Uwe Töpfer

Drosophila SPARC Collagen IV chaperone-like activity essential for development is unique to the fat body Drosophila fat body-derived SPARC acts as a chaperone for Collagen IV (Col(IV)), enabling their diffusion and incorporation into distal tissue basement membranes (BMs). Disruption of SPARC or Col(IV) ...

Drosophila SPARC Collagen IV chaperone-like activity essential for development is unique to the fat body

www.cell.com/iscience/ful...

Macrophage invasion into the Drosophila brain requires JAK/STAT-dependent MMP activation in the blood–brain barrier The blood-brain barrier prevents immune cells and pathogens from entering the brain. This study shows that during neuroinflammation in Drosophila, immune cells can cross the blood-brain barrier by deg...

Macrophage invasion into the Drosophila brain requires JAK/STAT-dependent MMP activation in the blood–brain barrier

journals.plos.org/Plosbiology/...

Remodeling of extracellular matrix collagen IV by MIG-6/papilin regulates neuronal architecture Neuronal architecture established embryonically must persist lifelong to ensure normal brain function. However, little is understood about the mechanisms behind the long-term maintenance of neuronal o...

Remodeling of extracellular matrix collagen IV by MIG-6/papilin regulates neuronal architecture

www.biorxiv.org/content/10.1...

Dear Droso peeps, we re-announce the upcoming JEDI meeting that will take place at Château du Feÿ from June 3rd to 5th in 2025.
You'll find a prelim program flies-jedi.github.io/projects/202...
We're hoping to gather about 45 of more or less young droso PI to reboot the community.
-> Register Now!

A great initiative to spread the use of non-mammalian models in cancer research!!!!

Open Positions -

We are recruiting one postdoc and one PhD student to join our lab on #Drosophila #innate immunity in Lausanne (Switzerland). More info: www.epfl.ch/labs/lemaitr...

"Imagine a DAPI-like stain, but for the extracellular matrix." That's basically how this work was pitched to me by Kayvon and Antonio a year or so ago. Now the final product really delivers. Read about their versatile label for ECM in living tissues here: www.nature.com/articles/s41...

Mechanical stresses govern myoblast fusion and myotube growth Myoblast fusion into myotubes is critical for muscle formation, growth and repair. While the cellular and molecular mechanisms regulating myoblast fusion are increasingly understood, the role of biome...

Mechanical stresses govern myoblast fusion and myotube growth

www.biorxiv.org/content/10.1...

On-demand delivery of fibulin-1 enables repeated basement membrane stretching Basement membrane (BM) extracellular matrices enwrap and structurally support tissues. Whether BMs are uniquely constructed to support tissues that undergo repetitive stretching and recoil events is u...

On-demand delivery of fibulin-1 enables repeated basement membrane stretching

www.biorxiv.org/content/10.1...

🪰 🧬 Do you want to enhance your knowledge of Drosophila as a model organism? Then 'Drosophila genetics and genomics' might be the right course for you!

Apply now and join us in Heidelberg for lectures and practical sessions delivered by renowned experts 👉 s.embl.org/drg25-01-bl

#EMBODrosophila

Development | The Company of Biologists

Welcome to Development's Bluesky account 🧪

Development is a leading primary research journal in developmental and stem cell biology, published by The Company of Biologists @biologists.bsky.social, a not-for-profit organisation, and edited by expert researchers in the #DevBio field.

The Company of Biologists publishes multiple non-profit journals run by and for scientists across many fields, and also supports the community through meeting and travel grants and other innovations. Follow them all!

YouTube video by The Company of Biologists FocalPlane features... reproducibility in imaging

ICYMI: The October FocalPlane features… webinar included talks from @helenajambor.bsky.social (‘How not to lie with image data’) and Kota Miura ('Reproducible bioimage analysis for ensuring #scientificintegrity').

Watch the recording at
bit.ly/4fyB2SU

#PublicationIntegrityWeek #COPE

Dev Mech 2024-25 logo

Since I have so many new friends 😄, I thought I'd advertise this. Together with @pritiagarwal.bsky.social and Lance Davidson, we run a Developmental Mechanics seminar series on Zoom (originally started by Ronen Zaidel-Bar). This coming Thursday, we have our last session for 2024. Join us!!

Even though there are great #devbio and #biophysics starter packs, I felt #morphogenesis & #organogenesis was missing as a subfield :D

Far from complete or full. Tell me if you want to be added!
go.bsky.app/PB6s8PQ

Thank you!

Could you please add me?

Download our database of 492 (!) funding opportunities for EARLY-CAREER FACULTY AND RESEARCHERS.

For each entry, we provide link to funder, description, amount, deadline, and eligibility criteria (e.g. citizenship).

Download freely here: research.jhu.edu/rdt/funding-...

Developmental processes don't just occur in the embryo!

Development's (@biologists.bsky.social) next Special Issue - Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues. Papers: 15 May 2025. #devbio #regeneration #stemcells

journals.biologists.com/dev/pages/li...

Can you please add me?

Very cool! Could you please add me?

Very cool! Can you please add me?