

Huge credit to @bmanohar.bsky.social for leading this collaborative effort, based at @innovativegenomics.bsky.social & @berkeleymcb.bsky.social, with major contributions from OSU's Krys Bankiewicz & Russ Lonser, as well as crucial support from NIH's SCGE consortium @scge.bsky.social

02.12.2025 09:11 — 👍 3    🔁 3    💬 0    📌 0

Efficient in vivo mammalian neuron editing using peptide-mediated CRISPR enzyme delivery https://www.biorxiv.org/content/10.1101/2025.11.26.690638v1

30.11.2025 01:15 — 👍 6    🔁 2    💬 0    📌 0

Sweater weather ☃️❄️

02.12.2025 02:39 — 👍 2    🔁 0    💬 0    📌 0

A puzzling, 3.4-million-year-old fossil foot belonged to a contemporary of the famed Lucy Identity of the toe bones and other fossils could shake up the human family tree

Newly discovered fossils tie this foot to a primitive human relative known as Australopithecus deyiremeda, an enigmatic contemporary of A. afarensis, whose species included the famed Lucy skeleton. https://scim.ag/4414MEj

01.12.2025 23:30 — 👍 35    🔁 5    💬 0    📌 0

For the second year in a row, IGI had a booth at #NDiSTEM, the annual conference from SACNAS! More than a hundred students stopped by to learn about IGI and opportunities at the University of California.

26.11.2025 16:02 — 👍 2    🔁 1    💬 0    📌 0