Yanín Guerra

Geng, @kjverhey1.bsky.social et al find that KIF1C forms condensates where the exposed #kinesin motor domains entangle nearby #microtubules, causing them to bend & break in a process dependent on motor processivity, cluster properties, cytoplasmic viscosity, & MT anchors rupress.org/jcb/article/...

Best paper title?: “How to make a new nose for someone when it is off entirely and the dog has eaten it”—c.1460 von Pfalzpaint.

I talk noses: @npr.org Shortwave (Regina Barber) tinyurl.com/23dvwzmv

Video of my nightclub version @oddsalon.bsky.social
tinyurl.com/4snnacs3

#storiesmatter
(my art)

Regulation of epithelial tissue homeostasis by active trans-epithelial transport Epithelia are intricate tissues whose function is intimately linked to mechanics. While mechanobiology has primarily focused on factors such as cell-generated contractility and mechanical properties o...

Happy to share our new study @ijmonod.bsky.social and @mpi-scienceoflight.bsky.social with C. Duclut and J. Prost. on forces generated by active fluid transport in epithelia and their role in tissue dynamics.
Congrats to Huiqiong Wu, G. Arkowitz and R. Chilupuri!
www.biorxiv.org/content/10.1...

SCHEPHERD--the bioelectric cell herding platform built for YOU. Single cells, monolayers, organoids--this herds them all + new tricks. Plz try it-- we will *give* you parts! Teaser here of a steering a single cell. GS Yubin Lin's lifeblood with J. Yodh on piano; Celeste R. and Paul K. Thread 1/N

Now #published @pnas.org: "A model for boundary-driven tissue morphogenesis", a great #biophysics #devbio collaboration led by @danielalber.bsky.social @zhaoshh.bsky.social:

doi.org/10.1073/pnas.2505160122

@mpipks.bsky.social @mpi-cbg.de @csbdresden.bsky.social @flatironinstitute.org

Tipsy bats and perfect pasta: Ig Nobels celebrate ‘improbable’ research The annual awards are a celebration of weird but thought-provoking science.

IG Nobel Prize in #Physics 2025 to @mpipks.bsky.social researchers for elucidating the phase behaviour of cacio e pepe sauce. The work highlights how physics can also be applied to solve daily-life problems!

nature.com/articles/d41586-025-03045-0

How epithelial junctions mature: Study shows conformational transition in key protein Epithelial tissues cover the inner and outer surfaces of the body. A study by the working group of cell biologist Prof. Carsten Grashoff now provides insight into the molecular details underlying the ...

Epithelial tissues cover the inner and outer surfaces of the body. A study by the working group of cell biologist Prof Carsten Grashoff now provides insight into the molecular details underlying the formation of the connections between epithelial cells. #Biology

Congratulations to postdoc Arthur Boutillon at the Campàs lab @campaslab.bsky.social for a beautiful cover image selected for the latest Development issue @dev-journal.bsky.social!

First day as a KITP postdoc and a member of the Streichan group. Excited to learn some cool stuff!

The actin cortex acts as a mechanical memory of morphology in confined migrating cells - Nature Physics Cells often navigate through confined spaces. Now it is shown that cells retain a mechanical memory of previous confinement events, which makes them more efficient at migrating through narrow microenv...

Excited to share our new publication in Nature Physics about the mechanical memory of morphology in confined migrating cells by @kyohalie.bsky.social 🥳

Super fun collab with @davidbrueckner.bsky.social and @gcharras.bsky.social 👏🏻

Enjoy the reading www.nature.com/articles/s41...

Dynamic Landscape Analysis of Cell Fate Decisions: Predictive Models of Neural Development From Single-Cell Data Building a mechanistic understanding of cell fate decisions remains a fundamental goal of developmental biology, with implications for stem cell therapies, regenerative medicine and understanding dise...

Our latest "Dynamic Landscape Analysis of Cell Fate Decisions: Predictive Models of Neural Development From Single-Cell Data"

A rigorous mathematical foundation for Waddington's landscape to study cell fate decision making

Applied to ventral neural tube development

www.biorxiv.org/content/10.1...

Supracellular control and coordination of tissue morphogenesis, through supracellular actomyosin assemblies, that is what my lab @cellbiol-mrclmb.bsky.social @pdncambridge.bsky.social and I like to dig into at the moment! Fascinating and beautiful! journals.biologists.com/dev/article/...

Quantifying convergent extension: Shih and Keller's quintessential work in developmental cell biology Few biological fields have become more intertwined in recent years than cell and developmental biology, a fact made clear by the departments of cell a…

One the best things about a life in science is that your heroes often become your friends. My entire career stems from two papers by Ray Keller and I'm just thrilled to have a new piece out with Rob Huebner highlighting those classic papers.

www.sciencedirect.com/science/arti...

