Chase Bolt

‘Chinese Peptides’ Are the Latest Biohacking Trend in the Tech World

"Biopharma people are shockingly the most reserved"

Shockingly, the people that know the most about the dangers of injecting random shit into your body are most averse to injecting random shit in your body.

weather forecast for freezing fog tonight.

What America Might Look Like With Zero Immigration

I hope all the boomers that voted for Trump enjoy getting their medical care from robots in their sunset years.

I want to thank all of the people that said that Trump wouldn't be as bad as Kamala.

I haven’t been in the field for a few years but all of the major claims made in the abstract have been demonstrated before. But I haven’t read past the abstract so they may explain in better detail why their findings are new

They said there would be wind. I came for the wind.

synthetic organisms will give good instruction on what is needed to build it.

novel ideas on how evolution of species can happen

new databases holding compendia of molecular interactions. scored, annotated and modeled, with convenient links to vendors for synthesis.

#biotech #AI

Evo: DNA foundation modeling from molecular to genome scale | Arc Institute Introducing Evo, a biological foundation model that generalizes across the fundamental languages of biology: DNA, RNA and proteins. Evo is capable of both prediction tasks, and generative design from ...

This is the kind of thing that makes me want to go back to academia. The future of experiments is incredible. Just some ideas:

#biotech #AI

Ultimately, will people tolerate being given a diagnosis by an AI?

I'm not sure.

#ai-future

Fuck. He is back. Cruising. #halloween

There are a bunch of kids going down the street trick or treating and a car went past real slow blaring the Halloween theme song. It was fucking awesome. 🎃👻

Amazon/MGM removes all guns from James Bond digital posters on Prime 007 is without his Walther PPK on the latest digital posters featured on Prime Video for the James Bond series.

The enshitification continues. I'm not even a Conservative, I just think it is fucking stupid to remove a gun from a picture when the 27 movies are just two hours of guns. There is a person in this world that gets paid - probably a shit ton of money - to make these meaningless decisions.

Craft Breweries Struggle as Sales and Appetites Wane

Here is a clue, make anything other than a fucking IPA.

Thank you Marian!

There is only #babyshark

Thanks Olga!

Thanks Dario!

Yes they do!

Thank you Neil!

Co-option of an ancestral cloacal regulatory landscape during digit evolution - Nature The regulatory landscape controlling Hoxd gene expression in tetrapod digit development was probably co-opted from a pre-existing cloacal regulatory mechanism, as evidenced by the effects of gene...

Link to the original work (dummy).
www.nature.com/articles/s41...

How Did Hands Evolve? The Answer Is Behind You.

Our work exploring a new explanation for the regulation of Hoxd genes and the #fin-to-limb transition. 🧪

It was an absolute joy working on this w/ @aurhin.bsky.social and @homeobox.bsky.social @denisduboule.bsky.social @neilshubin.bsky.social

#evo-devo #InHoxWeTrust

The precarious future of consumer genetic privacy Congress and other lawmakers must act to robustly protect direct-to-consumer genetic data and biospecimens into the future

There is a lot of concern about leaked genetic data, but what I wonder is, can a "reputable" legal entity like a health insurance company use this information? Or the government? Wouldn't the chain of custody be unreliable? #genetic #privacy

sequence that dude

Merry Crispus!

Join this year's CSH Asia Systems Biology of Gene Regulation & Genome Editing meeting in beautiful Suzhou, China, Oct 20-24. Let's bring the international communities together! Abstract deadline Sept 19! Infos and registration at csh-asia.org?content/2767. Please repost!

The end of the genetic paradigm of cancer Genome sequencing results and single-cell transcriptomics continue to produce findings that challenge the idea that cancer is purely a ‘genetic disease’. This Essay delves into cancer omics data that ...

"the quest for drug targets have meanwhile reduced much of cancer research from a scholarly biological discipline to a transactional operation concerned more with cataloguing molecular alterations and finding associations, than with understanding fundamental principles using formal theory." Agreed.

Conservative influencer Charlie Kirk shot dead at Utah event Kirk, an activist and the founder of conservative student group Turning Point USA, played a key role in driving youth support for Trump in November.

Charlie Kirk is dead by assassination. This political violence needs to stop. Things will only continue to get worse. I didn't like him but no one should be killed for their beliefs and speaking them aloud.

Drivers recruit pioneer factors that then "hop" to near-3D contacts to spread active chromatin context, producing a stable active landscape.

Enhancers mediate euchromatin hopping at chromatin contact points Enhancer-mediated gene activation involves the recruitment of chromatin modifiers and RNA polymerase to target promoters, but it is unknown if enhancers influence chromatin beyond their target genes. ...

Euchromatin hopping explains how some enhancers seem to initiate the formation of active regulatory landscapes, and why some/many enhancer deletions don't affect transcription quantity; there are driver and passenger enhancers.
#chromatin #enhancers #generegulation