@urialonlab.bsky.social
The Alon lab explores design principles of biological circuits, focusing on systems medicine, aging, and healthspan.
Apple podcasts: podcasts.apple.com/us/podcast/%...
Spotify: open.spotify.com/show/78Ubzk0...
Why does innovative research necessitate a jump into the unknown? Find out (and much more) in episode 147 of רעב לידע עם אור דניאל (Hungry for Knowledge with Or Daniel)!
www.learntech.co.il/podcast/pod1...
It struck me that I spent 25 years building and nurturing this group, longer than my marriage or children, which has great power and meaning. (2/2)
23.04.2025 12:07 — 👍 3 🔁 0 💬 0 📌 0
Sweet moment in life, our 25th lab anniversary. In a circle, we looked at each other, a group of people with shared values and a soft approach, who want each other to succeed and be happy. (1/2)
23.04.2025 12:07 — 👍 20 🔁 1 💬 1 📌 2
Masterpiece by a masterful scientist
Natural Neuroscience by Nachum Ulanovsky
@mitpress.bsky.social mitpress.mit.edu/978026204499...
Our latest on aging, where we reveal an unexpected link between healthspan and equality of lifespans.
By @y1fanyang.bsky.social , out now @naturecomms.bsky.social
www.nature.com/articles/s41...
Now in French and Spanish - our pregnancy paper is highlighted also in @lefigaro.fr and @elpais.com
sante.lefigaro.fr/medecine/com...
elpais.com/salud-y-bien...
Amazing clinical epidemiology! The power of numbers! @urialonlab.bsky.social
www.nature.com/articles/d41...
We now have our most detailed picture yet of how pregnancy affects the body on a weekly basis from 20 weeks pre-conception to 1.5 years after delivery. Fab work from @urialonlab.bsky.social
Read @newscientist.com.
www.newscientist.com/article/2473...
"Pregnancy’s true toll on the body: huge birth study paints most detailed picture yet"
Our study highlighted in @nature.com News
www.nature.com/articles/d41...
Work by Dr. Alon bar, Ron Moran. With Netta Mendelson Cohen, Avi Mayo, Yael Korem-Kohanim, Yoel Toledano, Clalit Healthcare.
Read the complete story here:
www.science.org/doi/10.1126/...
Pregnancy is a dynamic process, stretching physiological control to the extreme with lasting postpartum effects.
We now have a deeper understanding of physiological adaptation.
In pregnancies with complications (pre-eclampsia, gestational diabetes, postpartum hemorrhage),
distinct deviations from healthy profiles were evident. Gestational diabetes, in particular, showed marked changes, mostly in the pre-conception period.
The study also spans 20 weeks pre-conception, where we see changes in folic acid, CRP, and albumin levels.
These hint lifestyle changes such as a healthier diet and taking recommended supplements, supporting healthy fetal development.
Nearly half of the lab tests take many months (and in some cases up to a year) to settle after delivery,
highlighting what a journey pregnancy is, even after delivery.
Lab tests can be clustered into stereotypical profiles, implying global control principles governing physiological adaptations in pregnancy.
We see strong undershoots and overshoots in many lab tests at delivery, indicating strong compensation mechanisms in action during pregnancy.
Excited to share our new study revealing the intricate dynamics of pregnancy & postpartum physiology! We analyzed 40M lab tests from 300K pregnancies and 160K women (cross-sectional) and mapped week-by-week changes starting from preconception to months-long postpartum recovery.
27.03.2025 12:44 — 👍 14 🔁 7 💬 1 📌 1
Harnessing huge data from pregnancy natural experiments @urialonlab.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Theory predicted two kinds of fibrosis, hot and cold.
We show in vivo that hot and cold fibrosis describe heart failure, and heart attack, respectively, showing that they are very different disease states. @shovalmiyara.bsky.social @eldadtzahor.bsky.social
Sagol lecture in longevity research - Myriam Grunewald on vasculature maintenance for longevity
18.03.2025 09:12 — 👍 3 🔁 0 💬 1 📌 0
Join us at the ICSB in Dublin this October - I will chair the session on aging systems biology
icsb2025.com
It’s finally here! My PhD work, five years in the making, is now published @CellSystems @cellpress.bsky.social 🚨
Cold and hot fibrosis define clinically distinct cardiac pathologies. www.cell.com/cell-systems...
My brilliant PhD student @Yaelebel.bsky.social gave a talk at the Azrieli Graduate Students forum about her research on using excitable dynamics to explain pulsatile immune phenomena, and how research questions can come from the most unexpected places. Well done Yael!
youtu.be/MdwqWx5emo4
Will be attending the Quantitative Immunology workshop at the Princeton Center for Theoretical Science later month.
pcts.princeton.edu/events/2025/...
and found that only targeting CRH can bypass this adaptation and effectively lower cortisol. (2/2)
Work by @tomermilo.bsky.social
www.embopress.org/doi/full/10....
Why do cortisol-lowering drugs work for Cushing’s but fail in mood disorders & chronic stress?
We propose that the ability of the pituitary and adrenal glands to adjust their functional masses—normally beneficial—counteracts the drug’s effect. Using a math. model, we screened HPA interventions (1/2)
@urialonlab.bsky.social lab reveals a hormone circuit that explains why most HPA drugs fail for mood disorders and predicts the few that work ➡️ www.embopress.org/doi/full/10....
04.02.2025 14:20 — 👍 8 🔁 5 💬 0 📌 0Really enjoying Uri Alon’s characteristically wonderful lectures on aging:
www.weizmann.ac.il/mcb/alon/cou...
Videos and lecture notes from my latest course, Systems Aging, are available now at:
www.weizmann.ac.il/mcb/alon/cou...
Invitation poster to the Global Gerophysics conference
Excited to speak at the Global Conference on Gerophysics, where we'll explore how physics can revolutionize our understanding of aging and mortality. Join us and get 10% off registration with code GCGP10.
See you there, and sign up here: medicine.nus.edu.sg/trp/healthy-...
