Hubrecht Institute

Welcome to the Hubrecht Institute @leootsuki.bsky.social!

Together with his new team, Leo will study the molecular principles of tissue regeneration in the axolotl. Learn more about his work on our website www.hubrecht.eu/research-gro...

🧬 Looking for a PhD position in molecular or developmental biology? 🔬

✉️ The Hubrecht Institute now has its very own PhD program! Applications are open and will be accepted until September 15th. Read more here 👉 www.hubrecht.eu/hipp/

🧬 How do epigenetic modifications change over time in the same cell? Are they maintained during cell divisions?

Researchers from the Kind and Van Oudenaarden groups have found a way to study these types of questions: www.nature.com/articles/s41.... Read more below! 👇

@jopkind.bsky.social

Errors in DNA packaging – PhD defense Jan Dreyer Jan Dreyer successfully defended his PhD thesis entitled ‘Cellular response to defects in chromatin assembly’.

🧬 What do cells do when the packaging of their DNA goes wrong? During his PhD, Jan Dreyer found cells to be surprisingly quick in detecting errors and starting up rescue responses. Today he successfully defended his thesis. Congratulations Jan! 🎓 Read more here 👉 www.hubrecht.eu/phd-jan-drey...

Ina Sonnen earned tenure: 'science is like a puzzle' - Hubrecht Institute

What if science is like solving puzzles?

We spoke with @sonnenlab.bsky.social, a group leader who recently received tenure. She tells us about her journey, her research on signaling dynamics, and the challenges of leading a lab.

Read her inspiring story here 👇 www.hubrecht.eu/ina-sonnen-t...

Thesis cover image

🧬What makes one cell different from another? Kim de Luca developed methods that help answer this question. They can be used to study DNA organization, regulation and repair in single cells. Today she successfully defended her thesis. Congratulations Kim!🎓 Read more 👉 www.hubrecht.eu/phd-kim-de-l...

The Den Hertog group uncovered a surprising mechanism in zebrafish tail development: when cells from Kupffer’s vesicle fail to migrate, a second tail-like structure can form. The discovery emerged during a screen of fungal metabolites. www.hubrecht.eu/tail-develop... @dev-journal.bsky.social

A matter of distance – PhD defense Sjoerd Tjalsma Sjoerd Tjalsma successfully defended his PhD thesis entitled ‘Dissecting distance in enhancer-mediated gene regulation’.

🧬 Does it matter whether genes are switched on from close by or from a distance? That is the question Sjoerd Tjalsma set out to answer during his PhD. Last week, he successfully defended his thesis. Congratulations Sjoerd! 🎓 Read more here 👉 www.hubrecht.eu/phd-sjoerd-t...

Scientists discover new approach to gene therapy Researchers find a new method for gene therapy, ‘delete-to-recruit’, and show its potential for treating sickle cell disease and thalassemia.

Read more on our website! 👉 www.hubrecht.eu/new-approach-gene-therapy

On 🌎World Sickle Cell Day🩸 we share a new gene therapy approach that holds promise for patients with sickle cell disease, thalassemia and possibly other genetic diseases.🧬 Researchers from the Hubrecht Institute, Erasmus MC, Sanquin and Oncode found a new method to switch genes on.

Interactions of epigenetic layers – PhD defense Verity-Legg On June 19th, Joe Verity-Legg defended his dissertation 'Developing multi-omic single-cell and single-molecule methods'.

Congratulations to Dr. Joe Verity-Legg who successfully defended his PhD! He developed ChIMe-seq, a new method to study multiple epigenetic layers in single cells. It can be used to shed light on development and diseases such as cancer. Read more:

ERC Advanced grant for Geert Kops - Hubrecht Institute

🎉Congratulations Geert Kops! ERC Advanced grant to study structure of the centromere, a crucial chromosome region that ensures proper cell division

www.hubrecht.eu/erc-advanced...

@kopslab.bsky.social @erc.europa.eu @oncodeinstitute.bsky.social @knaw-nl.bsky.social @umcutrecht.bsky.social #ERCAdG

ERC Advanced grant for Geert Kops - Hubrecht Institute

🎉 Congratulations Geert Kops - ERC Advanced grant to study structure of the centromere, a crucial chromsome region that ensures proper cell division www.hubrecht.eu/erc-advanced...

@kopslab.bsky.social @erc.europa.eu @oncodeinstitute.bsky.social @knaw-nl.bsky.social @umcutrecht.bsky.social #ERCAdG

RNA transcripts regulate G-quadruplex landscapes through G-loop formation G-quadruplexes (G4s) are prevalent DNA structures that regulate transcription but also threaten genome stability. How G4 dynamics are controlled remains poorly understood. Here, we report that RNA tra...

