@PhysGenCenter

Friday Feb. 27 at 12pm CT, Prof. Steve Henikoff presents the Monthly Seminar on Physical Genomics: "Histone Overexpression In Cancer" live on Zoom!

Registration is free at tinyurl.com/2rw8n7bt

#northwestern #cancer #genomics #research #chromatin #dna #science #biology #cpge #fredhutch #research

Hacking Cancer’s Survival Code Northwestern professor Vadim Backman, who teaches in the McCormick School of Engineering and the Feinberg School of Medicine, is director of the University’s Center for Physical Genomics and Engineeri...

“We did not set out to directly kill cancer cells. We wanted to take away their superpower — their inherent ability to adapt, to change and to evade.”

CPGE's latest cancer research featured in Northwestern Magazine

#cancer #chromatin #genomics #cpge

magazine.northwestern.edu/discovery/va...

New preprint from the Hernando lab!
www.biorxiv.org/content/10.6...

Combining 3D genome profiling and high resolution imaging we demonstrate how chromatin architecture cooperate with mechanical confinement in conferring melanoma mesenchymal cells high migratory capacities.

YouTube video by Center for Physical Genomics and Engineering Taekjip Ha- DNA Mechanics And Nucleosome Condensability As Biophysical Backdrop Of Genome Functions

Now on YouTube! Prof. Taekjip Ha's fantastic recent seminar at CPGE, "DNA Mechanics And Nucleosome Condensability As Biophysical Backdrop Of Genome Functions"

#biophysics #chromatin #dna #northwestern #epigenetics #genomics #genome #science #harvard #CPGE

youtu.be/G4I2dKr-dVE

Today at 12pm CT! The Monthly Seminar on Physical Genomics featuring Taekjip Ha, PhD of Harvard Medical School: "DNA Mechanics And Nucleosome Condensability As Biophysical Backdrop Of Genome Functions"

Register for free at: tinyurl.com/3zhzu57j

#genomics #chromatin #dna #biophysics #biology

Tomorrow at 12pm CT! The Monthly Seminar on Physical Genomics featuring Taekjip Ha, PhD of Harvard Medical School: "DNA Mechanics And Nucleosome Condensability As Biophysical Backdrop Of Genome Functions"

Register for free at: tinyurl.com/3zhzu57j

#genomics #chromatin #dna #biophysics #biology

Join us Friday, Jan. 30 at 12pm CT for the Monthly Seminar on Physical Genomics featuring Taekjip Ha, PhD of Harvard Medical School: "DNA Mechanics And Nucleosome Condensability As Biophysical Backdrop Of Genome Functions"

Register for free at: tinyurl.com/3zhzu57j

#genomics #chromatin #dna #gene

YouTube video by Center for Physical Genomics and Engineering Chromatin Folding And Gene Activation: From The Nucleosome To Transcription Hubs

Today's fantastic seminar by Prof. Wendy Bickmore, "Chromatin Folding And Gene Activation: From The Nucleosome To Transcription Hubs", can now be viewed on the CPGE YouTube channel at youtu.be/6KLj9ThLL_U

#chromatin #genomics #transcription #northwestern #cpge #dna #epigenetics #science #research

Today at 12pm CT, Wendy Bickmore, PhD presents the Monthly Seminar on Physical Genomics live on Zoom:

"Chromatin Folding And Gene Activation: From The Nucleosome To Transcription Hubs"

Registration is free. Join us!

tinyurl.com/f9njvnyu

#chromatin #genomics #genes #biology #dna #transcription

Friday, Nov. 21 @ 12pm CT, Wendy Bickmore, PhD presents the Monthly Seminar on Physical Genomics live on Zoom: "Chromatin Folding And Gene Activation: From The Nucleosome To Transcription Hubs"

Registration is free. Join us!

tinyurl.com/f9njvnyu

#chromatin #genomics #northwestern #biology #dna

Friday, Nov. 21 @ 12pm CT, Wendy Bickmore, PhD presents the Monthly Seminar on Physical Genomics live on Zoom: "Chromatin Folding And Gene Activation: From The Nucleosome To Transcription Hubs"

Registration is free. Join us!

tinyurl.com/f9njvnyu

#chromatin #genomics #northwestern #biology #dna

Life Is Geometry In 2025, we’ve got DNA all figured out, right? It’s been over fifty years since Crick and Watson (and Franklin) discovered the double helix…

Think we've got DNA all figured out? Nope. Researchers at Northwestern University say our genome has a geometric code, and we may be "living, breathing computational systems." 😲

H/T @kylemacquarrie.bsky.social @physgencenter.bsky.social @nuintmed.bsky.social

kimbellard.medium.com/life-is-geom...

From Sequence to Shape: Scientists Discover the Possible Geometric Blueprint of Complex Life New research from Professors Vadim Backman and Igal Szleifer reveals the language that stores cell memory -- written in the shape of the genome itself.

New CPGE research in Advanced Science describes a language hidden in the genome, beyond the DNA sequence. The geometric code may help cells “remember” how to create and preserve memories, functioning like a network of living computers.

#chromatin #dna

www.mccormick.northwestern.edu/news/article...

This Friday @ 12pm CT, Prof. Anja Groth of the University of Copenhagen presents the Monthly Seminar on Physical Genomics: "Epigenetic Cell Memory - How Cells Copy Their Epigenome", live on Zoom!

Registration is free at tinyurl.com/5t59y8kj

#northwestern #chromatin #genomics #biology #dna #bio

Friday Sept. 26 @ 12pm CT Prof. Anja Groth of the University of Copenhagen presents the Monthly Seminar on Physical Genomics: "Epigenetic Cell Memory - How Cells Copy Their Epigenome", live on Zoom!

