Dana Davis Phf’nD

White-nose syndrome puzzle solved: Biological mechanisms behind devastating bat disease revealed Millions of bats in North America have died from white-nose syndrome, and a new study from the University of Waterloo explores why and how the fungal disease has devastated bat populations on this…

White-nose syndrome puzzle solved ...

| #WhiteNoseSyndrome | #bats | #fungi | #pathogen | #infection | #Pseudogymnoascus | By @uwaterloo.ca via @sciencex.bsky.social

Homology-mediated transformation of frog-killing fungus Batrachochytrium dendrobatidis illuminates chytrid development and pathogenesis | PNAS The chytrid fungus Batrachochytrium dendrobatidis (Bd) infects amphibians and causes chytridiomycosis, a disease linked to global amphibian decline...

Nice paper on Chytrid genetic tools:

www.pnas.org/doi/10.1073/...

Trump et al realize democrats could use this power against them if they lose the mid-terms or other future elections. This is why you know the plan is to eliminate legitimate elections

I have never shown ID to vote only to register. MN, ME, NJ, AZ

This is my walking the dog podcast

OTR MSH 194 I Thought You Were Dead Podcast Episode · Old Time Radio Mystery, Suspense, & Horror · 12/28/2019 · 56m

Old time radio suspense:

podcasts.apple.com/us/podcast/o...

Figure 1

Long-term behavioral tracking of Paramecium bursaria #micropublication #biology #data #caltechlibrary #Parameciumbursaria #Methods #Methodology https://micropublication.org/journals/biology/micropub-biology-001569

💕 What makes partnerships last?
#Yeast communities exchanging nutrients reveal asymmetric fitness effects determine which species survive. Lysine-dependent strains outlasted adenine-dependent ones
⇒ resource essentiality shapes #evolution

🧬 #YeastResearch #SGD
www.yeastgenome.org/reference/S1...

“At the age of 23, before she'd even earned her PhD, Carol Greider made the discovery that would earn her the 2009 Nobel Prize in Physiology or Medicine.
Along with her supervisor and co-laureate Elizabeth Blackburn, she discovered the enzyme telomerase…”

I was just denied entry to the Dilley detention facility while my constituent, seven-year-old Diana, remains inside.

What kind of sick, horrific conditions are children being forced to endure in there?

I will be back tomorrow. Accountability can’t wait.

Apparently accountability can wait at least 24 hours.

An intracellular meteor shower. EB3 comets tracking growing microtubule plus-ends in a cultured cell.

Diagram of the consumer-resource vaginal microbiota model. The authors track the dynamics of two vaginal microbiota types (CST I and CST IV associated bacteria; C1 and C4) and the shared (Rs) and private resource (Rp) utilised by the two communities. The arrows among compartments represent density-dependent interactions including resource-mediated bacterial growth; lactic-acid-mediated density regulation (self-regulation and antagonism); resource supply; sialic acid cleaving; and background clearance of microbes and resources. The representative species and, or molecules for each model component are listed. The corresponding mathematical model based on ordinary differential equations is detailed in the Methods section of the paper.

The #vaginal #microbiome is shaped by bacterial access to specific nutritional resources. This study uses a resource-based model & clinical data to identify key ecological mechanisms underlying #microbiota composition & potential #BacterialVaginosis interventions @plosbiology.org 🧪 plos.io/3NY2ssu

From the paper: Deeply divergent Treponema pallidum lineage in the Americas and implications for pathogen evolution. We identified and reconstructed a ~5500-year-old 1.7× T. pallidum genome (TE1-3) from a Middle Holocene individual at Tequendama I rock shelter in Colombia. Phylogenomic analysis reveals that TE1-3 is an early-branching sister lineage to all extant T. pallidum subspecies, with divergence dating to ~13,700 years ago (95% HPD: 6768 to 20,592 cal yr B.P.) and coinciding with early human migration and ecological shifts in the Americas. Despite its antiquity, TE1-3 possesses the T. pallidum virulence-associated genes, suggesting conserved pathogenic capacity. TE1-3 provides the earliest molecular evidence of T. pallidum in the Americas to date, bridging a multimillennial gap between skeletal signs and genomic data and offering a rare glimpse into the long-term evolution of treponemal pathogens.

A 5500-year-old Treponema pallidum genome from Sabana de Bogotá, Colombia

"This genome falls outside of known T. pallidum lineages today, but it has many genetic hallmarks associated with virulence in modern pathogens of these subspecies"

Science
pubmed.ncbi.nlm.nih.gov/41570125/

#MicroSky

Top: Subcellular localization of Cap1-GFP in wild-type background (top, tetO-CAP1-GFP/CAP1), Cap1-GFP with C446* (middle, TeO-CAP1C446*-GFP/CAP1) and wild-type Cap1-RFP (bottom, CAP1C446*/TeO-CAP1-RFP) in CAP1/CAP1C446* background. Scale bar, 5 μm. Bottom: Schematic of subcellular localization and transcription activation of CAP1 in wild-type (CAP1/CAP1, left) and CAP1/CAP1C446*. Figure generated with BioRender.

