Kevin Outterson

This time with #AMR

New funding opportunity opened today for Gram-negative antibacterial discovery (as late as LO) in therapeutics! gcgh.grandchallenges.org/challenge/in...

Welcome

Why destroy cancer research and cede global scientific leadership to China?

It is not clear how Harvard Law Review peer reviews student notes.

There might be many good reasons to strengthen such inspections, but is zoonotic transmission in USA a top tier risk that should be prioritized now? I’d like to hear from experts on this.

This law student note presumes that important zoonotic jumps from animals to humans occur in the USA, leading to a recommendation to more tightly regulate live animal importation. For most salient examples, such as COVID and HIV/AIDS, zoonotic transmission was outside the USA.

Charting the Path to Tackle AMR: How to Create an Inclusive and Impactful Independent Panel In 2021 alone, AMR killed an estimated 1.14 million people annually—and if countries stick to a business-as-usual approach, it could claim 39 million lives between 2025 and 2050. Beyond the human toll...

Which lessons can be learned from prior international science panels? How can this help the new Independent Panel on Evidence for Action on AMR? www.cgdev.org/blog/chartin...

Great morning session on innovation here at this session led by Prof Sam Kariuki, KEMRI

Now Mingyuan Zhang on the Chinese role in the global antibiotic supply chain, with clever use of antidumping data and trade fairs in her anthropological work.

Next up was Mirza A Portillo, UC Dublin, on some unintended consequences of antibiotic narratives

@chddd.bsky.social Univ Vienna, spoke today at the British Academy on his research on the antibiotic pipeline, proposes a new triad of how we could think about success.

Great morning session on innovation here at this session led by Prof Sam Kariuki, KEMRI

Now Mingyuan Zhang on the Chinese role in the global antibiotic supply chain, with clever use of antidumping data and trade fairs in her anthropological work.

Next up was Mirza A Portillo, UC Dublin, on some unintended consequences of antibiotic narratives

@chddd.bsky.social Univ Vienna, spoke today at the British Academy on his research on the antibiotic pipeline, proposes a new triad of how we could think about success.

Dr Sonia Lewycka on equity discourse in AMR. Most AMR deaths are in lower income settings, so solutions must center equity. (Un)intended Consequences conf @ British Academy.

Nice way to transform Reviewer 2 comments into a paper!

The most amazingly painful episode of family holidays!

I also have concerns about the equities of this system

Academic Twitter found a new home. More Bluetorials, please. Any regrets from how the tenure system operates?

Do we have an AMR group?

Access to essential medicines is not improving over the past 4 decades with existing tools.

"The gap between richer (high- and upper-middle-income) and poorer (lower-middle- and low-income) countries remained largely unchanged over time."

www.healthaffairs.org/doi/epdf/10....

Most cervical cancer deaths are in lower-income settings worldwide; rollout of the vaccines there has been painfully slower than high-income countries. Bring this good thing to more people.

Trends in infection incidence and antimicrobial resistance in the US Veterans Affairs Healthcare System: a nationwide retrospective cohort study (2007–22) Significant reductions in methicillin resistance in S aureus, vancomycin-resistant E faecium, and fluoroquinolone resistance across multiple pathogens suggest that control efforts have had an effect on resistance. The rise in extended-spectrum β-lactamases-producing Enterobacterales and recent surge in hospital-associated infections emphasise the need for ongoing surveillance and interventions. Our study highlights how coupling the analysis of phenotypic incidence with resistance proportion can enhance interpretation of antimicrobial resistance data.

15 years data on infections from the US VA: www.thelancet.com/journals/lan...

My 3 takeaways: (1) Infection prevention and control works; (2) We still need better antibiotics; and (3) the choice of the denominator in such studies should be carefully made
www.thelancet.com/journals/lan...

Modern Warfare Is Breeding Deadly Superbugs. Why? Researchers are trying to understand why resistant pathogens are so prevalent in the war-torn nations of the Middle East.

Bacteria adapt to take advantage of human weaknesses and situations, including war. We should not be surprised that the bacteria rule the battlefield. www.nytimes.com/2024/11/26/m...

Research is of limited use unless communicated - thanks for this 1 pager

Using the best available data to estimate the cost of antimicrobial resistance: a systematic review - Antimicrobial Resistance & Infection Control Background Valuation of the economic cost of antimicrobial resistance (AMR) is important for decision making and should be estimated accurately. Highly variable or erroneous estimates may alarm policy...

Analysis like this systematic review from 5 years ago is needed to move AMR policy forward in the era of an Independent Panel on Evidence For Action on AMR. #IPEA-AMR Here, a careful critique of methodology choices in studies reporting the economic costs of AMR. link.springer.com/article/10.1...

Azithromycin to Reduce Mortality | NEJM To the Editor: The AVENIR (Azithromycine pour la Vie des Enfants au Niger: Implementation et Recherche) trial reported by O’Brien et al. (Aug. 22/29 issue)1 shows the mortality benefit of mass dist...

The ethical imperative is to save lives now, with these decisions left in the hands of those most directly at risk. Our letter (with Maple Goh & Aaron Kesselheim) published in NEJM www.nejm.org/doi/full/10....

But when data demonstrates a large mortality benefit in a low-income country (Niger) from mass administration of azithromycin to children under 5, some barriers are raised based on the impact on future resistance.