Excited our paper is out! G-quadruplex (G4) unwinding via an intricate G-loop assembly and disassembly mechanism maintains genome integrity. Pioneered by Koichi Sato with great collaborators Jing Lyu and @simonelsasser.bsky.social Check it out: www.science.org/doi/10.1126/science.adr0493 🧵(1/4)

Human airway submucosal gland organoids to study respiratory inflammation and infection Lin and Pou Casellas et al. established human airway submucosal gland (SMG) organoid cultures that capture region-specific mucous cells and viral infection responses. These SMG organoids provide a new...

Link to the article: www.cell.com/cell-stem-ce...

Organoid group researchers created mini airway submucosal glands, or organoids, that produce region-specific mucus and function just like real glands in our lungs. A powerful tool to study how our airways repair themselves, react to inflammation, and fight off viruses.
@cp-cellstemcell.bsky.social

Knot good: How cells untie DNA to protect the genome New work from the Knipscheer group reveals a mechanism involving RNA and DNA repair proteins that helps cells safely remove G-quadruplex (G4) structures.

New work from the Knipscheer group published in @science.org reveals a mechanism involving RNA and DNA repair proteins that helps cells remove G-quadruplex structures. G4 structures are knot-like formations in DNA that can cause damage if left unresolved. www.hubrecht.eu/cells-untie-dna-knots/

Congratulations to group leaders Matilde Galli, Ina Sonnen, and Francesca Mattiroli on receiving M-grants from the Dutch Research Council (NWO)! 🎉
With this funding, they’ll explore cell division, gut cell communication and DNA packaging.
Read more here 👉 www.hubrecht.eu/nwo-m-grants...

Today we introduce our new logo and visual identity!

Our new look is inspired by the tools and images we use to explore the molecular and developmental processes that shape life in the finest detail.

Learn more about the ideas behind our new identity: www.hubrecht.eu/new-look-hub...

15 Hubrecht colleagues climbed Alpe d’Huez yesterday to raise money for cancer research via www.opgevenisgeenoptie.nl & the Dutch Cancer Society (KWF), together with @oncodeinstitute.bsky.social. In total over €19M was raised, a 10 year record! 🧡 #AlpeDHuZes #CancerResearch #outsmartingcancer

#BOARD25 highlights the importance of being open about this kind of research.

Thanks @stichtinghartekind for the zebrafish images!

In the Netherlands, animal research is strictly regulated under the Experiments on Animals Act. No experiments are allowed unless they are essential and no alternatives exist, ensuring the responsible and ethical use of animals in science.

In the video, Federico, researcher in the Bakkers Group, explains how their transparency makes it easy to observe heart development in real-time under the microscope. This allows researchers to study heart function in ways that aren’t possible with other models.

Today, on ‘Be Open about Animal Research Day’, we spotlight how research with zebrafish brings us closer to healthier hearts. #BOARD25

Sharing about 80% of heart disease–causing genes with humans, the zebrafish is an excellent model to study how hearts develop, become diseased and might regenerate.

The Bakkers Group has a vacancy for a PhD position. Read more below!👇

Teamwork always wins, states @hansclevers.bsky.social in his reflection on research in pharma versus academia in ‪‪@natmed.nature.com.

"Revolutionary discoveries in science are truly enabled when we have open minds and ears to share and collaborate and remain open to new opportunities."

🧬Postdoc position alert! 🚨 We're hiring a postoc in Computational Modeling of Epigenetic Inheritance at the Hubrecht Institute (Alexander van Oudenaarden, Utrecht 🇳🇱) & Danish Cancer Institute (Anja Groth, Copenhagen 🇩🇰).

Come work in our collaberative team of top scientists

shorturl.at/avBBy

Congratulations to @bramverhagen.bsky.social who successfully defended his PhD on May 8th!

He developed a new tool, called RiboScan, which helped him discover new sequences in the mRNA that contribute to finding the start site of the coding sequence. See: https://www.hubrecht.eu/phd-bram-verhagen/

Our director Geert Kops @kopslab.bsky.social, has been elected member of the @knaw-nl.bsky.social for his contribution to the knowledge on cell division and chromosomal abnormalities in cancer. 

More on this honor and what a KNAW membership entails: www.hubrecht.eu/geert-kops-elected-KNAW-member

It's possible to apply for the Hubrecht Talent Program again!
The HTP aims to promote scientific excellence in the Netherlands by supporting talented minority students in pursuing a career in scientific research.

Read more in the flyer and on www.hubrecht.eu/about-us/hub...