#Azole resistance in #Candida albicans poses a growing threat, and is linked to #StressResponse. @annaselmecki.bsky.social &co show that mutations in the oxidative stress TF Cap1 promote #DrugResistance while exposing a lethal vulnerability at high azole doses @plosbiology.org 🧪 plos.io/4rOrfOz

Top: FK506-resistant strains isolated from the Mucor circinelloides complex. Phenotypic analysis of FK506-resistant isolates in Mucor janssenii CBS185.68 (PS1), Mucor bainieri CBS293.63 (PS3), and Mucor atramentarius CBS202.28 (PS6). WT, wild-type; M, mendelian mutant; E, epimutant. Bottom: Schematic overview of epigenetic silencing contributing to antifungal resistance in Mucor species. fkbA expression enables FKBP12 production and FK506 sensitivity (yeast-like morphology). Epigenetic silencing of fkbA via RNAi and/or heterochromatin leads to FK506 resistance and hyphal growth. Generated with BioRender.com.

#Antifungal resistance is a global threat, but epigenetic mechanisms drive rapid, reversible adaptation in fungi. This study shows that #RNAi or #heterochromatin driven #epimutations transiently silence the gene fkbA to confer FK506 #tacrolimus resistance in #Mucor @plosbiology.org 🧪 plos.io/4qdttWc

At least they are doing something. Impeach Noem, Trump, RFK Jr, etc etc etc. Get some legislation written, let the GOP shoot it down.

Poster for upcoming webinar. Title: Fungal Conservation in the New Year: Species Discovery, Action, Policy, and a Global Strategy. Seven February 2026 11AM PST / 2PM EST / 4PM BRT / 7PM GMT with a registration link. Photos of presenters with talk titles. Huzefa Raja: Discovery is the first step toward conservation: Atromagnispora, a newly identified genus of freshwater ascomycete fungus from Indiana. Kelmer Martins-Cunha: From fungal neglect to action: shifting paradigms in Brazilian conservation. Greg Mueller: Developing A global strategy for fungal conservation. Images of 4 fungi are followed by the text "A webinar presented for Reverse the Red Day" and the logos of Reverse the Red, IIUCN SSC Mushrooms, Brackets, and Puffballs Specialist Group. Global Center for Species Survival at the Indianapolis Zoo. IUCN SSC FUNCC. IUCN SSC Brazil Fungal Specialist Group.

I just saw this and am excited to share!

🍄 Reverse the Red Day 7 Feb.
"Fungal Conservation in the New Year: Species Discovery, Action, Policy, and a Global Strategy"

us02web.zoom.us/webinar/regi...

Bdelloid rotifers are microscopic, all-female aquatic animals that has avoided sex for over 50 million years, they survive by stealing useful genes from other organisms.

…But not when leadership is needed. I recommend you go back to Congress to continue approving completely unqualified Trump appointees and carving back $10 of needed funding from a $20,000 budget cut and acting like you really accomplished something.

My reply to Amy Klobuchar’s ask for money for MN’s next governor:

Please don't run. I have not seen anything from you to suggest you are up to the task to be governor in these difficult times. In the halcyon days of the Obama administration or even Bush I or Il, I could see you being good enough…

I see Amy Klobuchar is officially running for governor. I’d be happy to see other names out there, especially names that haven’t approved every Trump appointee or actually fought against Trump’s antidemocratic and draconian policies.

Researcher Florian Wollweber standing next to a cryo-focused ion beam microscope in a laboratory, with technical infrastructure visible in the background.

The origin of eukaryotic cells continues to be one of the greatest mysteries in biology.

EMBL Grenoble is excited to welcome Florian Wollweber, who will use cutting-edge imaging techniques to study Asgard archaea — microbes closely related to our earliest ancestors. 🦠🔬

www.embl.org/news/people-...

Here with the Lyn Lake sign guy and friends.

second sitting black congressperson to be assaulted in the past week. all the violence seems to be coming from one side, and it ain’t ours

The deadline for the submission of papers to the special issue on the International Yeast Meetings of 2025 has been extended to 31 March. Papers should be connected to one of the meetings listed below. Hurry up and don't miss this chance!

More information at:
onlinelibrary.wiley.com/page/journal...

Alex Pretti’s coworkers take a moment of silence this morning

Image shows a gray-scale image of many circular-shaped yeast cells. There are also many streaks caused by fast-moving cells.

These Brewer's yeast cells were in a hurry!
This was captured with a point-scanning confocal microscope, which scans one point (pixel) at a time, moving from left to right and top to bottom. As a consequence, cells moving faster than the scan speed appear as streaks or exhibit distortions.

Pretty sure your family only finds out you died of cancer if you don’t have insurance. Diagnosis isn’t free.

I was the one you led the ‘moment of rage’ yell. You’d recognize my many layered winter outfit that was similar to everyone else’s