NCCR RNA & Disease

Preprint by the Grosshans lab w/ co-1st authors Dimos Gaidatzis, Maike Graf-Landua & Stephen P. Methot "A scheduler for rhythmic gene expression" @biorxivpreprint.bsky.social
doi.org/10.1101/2025...
@labgrosshans.bsky.social
@smethot.bsky.social
@fmiscience.bsky.social

 📅 Program of the NCCR RNA & Disease Seminar Series for the Autumn Semester 25/26:
For more information visit: nccr-rna-and-disease.ch/news/article...

@unibe.ch @ethz.ch @snf-fns.ch

Protocol for monitoring mRNA translation and degradation in human cell-free lysates Cell-free translation is a powerful tool for studying protein synthesis. Here, we present a protocol for monitoring mRNA translation and degradation u…

*️⃣ Step-by-step STAR protocol for Cell-free translation and mRNA decay *️⃣
What to do (and what not to do 😅) guide based on our work on Nsp1 published in @cp-cellreports.bsky.social.
www.sciencedirect.com/science/arti...
@unibe.ch @mcid-unibe.bsky.social @nccr-rna-disease.bsky.social @snf-fns.ch

🌙🔬 Our “RNA – Master of Versatility” booth at Nacht der Forschung 2025 was a hit! Big thanks to our Science Knights and amazing organizers. 💙🙌
Read more: nccr-rna-and-disease.ch/news/article...

#ndfunibern @unibe.ch

Publication by the Polacek lab & collaborators w/ co-1st authors Stefano Gallo & Anastasiia Suspitsyna "Regulation of angiogenesis and cancer cell proliferation by human vault RNA1-2 Open Access" @narjournal.bsky.social Cancer
academic.oup.com/narcancer/ar...
@unibe.ch

Publication by the Becskei & Zavolan labs w/ co-1st authors Asier González, Muskan Pandey & Niels Schlusser "Multi-omic assessment of mRNA translation dynamics in liver cancer cell lines" in Scientific Data
buff.ly/WYwzw5V
@mihaelazavolan.bsky.social
@biozentrum.unibas.ch

🔬✨ Join us this Saturday (September 6) | 16:00-23:00 at Nacht der Forschung 2025 at the University of Bern ✨ Come and check out our booth "RNA – Master of Versatility" 👩‍🔬

Meet our researchers & enjoy pipetted cocktails at the reproduzierBAR!
www.nachtderforschung.unibe.ch
#ndfunibern @unibe.ch

Wissenschaft erleben auf der Grossen Schanze! Forschung für alle, drinnen & draussen. 🗓️ Samstag, 6.9.25 ab 16 Uhr. 👉 https://unibe.ch/ndf #ndfunibern Gold auf der Grossen Schanze? #ndfunibern

Finden wir Gold auf der Grossen Schanze? Finden Sie es heraus 👉 youtu.be/fNrbVeYL6Cs.
Wollen auch Sie mehr über Ihren Boden erfahren? Dann lassen Sie ihn kostenlos an der Nacht der Forschung analysieren – einfach eine handvoll mitbringen!
📍 Am 06.09., ab 16 Uhr, Grosse Schanze Bern #ndfunibern

Wissenschaft erleben auf der Grossen Schanze! Forschung für alle, drinnen & draussen. 🗓️ Samstag, 6.9.25 ab 16 Uhr. 👉 https://unibe.ch/ndf #ndfunibern Wie heisst das hier 🍫?

An der Nacht der Forschung zeigen wir, wie vielfältig Sprache sein kann!
Kommen Sie vorbei – Eintritt frei!
📍 6. September 2025, ab 16 Uhr, Grosse Schanze Bern
www.youtube.com/watch?v=gHFn...
#ndfunibern

Wissenschaft erleben auf der Grossen Schanze! Forschung für alle, drinnen & draussen. 🗓️ Samstag, 6.9.25 ab 16 Uhr. 👉 https://unibe.ch/ndf #ndfunibern Fussball trifft Forschung #ndfunibern

Wer hat das Zeug zum Profi? ⚽ Die #Sportwissenschaft zeigt’s an der Nacht der Forschung! 👉https://www.youtube.com/watch?v=AzNyYS4v2fo.

📍06.09.2025, 16–23 Uhr, Universität Bern

#ndfunibern

Genome-wide identification of conserved RNA structure in plastids The systematic discovery of functional RNA structure directly from sequence remains a central challenge in genomics. Plastid genomes, with their deep evolutionary history and extensive data availabili...

Dolly (@dollymehta.bsky.social‬) developed a pipeline to screen for conserved #RNA structures across genomes.
She then applied it ~14,000 #plastid genomes and identified nearly 60 conserved structures.

doi.org/10.1101/2025...

