ISACB

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Calcified Artery Preparation and Processing with Preserved Morphology and RNA for Digital Spatial Profiling

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Integrative Proteomic and Lipidomic Analysis of Post–Myocardial Infarction Patients Treated With PCSK9 Antibodies and Statins | Circulation: Genomic and Precision Medicine BACKGROUND: PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibition is a potent cholesterol-lowering strategy. This study examined the effects of PCSK9 monoclonal antibodies (mAbs) and high-i...

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Integrative Proteomic and Lipidomic Analysis of Post-Myocardial Infarction Patients Treated With PCSK9 Antibodies and Statins

www.ahajournals.org/doi/10.1161/...

Atherosclerotic Fibrous Plaques in Women Present ECM Remodeling Linked to TGF-β | Circulation Research BACKGROUND: Sex and atherosclerotic plaque histology are intertwined, with fibrous plaques being more prevalent in women. Plaque erosion, a significant contributor to acute coronary syndromes, is link...

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Atherosclerotic Fibrous Plaques in Women Present ECM Remodeling Linked to TGF-β

www.ahajournals.org/doi/10.1161/...

Leptin Activates Brain-BAT-Heart Crosstalk to Promote Cardiac Protection | Circulation Research BACKGROUND: Cardiovascular disease remains the leading cause of death worldwide, with coronary artery disease being the primary contributor. Our recent studies suggest that activation of LepRs (leptin...

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Leptin Activates Brain-BAT-Heart Crosstalk to Promote Cardiac Protection

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Quantification of Alpha-Gal Expression in Commercial BioProsthetic Heart Valves and Its Potential Mitigation Bioprosthetic heart valves (BHVs) are inherently susceptible to structural degeneration, driven by a combination of mechanical stress, lipid infiltration, glutaraldehyde-induced crosslinking instabili...

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Quantification of Alpha-Gal Expression in Commercial BioProsthetic Heart Valves and Its Potential Mitigation

www.structuralheartjournal.org/article/S247...

Bmp9 regulates Notch signaling and the temporal dynamics of angiogenesis via Lunatic Fringe Sprouting angiogenesis and blood vessel stabilization require precise coordination between endothelial cells (ECs) and pericytes. Bone Morphogenic Pro…

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Bmp9 regulates Notch signaling and the temporal dynamics of angiogenesis via Lunatic Fringe

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Cardiac Lymphatics Predict Survival After Heart Transplantation | Journal of the American Heart Association

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Cardiac Lymphatics Predict Survival After Heart Transplantation

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Model Choice and Interpretation in Coronary Tissue Engineering: Still More Questions Than Answers?

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Model Choice and Interpretation in Coronary Tissue Engineering: Still More Questions Than Answers?

www.jacc.org/doi/10.1016/...

Rat models for arterial calcification associated with chronic kidney disease: a systematic review and meta-analysis - BMC Cardiovascular Disorders Arterial calcification represents a major burden in chronic kidney disease (CKD) and is an independent risk factor for cardiovascular diseases (CVD). Rodent models are essential for preclinical resear...

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Rat models for arterial calcification associated with chronic kidney disease: a systematic review and meta-analysis

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Shear Stress Initiates Endothelial-to-Mesenchymal Transition in Endocardial Endothelial Cells - Annals of Biomedical Engineering Discrete subaortic stenosis (DSS) is a congenital heart disease in which a fibrotic membrane forms below the aortic valve; the underlying cellular mechanisms are currently unknown. Since an elevated p...

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Shear Stress Initiates Endothelial-to-Mesenchymal Transition in Endocardial Endothelial Cells

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Elevated asporin expression in human atherosclerotic plaques promotes their stability and reduces the risk for cardiovascular events AbstractAims. Vascular atherosclerotic calcification is a pathological process marked by the abnormal deposition of calcium minerals in the intima. Asporin

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Elevated asporin expression in human atherosclerotic plaques promotes their stability and reduces the risk for cardiovascular events

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Two Faces of Mitral Stenosis: Uncovering Structural and Hemodynamic Signatures of Rheumatic and Mitral Annular Calcification–Induced Disease | Journal of the American Heart Association

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Two Faces of Mitral Stenosis: Uncovering Structural and Hemodynamic Signatures of Rheumatic and Mitral Annular Calcification-Induced Disease

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Plasma and pericardial fluid metabolomic signatures of patients with ischemic heart disease - Communications Medicine De Castro, Coppola et al. analyze metabolic profiles in blood and pericardial fluid from patients with ischemic heart disease. They identify distinct energy-related changes that reflect myocardial str...

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Plasma and pericardial fluid metabolomic signatures of patients with ischemic heart disease

www.nature.com/articles/s43...

Frontiers | Arrhythmias across the tree of life: comparative insights for human electrophysiology IntroductionArrhythmias in non-human animals offer insights into human electrophysiology, yet physicians may be unaware of their occurrence and significance....

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Arrhythmias across the tree of life: comparative insights for human electrophysiology

www.frontiersin.org/journals/car...

Clinical proteomics in cardiovascular medicine: Current capabilities, limitations, and future directions Commercial high-throughput proteomics platforms, such as Olink and SomaLogic, enable large-scale epidemiological studies with integrated multi-omics measurements. While these proteomics approaches hav...

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Clinical proteomics in cardiovascular medicine: Current capabilities, limitations, and future directions

www.atherosclerosis-journal.com/article/S002...