Registration is free at tinyurl.com/5t59y8kj

#northwestern #chromatin #genomics #biology #dna #bio

YouTube video by Center for Physical Genomics and Engineering Travis Craddock, PhD: Quantum Spin Dynamics in Biology

The fascinating August Seminar on Physical Genomics by Travis Craddock, PhD can now be watched on YouTube: "Quantum Spin Dynamics in Biology: Weak Magnetic Field and Isotope Effects from Microtubules to Genome Regulation"

#quantum #biophysics #chromatin #genomics #biology #dna

youtu.be/ZA2j_0PqPXQ

Coming up at 12pm CT today! Travis Craddock gives the Monthly Seminar on Physical Genomics live on Zoom: "Quantum Spin Dynamics in Biology: Weak Magnetic Field and Isotope Effects from Microtubules to Genome Regulation"

Free registration at: tinyurl.com/3mhyseyr

#quantum #biology #chromatin #dna

This Friday August 29 @ 12pm CT! Travis Craddock presents the Monthly Seminar on Physical Genomics live on Zoom: "Quantum Spin Dynamics in Biology: Weak Magnetic Field and Isotope Effects from Microtubules to Genome Regulation"

Registration is free at: tinyurl.com/3mhyseyr

#chromatin #dna #quantum

Friday August 29 @ 12pm CT, Travis Craddock presents the Monthly Seminar on Physical Genomics live on Zoom: "Quantum Spin Dynamics in Biology: Weak Magnetic Field and Isotope Effects from Microtubules to Genome Regulation"

Registration is free at: tinyurl.com/3mhyseyr

#chromatin #dna #quantum

YouTube video by Center for Physical Genomics and Engineering 2025 Physical Genomics Training Program Research Showcase

The 2025 Physical Genomics Training Program Research Showcase is now on YouTube! Check out 3 short talks by outstanding program participants and learn about the cutting-edge convergent science happening at CPGE.

#cpge #chromatin #biophysics #AI #cancer #nih #genomics

youtu.be/JTCXlXA8D4M?...

Coming up at 12pm CT today, the Physical Genomics Training Program Research Showcase live on Zoom! Three of our PhD trainees will discuss their exciting research projects - join us and experience the breakthrough science happening at CPGE!

Registration is free at: tinyurl.com/yj5v8y85

CPGE in Northwestern News: New strategy doubles chemo effectiveness in treatment-resistant cancer: restoring cellular memory prevents cancer cells’ ability to adapt to evade treatment

#cancer #chemo #chromatin #chemotherapy #northwestern #genomics

news.northwestern.edu/stories/2025...

Leveraging chromatin packing domains to target chemoevasion in vivo | PNAS Cancer cells exhibit a remarkable resilience to cytotoxic stress, often adapting through transcriptional changes linked to alterations in chromatin...

New CPGE research out today in PNAS: "Leveraging chromatin packing domains to target chemoevasion in vivo"

On the role of chromatin in cellular adaptation to cytotoxic stress, and a framework for enhancing cancer therapies with broad potential across multiple cancers.

www.pnas.org/doi/10.1073/...

The Physical Genomics Training Program Research Showcase is going live on Zoom this Friday, July 25 at 12pm CT. Three of our PhD trainees will discuss their exciting research projects - join us and experience the breakthrough science happening at CPGE!

Registration is free at: tinyurl.com/yj5v8y85

Join us live on Zoom Friday, July 25 at 12pm CT for the Physical Genomics Training Program Research Showcase! Three of our PhD trainees will discuss their research projects and the exciting convergent science happening at CPGE

Registration is free at: tinyurl.com/yj5v8y85

#chromatin #genomics

Microtopography-induced changes in cell nucleus morphology enhance bone regeneration by modulating the cellular secretome - Nature Communications Nuclear morphology plays a critical role in regulating gene expression and cell function. Here, Wang et al. report that topography-induced nuclear deformation enhances the secretome of hMSCs, promotin...

Collaborative research between CPGE and the Center for Advanced Regenerative Engineering at Northwestern published in Nature Communications: "Microtopography-induced changes in cell nucleus morphology enhance bone regeneration by modulating the cellular secretome"

www.nature.com/articles/s41...

Multiplexed Chromatin Analysis Using Optical Spectroscopic Statistical Nanosensing In single cells, chromatin packs into organized structures to perform biological functions, such as RNA transcription regulation. Characterizing such structural behaviors, including packing density an...

New CPGE research published in ACS Photonics: "Multiplexed Chromatin Analysis Using Optical Spectroscopic Statistical Nanosensing", highlighting the capacity of PWS microscopy to sense chromatin ultrastructure

#chromatin #imaging #northwestern #genomics #photonics

pubs.acs.org/doi/full/10....

YouTube video by Center for Physical Genomics and Engineering Xi (Dawn) Chen - Computational Enhanced Multicontrast Imaging of Organoids and In Vivo Mouse Brain

Prof. Dawn Chen's lecture for the June Seminar on Physical Genomics, "Computational Enhanced Multicontrast Imaging of Organoids and In Vivo Mouse Brain", can now be viewed at CPGE's YouTube channel:

youtu.be/BqhpxuoQevw

#microscopy #biology #AI #northwestern #biophotonics #cpge

From structure to function: Unpacking how genome organization shapes cell behavior

CPGE's research has been featured by the National Science Foundation's "Science Matters" series - give it a read!

#genomics #cpge #dna #biophysics #chromatin #microscopy

www.nsf.gov/science-matt...

Today at 12 noon CT, Dawn Chen, PhD presents the Monthly Seminar on Physical Genomics: Computational Enhanced Multicontrast Imaging of Organoids and In Vivo Mouse Brain

Live on Zoom, register at tinyurl.com/mr2smffd

#imaging #northwestern #biology #AI #microscopy