Claudia Guimas Almeida

✨ Highlights:
🔹 BIN1 is enriched at inhibitory synapses
🔹 Loss-of-function (shRNA/LOAD mutants) → loss of inhibitory synapses, hyperactivity
🔹 Effects are independent of Aβ
🔹 Levetiracetam rescues function
#SynapseBiology #Neurodegeneration

Alzheimer’s genetic risk factor Bin1 controls synapse vesicle exo-endocytosis in inhibitory synapses Barata et al. show that the Alzheimer’s risk gene BIN1 is critical for the stability of inhibitory synapses. BIN1 deficiency accelerates the synaptic vesicle endocytic cycle, leading to synapse loss a...

🧠 What if Alzheimer’s risk starts at the synapse?

In our new study led by Mariana Barata, we show that BIN1, a key AD risk gene, regulates inhibitory synapses—loss of BIN1 → hyperexcitability before Aβ.

www.cell.com/cell-reports...

Big news: we are setting up a new non-profit organization to run bioRxiv and medRxiv. It's called openRxiv [no it's not a new preprint server; it's dedicated organization to oversee the servers] openrxiv.org 1/n

Home | Escolho a Europa escolho.eu. Está na hora de escolher a Europa. Está nas nossas mãos fortalecer a economia europeia através das nossas escolhas de consumo.. Neste site, encontra uma série de marcas a evitar e excelent...

Pronto.... já nasceu a criança.

escolho.eu

Participem, colaborem, contribuam :-)

Exclusive: NIH to terminate hundreds of active research grants Studies that touch on LGBT+ health, gender identity and DEI in the biomedical workforce could be terminated, according to documents obtained by Nature.

Sad times for science “For all this talk about free speech, this is direct censorship of scientific research.” www.nature.com/articles/d41...

If you're in the US, considering Europe for your PhD, and you identify as a minority, I will chat with you and review any application documents you need 🧪

Ainda não há resultados dos projectos da FCT, mas alguns cientistas já receberam o “sim” Há quase um ano que os cientistas aguardam pelos resultados das candidaturas ao principal concurso para financiamento de projectos de investigação. Alguns, no entanto, já tiveram resposta.

Há quase um ano que os cientistas aguardam pelos resultados das candidaturas ao principal concurso para financiamento de projectos de investigação. Alguns, no entanto, já tiveram resposta.

Ainda não há resultados dos projectos da FCT, mas alguns cientistas já receberam o “sim” Há quase um ano que os cientistas aguardam pelos resultados das candidaturas ao principal concurso para financiamento de projectos de investigação. Alguns, no entanto, já tiveram resposta.

Obrigada @publico.pt por esta notícia desde Dezembro que os cientistas vivem num estado de ansiedade por causa da FCT, e desde que sairam para alguns a injustiça é imensurável porquê ? www.publico.pt/2025/03/02/c...

Apoio de 20 milhões de euros para contratar cientistas ainda não foi renovado: “Voltamos ao zero” Verba de 20 milhões de euros para apoiar um terço das despesas com a contratação de cientistas foi aprovada em 2024. Instituições de ensino superior mostram-se preocupadas com falta de garantias.

O normal na ciência em Portugal! www.publico.pt/2025/02/13/c...

Concordando com o acesso a todas as publicações científicas não vejo realmente implementar. O guia diz que posso publicar num jornal open access que tem um custo exorbitante apesar de a política de acesso aberto não permitir o pagamento duplo, pela ciência e pela publicação acessoaberto.fct.pt

My NIH study section that was to meet tomorrow was one of those canceled. This represents many months of work by the applicants and by the NIH staff and reviewers. Devastating is the correct word.

Donate to Wikipedia.

Do it today, and every time one of the broligarchs has a tantrum because he can’t buy it

2024 FDA approvals The FDA approved 50 new therapeutics in 2024, with green lights for a novel schizophrenia drug, a first NASH medicine and much more.

'The FDA’s Center for Drug Evaluation and Research approved 50 new small molecules, biologics and oligonucleotide therapeutics last year. The class of 2024 was a little smaller than that of 2023, which had 55 approvals and was the second largest in the past 30 years'
www.nature.com/articles/d41...

"If there is something you can technically do but that won’t answer your question, then don’t do it."
@victora.bsky.social

www.cell.com/news-do/50-i...

Where is the muscle? Arrows 🙏 please

Já começo a duvidar 🤔

Alguém sabe quando saem os resultados dos projetos FCT (PTDC)?
@mcti.bsky.social #FCT

Yes please

Highly-respected non-profit journals like @dev-journal.bsky.social support scientific communities

But after rejection at glam journals, it is tempting to avoid re-review by sliding through commercial ecosystems

BUT WAIT! LOOK! “We will consider papers with reviewer reports from other journals” 😍

Dis you see our last paper in J neurosci? No endosomes only cytoskeleton! It was fun!

Cytoskeleton rules!!!

A panoramic view of cell population dynamics in mammalian aging To elucidate aging-associated cellular population dynamics, we present PanSci, a single-cell transcriptome atlas profiling over 20 million cells from 623 mouse tissues across different life stages, se...

Excited to share our work @science.org. led by our incredible @tommyz626.bsky.social at @rockefelleruniv.bsky.social! By profiling 21 million single cells across life stages, we reveal aging as distinct, development-like transitions, with dramatic cell population changes in specific time windows!

Send me a message for full-text 🙏

The Alzheimer's Disease Risk Gene CD2AP Functions in Dendritic Spines by Remodeling F-Actin CD2-associated protein (CD2AP) was identified as a genetic risk factor for late-onset Alzheimer's disease (LOAD). However, it is unclear how CD2AP contributes to LOAD synaptic dysfunction underlying A...

Yes! Our discovery that CD2AP loss of function might increase the risk of Alzheimer’s by disrupting dendritic spines directly via F-actin regulation and indirectly via beta-amyloid production is on the cover #jneurosci www.jneurosci.org/content/44/4...

Proposta para aumento do orçamento da FCT chumbada no Parlamento O partido Livre tinha apresentado uma proposta para transferir 70 milhões de euros para o orçamento da FCT – colmatando o corte de 68 milhões de euros no Orçamento do Estado.

www.publico.pt/2024/11/27/c...
Apesar do alerta de muitos investigadores com posições de liderança na ciência que se faz neste país o partido socialista absteve-se ao reforço do orçamento que visava não aumentar mas apenas não diminuir face ao ano passado. @ciencia_pt 🧪

Mechanisms of neuronal aging

Virtual I2K Flyer notifying that the Recordings are available on the I2K YouTube channel: https://www.youtube.com/@I2KConference

Happy #MicroscopyMonday!

The recordings of the #Virtual #I2K2024 workshops are available now
tinyurl.com/VirtualI2K20...

Thanks to all who presented!

Please re-share! 2022 and 2023 content available too:
www.youtube.com/@I2KConference

That you need to fly less 🫢

Who should you nominate as reviewers for your manuscript? After a long chat with a post-grad it appears that there's a lot of misguided advice out there. Thread 👇