Computational Optimization of a Stent for the Femoropopliteal Artery - Annals of Biomedical Engineering Purpose Clinical outcomes of peripheral artery disease (PAD) stenting, particularly in the highly dynamic regions of the femoropopliteal artery at the adductor hiatus and behind the knee, leave signif...

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Computational Optimization of a Stent for the Femoropopliteal Artery

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1-Phosphatidylinositol 3-Phosphate 5-Kinase Inhibition by Apilimod Promotes an Adipocyte-Like Vascular Smooth Muscle Cell Phenotype and Prevents Arterial Calcification

www.ahajournals.org/doi/10.1161/...

Omega-3 PUFAs reduce inflammation by targeting NRF2 and NF-κB activity in an ex vivo model of cardiac mature adipocytes and adipose derived stem cells from atherosclerotic patients Under proatherogenic conditions, epicardial (EAT) and pericardial adipose tissue (PAT) acquire inflammatory/pro-atherogenic phenotypes that contribute to coronary atherosclerosis. Recent data have hig...

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Omega-3 PUFAs reduce inflammation by targeting NRF2 and NF-κB activity in an ex vivo model of cardiac mature adipocytes and adipose derived stem cells from atherosclerotic patients

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Variant burden and severity of cardiomyopathy in patients with DMD-related Duchenne muscular dystrophy

www.nature.com/articles/s41...

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Investigating the role of structural wall stress in aortic growth prognosis in acute uncomplicated type B aortic dissection

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Myocardial Infarction Elicits a Robust Inflammatory Response in the Pericardial Space The pericardium and its contents, including pericardial fluid (PF), provide a homeostatic environment for optimal cardiac function. Since the heart is bathed in PF, the components of PF can potentiall...

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Myocardial Infarction Elicits a Robust Inflammatory Response in the Pericardial Space

onlinecjc.ca/article/S082...

Comprehensive Evaluation of Plasma Biomarkers in Patients with Abdominal Aortic Aneurysm Using High-Throughput Label-Free Quantitative Proteomic Profiling | American Journal of Physiology-Heart and Ci... The use of comprehensive unbiased proteomic evaluations coupled with physiological and clinical insight offers the possibility to enhance our understanding of disease mechanisms and identify potential...

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Comprehensive Evaluation of Plasma Biomarkers in Patients with Abdominal Aortic Aneurysm Using High-Throughput Label-Free Quantitative Proteomic Profiling

journals.physiology.org/doi/abs/10.1...

Vitamin‐B6 Pretreated Bovine Pericardial Bioprosthetic Heart Valve Leaflets Demonstrate Reduced Platelet Adhesion and Activation Bioprosthetic heart valves (BHV) fabricated from heterograft tissue such as glutaraldehyde fixed bovine pericardium (BP), while less thrombogenic than mechanical valve prostheses, nevertheless demons...

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Vitamin-B6 Pretreated Bovine Pericardial Bioprosthetic Heart Valve Leaflets Demonstrate Reduced Platelet Adhesion and Activation

onlinelibrary.wiley.com/doi/10.1002/...

Insights into arteriovenous fistula (non)maturation: single-cell transcriptomics reveals new drivers of arteriovenous fistula remodeling Single-cell transcriptomics of arteriovenous fistulas reveal that failure is likely driven less by smooth muscle proliferation than by continuous inflammation, endothelial dysfunction, and fibroblast-...

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Insights into arteriovenous fistula (non)maturation: single-cell transcriptomics reveals new drivers of arteriovenous fistula remodeling

www.kidney-international.org/article/S008...

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Translational Strategies for Developing and Evaluating Transcatheter Devices in Swine Heart Failure Models

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Robotically assisted, minimally invasive ascending aortic replacement: A feasibility study in anatomical models AbstractOBJECTIVES. Robotic cardiac surgery is well established in mitral valve repair and coronary artery bypass grafting. Outside of limited applications

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Robotically assisted, minimally invasive ascending aortic replacement: A feasibility study in anatomical models

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Miniaturized device for assessing calcification propensity of biohybrid implants under continuous flow Biohybrid implants are a promising development for cardiovascular disease treatment but suffer from problems like thrombogenesis and calcification. However, testing and validating biohybrid implants c...

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Miniaturized device for assessing calcification propensity of biohybrid implants under continuous flow

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Tissue regenerative medicine: Clinical advances, challenges, and opportunities Regenerative medicine is transforming how we restore tissue function, leveraging advances in cell and molecular biology, biomaterials, and engineered microenvir

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Tissue regenerative medicine: Clinical advances, challenges, and opportunities

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The RhoGEF Trio regulates the formation of tensile linear endothelial junctions to improve barrier function | Molecular Biology of the Cell The vascular endothelium serves as a selectively permeable barrier, tightly regulating transendothelial transport of small molecules, macromolecules, and immune cells. In the context of cardiovascular...

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The RhoGEF Trio regulates the formation of tensile linear endothelial junctions to improve barrier function

www.molbiolcell.org/doi/10.1091/...

Protocol for generating human vascular organoids via orthogonal activation of ETV2 and NKX3.1 Vascular organoids (VOs) are 3D multicellular constructs that model vascular development and function. Here, we present a protocol to generate VOs fro…

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Protocol for generating human vascular organoids via orthogonal activation of ETV2 and NKX3.1

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