Martin Pacesa

It's been ~13 years ago in the lab of Grant Jensen, when Martin @pilhoferlab.bsky.social showed me how to prepare media, do first protein preps and negative stain EM. I had no idea how much more I’d learn from him over the next years - THANK YOU MARTIN for this incredible ride 🙏🙏🙏

Huge congrats to Gregor, he is a super cool and smart guy! Most certainly apply if you can

YouTube video by MRC Laboratory of Molecular Biology Structure Prediction and Design using AlphaFold – Sami Chaaban

Great talk by @sami-c.bsky.social about the proper use and caveats of AlphaFold2/3 predictions, highly recommended to watch www.youtube.com/watch?v=z7vy...

Protein-ligand complexes are all the rage with OpenBind+other efforts launching

3 amazing papers describing 229 protein-ligand structures just dropped in @actacrystd.iucr.org

A tremendous teaching text, but I disagree on the discussed potential for misuse. Read more

fraserlab.com/2025/07/29/E...

Excellent

Thank you everyone for the congratulations and the large number of applications! I want to specifically encourage applications for these positions:
* Postdoc in structural biology (cryoEM, ideally with X-ray too)
* Full time lab manager/technician with wetlab experience

Yeah fair

Yeah Roche is waaaaaaaay too high up in there

(double checked my own papers to make sure I didn’t write it too somewhere)

I agree with you, I cringe every time I see atomic structure in the title and it’s like 3A

Ouch 🤕

Congratulations Asaf!!

Kiwa is a membrane-embedded defense supercomplex activated at phage attachment sites Zhang, Todeschini, and Wu et al. show that the bacterial defense system Kiwa senses phage attachment at the membrane and assembles a transmembrane complex that halts infection by blocking phage DNA re...

Thrilled to see our Kiwa story out today! A membrane-associated supercomplex that senses infection and blocks replication and transcription.

www.cell.com/cell/fulltex...

Huge congratulations to Yi and Zhiying for bringing it home, to Thomas for starting us off, and to all the collaborators.

Stay tuned for details on the 6th edition of MLSB, officially happening this December in downtown San Diego, CA!

A two year post-doctoral position at the BacterialGenome Plasticity Unit starting October 1st - Research

Postdoc position to work at the Institut Pasteur with Alex Kaminski and Didier Mazel on Z-DNA phages ! research.pasteur.fr/en/job/a-two...

Due to some server issues, some applications have been lost, particularly the ones submitted within 12h of the announcement, if that’s your case, it’s better to resubmit, sorry everyone 🙏🏻

Thank you Leo ❤️

We notified authors about the helical nature of the peptides, the default settings make exclusively helices for peptides to increase success rates, one has to change the helicity settings to get more diversity.

Excellent nanomolar peptide design success rates with BindCraft!

Thank you Sjors!

HOW COOL IS THIS? Researchers have developed a DENTAL FLOSS that can DELIVER vaccines THROUGH the gums, a method that could one day offer a NEEDLE-FREE alternative for vaccination. This approach effectively stimulated immunity AND provided FULL protection against a lethal strain of influenza. 🧪🧵⬇️

So cool!

Too kind ❤️

Thank you Pavel!

Thanks Marcin, that’ super kind ❤️

Submit your application with attached CV and motivation letter to applications@pacesalab.com (applications elsewhere will be ignored). Apologies up front if I won’t be able to reply to everyone!

I am looking to interview prospective PhD students, Postdocs and technicians, particularly with wetlab expertise, but computational skills are a bonus.

We will be focusing on marrying high throughput structural biology methods, protein design, and AI to model and characterise dark parts of the protein-nucleic acid interactome.

I am super excited to announce that I will be starting my lab at the Department of Pharmacology of the University of Zurich in Switzerland next year!

16 🫠