Cambridge Institute for Medical Research

Two female scientists in a research lab

Just a couple of weeks left to apply for our taught Masters in the Molecular Mechanisms of Human Disease. All details here: www.cimr.cam.ac.uk/postgraduate...
Apply by the funding deadline, 2nd December

The Cambridge Biomedical Campus Open Mic returns! With a fully stocked bar and food on sale, whether you’re performing or just soaking up the atmosphere, everyone is welcome – you don’t need to work at the Biomedical Campus to join in!

Find out more: cambridge-biomedical.com/event/open-m...

Two female scientists in a laboratory discussing an experiment

Our mission is to determine the molecular mechanisms of disease in order to advance human health.
Want to join our vibrant and diverse research institute as a funded PhD or taught MPhil student? Apply by the 2nd December 2025.
More information here: www.cimr.cam.ac.uk/postgraduate...

Darwin College team congratulating their opponents after winning this week's University Challenge

Great win for @darwincollegecam.bsky.social in last night's University Challenge - featuring CIMR PhD student Lewis Strachan. Well done team!

Fantastic news! Well done Lily

School pupils tour the Sherlock Library at St Catharine's during a visit

Spread the word! Outstanding UK students can experience life at Catz

@isaacphysics.org STEM SMART: apply by 31 Oct undergraduate.study....

@thecimr.bsky.social Inspiring Scientists: apply by 21 Nov cimr.cam.ac.uk/inspi...

@cam.ac.uk Bangla Soc Access Day: apply by 15 Dec forms.gle/KReLakbpAS...

The beginning of a new era. Behold the Dickens lab @thecimr.bsky.social - small but perfectly formed. Excited for what is to come! Thanks @profmarciniak.bsky.social for letting me squat until now…

The ARUK stand in the calm before it began, with our activities and 3D printed brains

People hard at work building molecules

Plasticine cells being made

Microscopes with tissue sections

As always, the Big Biology Day at Hills Rd Sixth Form was an absolute blast! A great morning with @alzheimersresearchuk.org and a great afternoon with @thecimr.bsky.social

An abstract image formed of an array of triangles in the shape of a forward facing arrow. Some of the triangles contain pictures from the previous summits, illustrating the talks, exhibitions and conversations. Text: Thurs 6 November at Hinxton Hall, Wellcome Genome Campus.

The #RAREsummit25 agenda is live!
Packed with diverse voices, patient-driven insights & bold innovation.
www.camraredisease.org/raresummit25...
Grab your ticket to join us on 6 Nov to be part of the conversation & on't forget to book your dinner spot!

What are you most looking forward to?

We've just welcomed this year's cohort of MPhil students studying the Molecular Mechanism of Human Disease so it's time to start preparing for next year! Applications are now open - details and link to apply here: www.cimr.cam.ac.uk/masters-mole...

Only two more days to go!! This Saturday from 10am to 4pm at Hills Road Sixth Form @thecimr.bsky.social will be joining Big Biology Day. Come along and bring your #family to join in lots of #fun #science activities.

A montage of images of sixth form students in a Cambridge research lab

Applications now open for our work experience programme for year 12 students, run with @mrc-mbu.bsky.social & @stcatharines.bsky.social We give students a valuable insight into life as a research scientist and student in Cambridge. Details & application link here: www.cimr.cam.ac.uk/inspiring-sc...

Group of university students gathered on a staircase and landing

Great to welcome our second cohort of students to our Masters in Molecular Mechanism of Human Disease today. Have a good year everyone!

We're looking forward to the Big Biology Day at Hills Road Sixth Form on Saturday 11th October - who's coming?

*job alert**
Wanted - 2 enthusiastic postdocs to join me @thecimr.bsky.social and Emma Rawlins @labrawlins.bsky.social to build complex models and use -omic approaches to understand mechanisms in human lung disease in collaboration with GSK. Contact us for more info!
www.jobs.cam.ac.uk/job/52936/

Great new paper highlighting @jenniferepalmer.bsky.social 's PhD work: www.cimr.cam.ac.uk/research-adv...

New JCS snapshot - Cytotoxic T lymphocytes adapt to the loss of Cdc42
@adamrochussen.bsky.social presents the key findings from their recent JCS paper with Claire Ma and Gillian Griffiths @griffithslab.bsky.social.
journals.biologists.com/jcs/article/...

🧠 Cambridge scientist reveals how autophagy clears toxic proteins in neurodegeneration in Genomic Press Interview. Dr. Rubinsztein's breakthrough: cellular cleanup fights Huntington's, Parkinson's & Alzheimer's! 134k+ citations 🔬✨
📄🆓 DOI: doi.org/10.61373/bm0...
Source: genomicpress.kglmeridian.com

Multi-panel figure showing that CTL function improves days after deletion of Cdc42.

. @adamrochussen.bsky.social, Claire Ma & Gillian Griffiths @griffithslab.bsky.social find that deletion of Cdc42 in primary T cells triggers transcriptional adaptation, leading to enhanced T cell function.
journals.biologists.com/jcs/article/...
Article: journals.biologists.com/jcs/article/...

Sometimes, knocking out a gene isn't a good way to figure out the function of that gene ...

In our new @jcellsci.bsky.social paper, we report potent transcriptional adaptation by cytotoxic T lymphocytes (CTLs) in response to CRISPR/Cas9-mediated deletion of the important polarity protein CDC42 🧵⬇️

Great news² 🥳

Clinical PhD student Niki Veale has just passed his PhD viva so will become Dr Dr Veale (Dr² Veale)

We’ve also learned that he’s secured a Clinical Lectureship so will return to the lab as a post-doc (or is that post-doc-doc?)

@thecimr.bsky.social
@veale-n.bsky.social

Congratulations Adam!

Endogenous gene editing of alveolar organoids reveals that expression of pathogenic variant SFTPC-I73T disrupts endosomal function, epithelial polarity and wound healing Background: Idiopathic pulmonary fibrosis is a fatal lung disease of progressive lung parenchymal scarring caused by the aberrant response of an alveolar epithelium repeatedly exposed to injury. Under...

New preprint alert! Endogenous gene editing of alveolar organoids to investigate mechanisms of epithelial dysfunction in familial ILD. Kudos first author @eimearrutherford.bsky.social and thanks @thecimr.bsky.social @labrawlins.bsky.social @profmarciniak.bsky.social
www.biorxiv.org/content/10.1...

Heatwaves could bring deadly ‘tropical’ diseases to Britain A warming world is pushing tropical infectious diseases northwards as pathogens thrive in hot and humid conditions

Could climate change bring new diseases to the UK? Prof Michael Weekes spoke to @the-independent.com recently
www.independent.co.uk/climate-chan...

We had a such a great week with this lovely group of students on @gurdoninstitute.bsky.social ASTP programme- they did some fantastic presentations on Friday! Well done to all of them 👋👋👋

Such a rewarding experience to host these ASTP students and guide them through an exciting weak of science discovery @thecimr.bsky.social
I’m glad I could convey the importance of sterile conditions in cell culture 😂😂

We're loving hosting students for the @gurdoninstitute.bsky.social ASTP programme, along with @mrc-mbu.bsky.social . As ever, so impressed with the next generation of scientists!

Rounding up today's flurry of new papers is this one from the Salje lab www.cimr.cam.ac.uk/research-adv...

And another one from the very busy @deanelab.bsky.social - this time PhD work from Alex Nicholson
www.cimr.cam.ac.uk/research-adv...

New in from @deanelab.bsky.social www.nature.com/articles/s41...