Melanie Lemaire

Cell-free placental DNA: What do we really know? Author summary Cell-free DNA are fragments of free-floating DNA released by cells into blood circulation. During pregnancy, the placenta releases cell-free placental DNA (cfpDNA) into maternal blood c...

Congratulations to my lab mates for a phenomenal paper from @samanthalwilson.bsky.social lab: journals.plos.org/plosgenetics...

Overall, we show that #placental #epigenetics may further our understanding of the association between #IVF and negative pregnancy outcomes, and that sex-specific differences in #DNAmethylation and cell composition should be considered when analyzing placental data.

We estimated #placental cell composition for each sample using cell type specific #DNAmethylation patterns, and found that there were differences between fetal sex and between conception type in main placental cell type proportions.

Using public #DNAmethylation data from #NCBI Gene Expression Omnibus (GEO), we found that #IVF placentas have different DNA methylation patterns compared to spontaneously conceived placentas. 🧬

Very excited to share the results from our latest Meta-analysis at the Wilson Pregnancy Lab examining #placental DNA methylation in #IVF pregnancies doi.org/10.1093/mole...

@smithk63.bsky.social @samanthalwilson.bsky.social
@oxfordacademic.bsky.social