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Diefenbacher Laboratory

@diefenbacherlab.bsky.social

Targeting protein stability in #Cancer via #Ubiquitin-System @HelmholtzMunich @LungHealthMUC and @LMU_Muenchen Impressum: http://www.diefenbacher-lab.com/Impressum/ http://www.diefenbacher-lab.com/ https://www.helmholtz-munich.de/en/environmental-health-ce

692 Followers  |  1,522 Following  |  4 Posts  |  Joined: 25.11.2024  |  1.5043

Latest posts by diefenbacherlab.bsky.social on Bluesky

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Getting ready to kick off our first Bridging Minds in #MunichCancerResearch #Workshop @bmc-lmu.bsky.social #LMU-Munich ! #Cancer is a devastating disease and the #collaboration and #exchange between #clinicians and #scientists is an important first step to lay the foundation for new #therapies.

12.03.2025 08:00 β€” πŸ‘ 11    πŸ” 4    πŸ’¬ 0    πŸ“Œ 0
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Eliminating Aggressive Cancers via PROTAC-like Inducers of Ferroptosis Aggressive and therapy-resistant cancers present a significant challenge to treatment and are associated with poor patients survival. Identifying molecular pathways and compounds that target these pat...

Have a look at this exciting #collaborative #work by Amir Orian, Ashraf Brik Technion Haifa and @diefenbacherlab.bsky.social@www.helmholtz.de on #PROTAC like #degraders to deplete aggressive tumor cells! #ubiquitin and #degradation are indeed #promising #therapeutics www.biorxiv.org/content/10.1...

29.12.2024 15:43 β€” πŸ‘ 10    πŸ” 3    πŸ’¬ 0    πŸ“Œ 0
The 2025 EMBL Annual Poster, listing all of the courses and conferences taking place in 2025 at EMBL

The 2025 EMBL Annual Poster, listing all of the courses and conferences taking place in 2025 at EMBL

Hi Bluesky community! πŸ‘‹

Are you looking forward to 2025 as much as we are? πŸ‘€

We just updated our 2025 Annual Poster to include even more events for you to join, so go and have a look!

➑️ s.embl.org/poster-bl

#EMBLEvents #molecularbiology #lifesciencetraining

13.12.2024 09:06 β€” πŸ‘ 181    πŸ” 122    πŸ’¬ 1    πŸ“Œ 7
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Exciting lecture about #lung #transplant at German Center for Lung Research @bmc-lmu.bsky.social @www.helmholtz.de research institute Lung Health and Immunity in Munich!

05.12.2024 10:09 β€” πŸ‘ 4    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Leveraging Dual-Ligase Recruitment to Enhance Protein Degradation via a Heterotrivalent Proteolysis Targeting Chimera Proteolysis targeting chimera (PROTAC) degraders are typically bifunctional with one E3 ligase ligand connected to one target protein ligand via a linker. While augmented valency has been shown with t...

Leveraging Dual-Ligase Recruitment to Enhance Protein Degradation via a Heterotrivalent Proteolysis Targeting Chimera | Collaboration with @georgwinter.bsky.social and Kristin Riching labs. Now published in Journal of the American Chemical Society @acsjacs.bsky.social pubs.acs.org/doi/10.1021/...

30.11.2024 16:35 β€” πŸ‘ 55    πŸ” 13    πŸ’¬ 2    πŸ“Œ 1

Promoting a positive research culture is so important to support each other - and to ultimately enable great science!

@colemanlab.bsky.social has put together an array of scientists who are striving for this in many different ways ‡️

#research #culture πŸ§ͺ

30.11.2024 13:06 β€” πŸ‘ 131    πŸ” 30    πŸ’¬ 14    πŸ“Œ 1

We have an open #PhD #studentship as part of our "Black Leaders in Cancer" programme at @crukconvergence.bsky.social & @icrlondon.bsky.social. About computational modelling of T-cell evolution in cancer. www.findaphd.com/phds/project... I'm looking forward to meeting prospective students #CRUKfunded

28.11.2024 09:40 β€” πŸ‘ 32    πŸ” 28    πŸ’¬ 0    πŸ“Œ 1
Attending the annual German Centres for Lung Research meeting with a focus on @cancer #frombenchtobed in Bad Nauheim. Exciting talks about ongoing clinical trials and screening efforts in Germany. Will follow up with a talk about our research on ubiquitin signalling in @lungcancer tomorrow!

Attending the annual German Centres for Lung Research meeting with a focus on @cancer #frombenchtobed in Bad Nauheim. Exciting talks about ongoing clinical trials and screening efforts in Germany. Will follow up with a talk about our research on ubiquitin signalling in @lungcancer tomorrow!

28.11.2024 12:35 β€” πŸ‘ 3    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Dynamic regulation of the oxidative stress response by the E3 ligase TRIP12 The oxidative stress response is centered on the transcription factor NRF2 and protects cells from reactive oxygen species (ROS). While ROS inhibit the E3 ligase CUL3-KEAP1 to stabilize NRF2 and elici...

Excited to report our discovery of an important component of the oxidative stress response: the E3 ligase TRIP12. It acts as a chain elongation factor that amplifies CUL3-KEAP1 activity to drive NRF2 degradation as cells recover from stress.

www.biorxiv.org/content/10.1...

26.11.2024 14:53 β€” πŸ‘ 73    πŸ” 25    πŸ’¬ 5    πŸ“Œ 0

Welcome to the Tumor Macroenvironment (yes, that's an "a", not a typo). I hope this is helpful for those interested in cancer as a systemic disease. So much to learn!

go.bsky.app/RQuYfnK

26.11.2024 17:33 β€” πŸ‘ 29    πŸ” 7    πŸ’¬ 9    πŸ“Œ 0

New week, updated starter pack. Now with 69 profiles to follow if you are interested in anything #ubiquitin or #Ubl: signalling, structure and biochemistry, biology, mechanisms, proteostasis, TPD, chemical biology, etc. Let me know if you or anyone else is missing.

25.11.2024 08:32 β€” πŸ‘ 21    πŸ” 15    πŸ’¬ 4    πŸ“Œ 1

Check out this list of ubiquitin and Ubl profiles to follow. Repost if you want me to add you to it. Let’s create a good community here ☁️ go.bsky.app/3VPQofn

15.11.2024 19:38 β€” πŸ‘ 49    πŸ” 48    πŸ’¬ 6    πŸ“Œ 1

@diefenbacherlab is following 19 prominent accounts