Catarina Marques

Save the dates!! @bspparasitology.bsky.social Spring Meeting 2026 will be in Bonnie Glasgow! 7-9 April 2026, with a drinks reception in Glasgow City Chambers on the 6th of April 2026!
Keep an eye on the BSP website for registration and abstract submission!
Logo by @shannaraeilean.bsky.social! 🦟

11.09.2025 11:09 — 👍 31    🔁 21    💬 1    📌 2

Pleased 2 share our new article: single-molecule replication mapping in Leishmania using DNAscent.
We show widespread stochastic origin firing and insights into genome variability.

www.cell.com/cell-reports...

06.08.2025 08:20 — 👍 19    🔁 7    💬 1    📌 0

Specialised RNA decay fine-tunes monogenic antigen expression in African trypanosomes Antigenic variation is a sophisticated immune evasion strategy employed by many pathogens. Trypanosoma brucei expresses a single Variant-Surface-Glycoprotein (VSG) from a large genetic repertoire, whi...

So happy to share the first preprint from our lab on post-transcriptional regulation at the VSG expression-site body in trypanosomes. @ybri-uoy.bsky.social @york.ac.uk

27.05.2025 10:28 — 👍 32    🔁 12    💬 2    📌 1

Nanopore sequencing reveals that DNA replication compartmentalisation dictates genome stability and instability in Trypanosoma brucei - Nature Communications A full description of trypanosome genome replication has proved elusive. Here, after genome assembly, the authors reveal compartmentalisation of DNA replication activity and stability between transcri...

DNA replication beyond the cores of megabase chromosomes of T. brucei -- some of my PhD work is FINALLY out! doi.org/10.1038/s414... thank you to @rmc9z.bsky.social @marquescata.bsky.social Emma, Dario, Kathryn, Graham and Craig!

17.01.2025 06:29 — 👍 14    🔁 6    💬 2    📌 1

Nanopore sequencing reveals that DNA replication compartmentalisation dictates genome stability and instability in Trypanosoma brucei - Nature Communications A full description of trypanosome genome replication has proved elusive. Here, after genome assembly, the authors reveal compartmentalisation of DNA replication activity and stability between transcri...

New paper @uofgsii.bsky.social led by @scotomorph.bsky.social @marquescata.bsky.social where we show that T. brucei DNA replication dynamics reflect structural and functional compartmentalisation of the genome, including stability. Well done Marija, and thanks all co-authors!
doi.org/10.1038/s414...

17.01.2025 09:48 — 👍 28    🔁 8    💬 1    📌 1

I’m still getting to grips with this so apologies!

18.11.2024 14:12 — 👍 0    🔁 0    💬 1    📌 0

Nuclear DNA replication in Leishmania major relies on a single constitutive origin per chromosome supplemented by thousands of stochastic initiation events Understanding genome duplication requires characterisation of the locations where DNA replication initiates, termed origins. Genome-wide mapping of DNA replication origins has mainly been derived from...

New preprint from others in the lab - Mapping origins of DNA replication in Leishmania.
Great work Jeziel, Gabriel, @marquescata.bsky.social, Marija, Craig, Dario and the boss!
www.biorxiv.org/content/10.1...

18.11.2024 10:00 — 👍 16    🔁 8    💬 1    📌 0

Extremely excited to meet former colleagues from my PhD, other BoP 2019 @mblscience.bsky.social alumni, old friends and colleagues, as well as many new!

06.11.2024 21:28 — 👍 9    🔁 3    💬 0    📌 1

No, and out of curiosity, how would you know?

21.10.2024 10:04 — 👍 1    🔁 0    💬 0    📌 0