Preprint by the Bukau, Kramer, Shan, Tans & Ban labs w/ co-1st authors J. Santos, M. Günnigmann, R.J. Gora "NAC promotes co-translational protein folding at the ribosomal tunnel exit" @biorxivpreprint.bsky.social
buff.ly/fd2rL15
@thebanlab.bsky.social
@ethz.ch

Preprint by the Thiel, Heller&Chao labs w/1st author Reto Lang "Stress granules formed during different RNA virus infections show remarkable plasticity &substantial virus-specific differences in their formation&composition" @biorxivpreprint.bsky.social
buff.ly/vU7Tdg6
@profvolkerthiel.bsky.social

Preprint by the Mühlemann & Ruepp labs w/ 1st author Alexander Hofer "Analysing the effect of full-length & C-terminally truncated progranulin on proliferation, colony formation, & migration in HepG2 & U87 cells" @biorxivpreprint.bsky.social
buff.ly/0BOLAJb
@omuhlemann-lab.bsky.social
@unibe.ch

Preprint by the Jinek and Martinez labs with 1st author Moritz Pfleiderer "
Structural framework for the assembly of the human tRNA
ligase complex" @biorxivpreprint.bsky.social buff.ly/9rwwEP4
@martinjinek.bsky.social
@maxperutzlabs.bsky.social

Preprint by the @sendoellab.bsky.social in collab w/ the Lutolf & Zavolan labs w/1st author David Taborsky "Regulation of mRNA polyadenylation governs mammalian body plan formation in gastruloids" @biorxivpreprint.bsky.social
buff.ly/mL3a71T
@dadita.bsky.socia
@mihaelazavolan.bsky.social

Paper by the Shan, Ban & Deuerling groups with co-1st authors Martin Gamerdinger & Blanca Echeverria "Mechanism of cotranslational protein N-myristoylation in human cells" in Molecular Cell
buff.ly/ddV1RIn
@cp-molcell.bsky.social @thebanlab.bsky.social @uni-konstanz.de @ethz.ch @caltech.edu

The 18th Edition of the NCCR RNA & Disease Newsletter - The Messenger has been published:
nccr-rna-and-disease.ch/news/article...
@omuhlemann-lab.bsky.social
@goldlab.bsky.social
@martinpacesa.bsky.social
@martinjinek.bsky.social
@unibe.ch
@ethz.ch
@snsf.ch

Preprint by the lab of Marc Bühler with first author Josip Ahel "Remodeling Activity of ChAHP Restricts Transcription Factor Access to Chromatin" @biorxivpreprint.bsky.social
buff.ly/mTYarjo
@aheljo.bsky.social
@marcbuhler.bsky.social
@fmiscience.bsky.social

Paper by the Lingner lab with 1st author Suna In "TERRA R-loops trigger a switch in telomere maintenance towards break-induced replication and PRIMPOL-dependent repair" @embojournal.org
buff.ly/4wG0reE

Publication by the Sander lab with first author Tizian Griesser "Selective inhibition of Mycobacterium tuberculosis GpsI unveils a novel strategy to target the RNA metabolism" @narjournal.bsky.social
nccr-rna-and-disease.ch/news/article...

Preprint by the lab of Marc Bühler with first author Jakob Schnabl-Baumgartner "ChAHP Silences SINE Retrotransposons by Inhibiting TFIIIB Recruitment" @biorxivpreprint.bsky.social
buff.ly/hAXKoZ3
@jakobschnabl.bsky.social
@marcbuhler.bsky.social
@fmiscience.bsky.social

Congratulations to Magdalini Polymenidou on being elected a Member of the European Molecular Biology Organization (EMBO)!
nccr-rna-and-disease.ch/news/article...
@polylab.bsky.social

New way to improve the efficacy of innovative RNA therapies A recent study involving Prof. Anne Spang from the Biozentrum, University of Basel, reveals that slowing down the intracellular transport of RNA-based drugs can significantly enhance their effectivene...

A recent study by Anne Spang @spanglab.bsky.social and Roche reveals that slowing down intracellular transport of RNA-based drugs can boost their effectiveness. These promising therapies are used to treat rare genetic diseases.@unibas.ch @natcomms.nature.com www.biozentrum.unibas.ch/news/detail/...

Welcome @mandymuller.bsky.social as new associate member of the NCCR RNA & Disease! Her lab recently moved from UMass 🇺🇸 to CHUV Lausanne🇨🇭. Now assoc. prof. at UNIL’s Institute of Microbiology, her research is on virology & RNA biology, focusing on RNA stability during infection.
@unibe.ch @ethz.ch

Preprint by the Schneider Lab ( @schneian.bsky.social‬ ) with first author Philip Stettler "Assembly of the mitochondrial outer membrane module of the trypanosomal tripartite attachment complex" @biorxivpreprint.bsky.social‬
buff.ly/IS2V6ee
‪@unibe.ch‬

Paper by the @karousislab.bsky.social‬ & @omuhlemann-lab.bsky.social‬ with first author Jana Ziegelmüller "Efficient cell-free translation from diverse human cell types" in the Journal of Biological Chemistry
buff.ly/TwKbgRp
@unibe.ch‬

🔬 Next in the NCCR RNA & Disease Seminar Series:
Prof. Rotem Karni!

📍 16.06.25 – 16:30 University of Bern, DCBP
📍 17.06.25 – 16:00 ETH Zürich, Hönggerberg

More Infos 👉 lnkd.in/dnTtsBvD

@unibe.ch @ethz.ch @snf-fns.ch

🎉 Excited to welcome Prof. Raphaëlle Luisier as Assistant Prof in #Omics Data Science for #Transcriptomics! Starting June 2, 2025, she leads research applying #AI & #bioinformatics to tackle neurodegenerative diseases & #cancer. 👉 tiny.cc/yjql001 @nccr-rna-disease.bsky.social @unibe.ch

Our method paper to produce efficient cell-free translation lysates from diverse human cell types is out 🎉 www.jbc.org/article/S002... @unibe.ch @mcid-unibe.bsky.social
@muehlemann.bsky.social @nickkouvelas.bsky.social