Cassie Bakshani

PNGaseA-mediated N-glycan stripping from peptides by infant-derived Bifidobacterium bifidum N-glycans are highly common sources of nutrition for human colonic-dwelling bacteria. These microbes have evolved a several methods to remove N-glycans from proteins; herein we describe the biochemica...

🚨 New preprint klaxon 🚨
We characterised the structure of a PNGaseA superfamily member from Bifidobacterium bifidum LMG13195 and highlight its preference for N-glycan structures attached to a peptide, rather than to a native or denatured protein 💫 @imibirmingham.bsky.social

PNGaseA-mediated N-glycan stripping from peptides by infant-derived Bifidobacterium bifidum N-glycans are highly common sources of nutrition for human colonic-dwelling bacteria. These microbes have evolved a several methods to remove N-glycans from proteins; herein we describe the biochemica...

New Pre-print! “PNGaseA-mediated N-glycan stripping from peptides by infant-derived Bifidobacterium bifidum”. This is the first manuscript from the Bifidobacterium and breast milk project🍼🤱👶in collaboration with van Sinderen and Lovering groups
www.biorxiv.org/content/10.1...

PNGaseL from Flavobacterium akiainvivens targets a diverse range of N-glycan structures PNGases are used by a wide range of organisms to remove N-glycan structures from proteins for use as either nutrients or in glycoprotein processing. PNGaseF is the most well-characterised enzyme of th...

Very pleased to present the next pre-print from our lab #glycotime We showcase PNGaseL from Flavobacterium akiainvivens that we hope will be a useful tool for the glyco community 🍬🧪👩‍🔬 Special shout out to @cassiebakshani.bsky.social and Paulina (Ludger)
www.biorxiv.org/content/10.1...

@sambenedict5.bsky.social and I loved hosting this!! Super fun and informative workshop with loads of practical insights for making better, more accessible, figures! Thanks so much Ali 💫

The Last of Us: Developing a Genomic Epidemiology Toolkit for Fungal Outbreaks at University of Birmingham on FindAPhD.com PhD Project - The Last of Us: Developing a Genomic Epidemiology Toolkit for Fungal Outbreaks at University of Birmingham, listed on FindAPhD.com

🍄The Last of Us - NIHR HPRU PhD opportunity🍄 Very exciting project on developing a genomic epidemiology toolkit for fungal outbreaks with @mcdonaldmeganc.bsky.social @drjorhodes.com @scalene.bsky.social and the Mycological Reference Lab Bristol www.findaphd.com/phds/project...

**NEW Doctoral Training Programme just launched!!** This exciting programme on Microbial Genomics for Health Protection is joint between @imibirmingham.bsky.social and UKHSA @ukhsa.bsky.social. 9 brilliant projects available!!

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This is wonderful news Ilyas, congratulations!! 💫

This mucus-loving gut bacteria is important for health – here’s how to keep it happy Akkermansia muciniphila is a friendly bacteria which is linked to good immune function.

How to keep mucus-loving gut bacteria happy, in my new article with @uk.theconversation.com theconversation.com/this-mucus-l...

Woo congrats Bex!! ☺️

Glucose alters the evolutionary response to gentamicin in uropathogenic Escherichia coli Urinary tract infections (UTI) are a major health and economic concern. Uropathogenic Escherichia coli (UPEC) are the leading cause of UTI, and antibiotic-resistant UPEC are increasingly common. The m...

A happy Friday seeing this out! I lucked out and got to work with a couple of really great students on this, Shalini and Jacob, and I’m super proud to see their hard work rewarded #microsky

www.microbiologyresearch.org/content/jour...

Thank you Jose! ☺️

Carbohydrate-active enzymes from Akkermansia muciniphila break down mucin O-glycans to completion - Nature Microbiology Biochemical characterization of 66 carbohydrate-active enzymes from the gut microorganism Akkermansia muciniphila reveals that these enzymes can break down a range of host glycans, including mucin, wh...

OUT NOW: Carbohydrate-active enzymes from Akkermansia muciniphila break down mucin O-glycans to completion

@lucyicm.bsky.social @cassiebakshani.bsky.social

#microsky 🧪

www.nature.com/articles/s41...

Carbohydrate-active enzymes from Akkermansia muciniphila break down mucin O-glycans to completion - Nature Microbiology Biochemical characterization of 66 carbohydrate-active enzymes from the gut microorganism Akkermansia muciniphila reveals that these enzymes can break down a range of host glycans, including mucin, wh...

Our work on Akkermansia muciniphila utilisation of host glycans is out today. Huge thanks to our team and wonderful collaborators. Super proud of this one! 💫 @lucyicm.bsky.social @imibirmingham.bsky.social

www.nature.com/articles/s41...

Carbohydrate-active enzymes from Akkermansia muciniphila break down mucin O-glycans to completion - Nature Microbiology Biochemical characterization of 66 carbohydrate-active enzymes from the gut microorganism Akkermansia muciniphila reveals that these enzymes can break down a range of host glycans, including mucin, wh...

New paper out today from the lab on Akkermansia muciniphila 🦠and how it breaks down host glycans! Very proud of my group, especially @cassiebakshani.bsky.social who did an amazing job. @naturemicrobiol.bsky.social

www.nature.com/articles/s41...

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Decoding Early Life Microbiota and Host Interactions at University of Birmingham on FindAPhD.com PhD Project - Decoding Early Life Microbiota and Host Interactions at University of Birmingham, listed on FindAPhD.com

🚨 PhD Opportunity @halllab.bsky.social!
🔬 Decoding Early Life Microbiota & Host Interactions
🧬 Ideal for those with bioinformatics/microbiome experience
🌍 Open to international candidates (MSCA mobility rules apply).
📅 Deadline: 18th Dec
🌐 Apply now: www.findaphd.com/phds/project...

Glucose alters the evolutionary response to gentamicin in uropathogenic Escherichia coli Urinary tract infections (UTI) are a major health and economic concern. Uropathogenic Escherichia coli (UPEC) are the leading cause of UTI, and antibiotic resistant UPEC are increasingly common. The m...

🚨 New preprint 🚨

With two excellent students Shalini Choudhary and Jacob Smith, we started looking at how the metabolic microenvironment of the urinary tract might affect uropathogenic E. coli evolution and response to antibiotics.

www.biorxiv.org/content/10.1...

I have three PhD studentships available currently through the MIBTP DTP warwick.ac.uk/fac/cross_fa... on different aspects of the respiratory microbiome, interaction with mucin with @lucyicm.bsky.social, the resistome with Dr Michelle Buckner and pathobionts with @bacterioskeptic.bsky.social

PhD studentship alert!! Two projects available with me fully funded by BBSRC

This one is a collaboration with Dr Michelle Buckner
warwick.ac.uk/fac/cross_fa...

And this one a collaboration with @overtonlab.bsky.social warwick.ac.uk/fac/cross_fa...

Both will be lots of fun! Come & join us 😃

Thanks Bex! 🫶

Cassie Bakshani giving a fantastic talk on her work on Akkermansia enzymes breaking down host glycans #cbm15 #glycotime