JCI insight

Recurrent acute anterior uveitis frequently occurs in axial spondyloarthropathies.

Here, David A. Copland & team identify tissue-resident IL-23-responsive T cells in the eye as orchestrators of ocular inflammation: insight.jci.org/articles/vie...

Check our newest paper on how IPE (EPA-precursor) supplementation rapidly induces lipoprotein remodeling, and its impact on CVD risk markers in normolipidemic individuals:

insight.jci.org/articles/vie...

@katioorni.bsky.social #MedSky #CVD #Atherosclerosis #ScienceSky #Lipoproteins

CLN2 disease is a childhood-onset neurodegenerative lysosomal storage disorder caused by TPP1 deficiency, but little is known about the cellular cause.

Takahashi et al. show GABAergic interneurons contribute to the fatal seizure phenotype in CLN2 disease mice: insight.jci.org/articles/vie...

The effects of GLP-1RAs on lung cancer outcomes👇

Sai Yendamuri & team report GLP-1RAs suppress tumor growth selectively in obesity, enhance lung cancer-specific clinical outcomes, and augment immunotherapy efficacy: insight.jci.org/articles/vie...

Children treated with proton pump inhibitors for eosinophilic esophagitis often don’t respond

Chakraborty et al. analyzed biopsies from pediatric patients, revealing transcriptional signatures for PPI- responsive & -unresponsive eosinophilic esophagitis: insight.jci.org/articles/vie...

How are the collecting ducts of the kidney formed and maintained?

This issue’s cover features work by Karen I. López-Cayuqueo & team on the role of transcription factor TFAP2A in the architecture of the adult—but not embryonic—renal collecting duct: insight.jci.org/articles/vie...

How might air pollution contribute to insulin resistance?

Sanjay Rajagopalan & team demonstrate exposure to PM2.5 air pollution in mice leads to mitochondrial dysfunction in brown fat & metabolic dysfunction through epigenetic regulation: insight.jci.org/articles/vie...

NF1 is frequently mutated in glioblastoma, yet therapies targeting this alteration often fall short.

Harish N. Vasudevan & team now show NF1 mutant glioblastomas exhibit prognostic signatures with distinct sensitivity to MEK inhibition: insight.jci.org/articles/vie...

ICYMI: Proof-of-concept: A vaccination strategy to prevent coxsackie virus B3–induced development of pancreatic cancer

Pandey et al. vaccinate mice against the common enterovirus CVB3, decreasing infected cells & dramatically reducing abnormal pancreatic areas: insight.jci.org/articles/vie...

Previously shared: A technical advance in the field of organ transplantation!

@tobias-b-huber.bsky.social & team develop a metabolite-enhanced perfusion solution that improves kidney transplant viability, testing it across various species, including humans: insight.jci.org/articles/vie...

How can we study the effects of radiation on immune cells in #cancer?

Using innovative human pancreatic tumor models, @science-wallet.bsky.social and team reveal photon and particle radiotherapy induce signals—grouped as modules—that attract immune cells: insight.jci.org/articles/vie...

🚨 New publication! 🚨In this perspective published in
@insight.jci.org, previous APSA Presidents and Executive Committee members highlight key APSA milestones in strengthening the physician-scientist community, including 20 years of the joint ASCI/AAP/APSA annual meeting!

On a FOX hunt in severe autoimmunity

Jonathan S. Maltzman & team explore the functional interactions among FOXP family members in regulatory T cells, revealing loss of Foxp1 & Foxp4 in Tregs from mice causes systemic inflammation and premature lethality: buff.ly/4kzMQe0

Behind the Scenes: the Khader lab takes a summer outing!

This case series highlights risk factors for infection by a non-tuberculous mycobacterium.

Ananya Gupta @drabhi.bsky.social et al. link GATA2 mutation in the context of immune dysfunction to enhanced susceptibility to M. heamophilum infection in humans: buff.ly/pPIhSlx

JCI Insight - Stimulation of skeletal stem cells in the growth plate promotes linear bone growth Research ArticleBone biologyStem cells Open Access | 10.1172/jci.insight.165226

This research article is climbing to the top with views!

Stimulation of skeletal stem cells in the growth plate promotes linear bone growth by Dana Trompet et al.

buff.ly/bvEZnpb

Proof-of-concept: A vaccination strategy to prevent coxsackie virus B3–induced development of pancreatic cancer

Pandey et al. vaccinate mice against the common enterovirus CVB3, decreasing infected cells & dramatically reducing abnormal pancreatic areas: buff.ly/EV0u2mK

A technical advance in the field of organ transplantation!

@tobias-b-huber.bsky.social & team develop a metabolite-enhanced perfusion solution that improves kidney transplant viability, testing it across various species, including humans:
buff.ly/FyKsRiE

JCI Insight - Virologic characteristics of SARS-CoV-2 infection across evolving omicron subvariants insight.jci.org/articles/vie...

Previously shared: GLP-2 analogs are used for short bowel syndrome.

Kudo et al. studied intestinal tissue from 5 patients throughout a year, finding GLP-2 analogs induce nutrient-absorbing and immune-suppressive cells while also enhancing microbiota diversity: buff.ly/hiG0IDk

ICYMI: 30 years ago, researchers identified polycystin proteins as involved with autosomal dominant polycystic kidney disease.

This issue’s cover features work by Ivana Y. Kuo & team @pkdfoundation.bsky.social on the polycystin complex and its critical role in urine concentration:
buff.ly/aTN2NxA

Irregular heartbeat is a common complication after surgery.

In this research letter, Xander H.T. Wehrens & team reveal a factor derived from atrial fibroblasts—MIF—necessary for atrial macrophage recruitment and post-operative AFib: buff.ly/PL8GnGT

An open letter to the NIH: Value and costs in publishing

Here we share our response to the NIH’s request for information on maximizing research funds by limiting allowable publishing costs: buff.ly/K6hbsA4

#AcademicPublishing #ScholarlyPublishing #OpenAccess
@scholarlykitchen.bsky.social

Acute kidney injury increases the risk for long-term kidney dysfunction

Wen et al. identify urine proteins in pathways of degenerative tubular cell injury, inflammation & fibrosis associated with long-term eGFR decline after hospitalization with AKI: buff.ly/6xqmTk5

GLP-2 analogs are used for short bowel syndrome.

Kudo et al. studied intestinal tissue from 5 patients throughout a year, finding GLP-2 analogs induce nutrient-absorbing and immune-suppressive cells while also enhancing microbiota diversity: buff.ly/hiG0IDk

30 years ago, researchers identified polycystin proteins as involved with autosomal dominant polycystic kidney disease.

This issue’s cover features work by Ivana Y. Kuo & team @pkdfoundation.bsky.social on the polycystin complex and its critical role in urine concentration: buff.ly/aTN2NxA

How well do blood tests reflect the pulmonary microenvironment in post-transplant lung injury?

@mattzinter.bsky.social & team evaluate paired lung and peripheral blood transcriptomes in patients with hematopoietic stem cell transplants.

Full report: buff.ly/IuYJxNr

No bones about it—cellular recycling increases bone formation

Melda Onal & team show mice with increased autophagy in osteoblast lineage cells have enhanced bone mass and strength.

buff.ly/4pcEoLd

ICYMI: A vaccine for Pseudomonas has eluded researchers for decades

@nizet.bsky.social & team now provide a different vaccination approach, demonstrating an engineered nanoparticle vaccine protects mice against lethal pneumonia.

Full report: buff.ly/QgqHe0M