Through RNAi knockdowns, we dissected roles of major ECM players:
• Collagen IV → essential to form fibers
• Laminin + Collagen IV → smooth groove-like indentations
• Nidogen → maintains grooves
• Perlecan → boosts pattern amplitude across all scales

We found the surface is “self-affine” (structurally similar across scales) and features thin, fiber-like ridges aligned mainly along the anterior-posterior axis. Nature’s fractals at work! 🌿 #Fractals #Morphogenesis

🧬 New paper alert! We used AFM PeakForce tapping to map the nanoscale topography of the basement membrane in Drosophila wing discs—revealing unexpected fiber-like and self-affine structures. #BasementMembrane #AFM
www.sciencedirect.com/science/arti...

Tagging @mpi-cbg.de @poldresden.bsky.social

🥁 New article 📢: #Mechanobiology of #development during #Drosophila #gastrulation using #Brillouin microscopy, now in @natcomms.nature.com : rdcu.be/ev6ZX
Collab. w/ @Prevedel_Lab @embl.org , Maria Leptin @marialep.bsky.social, @abhisha-thayambath.bsky.social, Julio Belmonte @ncstate.bsky.social

Congratulations to the Friedrich group at PoL
@friedrich-group.bsky.social and the group of Frank Schnorrer
@frankschnorrer.bsky.social at IBDM @ibdm.bsky.social
for their new publication on the cover of Science Advances!

Check out the paper below⤵️

Transitions in development – an interview with Natalie Dye

In this interview, @natalieadye.bsky.social talks about her research interests, her path to becoming a group leader @mbisg.bsky.social, and the importance of finding a supportive network of peers and mentors.
doi.org/10.1242/dev....

🚨 Second preprint of the week!

We uncover the multiscale dynamics of active viscoelastic buckling in epithelia.

We harness these mechanical instabilities for synthetic morphogenesis.

Led by @onenimesa.bsky.social 🙌. Theory by Marino Arroyo etal. @ibecbarcelona.eu

www.biorxiv.org/content/10.1...

Emergence of cellular nematic order is a conserved feature of gastrulation in animal embryos Nature Communications - The morphogenetic events that occur during gastrulation involve dramatic cell- and tissue-level changes. Here they show that propagation of nematic order, leading to...

Scientific collaborations come in many flavors & are fun because they expose you to new areas of science. That was definitely the case for this paper, out today. We were definitely in the passenger seat but it was fun to go along for the ride 1/n
rdcu.be/euiZB.

HFSP Postdoctoral Fellowship for Augusto Ortega Granillo Fellowship for investigating the role of osmotic and hydrostatic pressure during pancreas lumen formation.

Augusto Ortega Granillo, postdoc in the groups of @anne-grapin.bsky.social @mpi-cbg.de & @campaslab.bsky.social @poldresden.bsky.social, received a postdoctoral fellowship from the @hfspo.bsky.social! Congratulations! 🎉 www.mpi-cbg.de/news-outreac...

Our #DatascapeRealities new exhibition featured on BBC!

Weizmann Institute rn

Integrins coordinate basal surface contraction and oriented cell growth to enable thickening of a curved epithelium During development, tissues undergo morphogenesis to achieve their final form. This process relies on coordinated cell shape changes, which have predo…

Delighted to share our latest work on the mechanisms of epithelial curvature and 3D morphogenesis ! Amazing work from newly graduated Dr @courtneyl7a7.bsky.social 🎉

@lmcb-ucl.bsky.social
@uclnews.bsky.social
@ucllifesciences.bsky.social

www.sciencedirect.com/science/arti...

YouTube video by MPIPKS Tiny swimmers

🐠🦠Why can’t bacteria swim like fish?
At microscopic scales, physics changes — viscosity rules! Researchers at our institute study how microbes like E. coli overcome this challenge with clever strategies like run-and-tumble.

Watch our new video:

youtu.be/drwCRRD7CGY?...

🔔 Proud to share the preprint of my PhD work in the Petridou group @nicolettapetridou.bsky.social @embl.org ✨

“A closed feedback between tissue phase transitions and morphogen gradients drives patterning dynamics” 🐟 🔁 📶

🔗 www.biorxiv.org/content/10.1...

#devbio #biophysics

🧵⤵️

📣 New paper out! How do thousands of cells shape the emergent geometry of the avian embryo? We identify distinct, independently controllable mechanisms that contribute to embryo size and shape. @alex-plum.bsky.social @bensteventon.bsky.social @Guillermo Serrano Najera
www.nature.com/articles/s41...

Chemical and mechanical patterning of tortoise skin scales occur in different regions of the head Biological sciences; Zoology; Evolutionary biology

Excited to share our new research in @cp-iscience.bsky.social! We reveal that tortoise head scales are sculpted through two distinct developmental processes - chemical signalling and mechanical folding 🐢🔬🧪
@lanevol.bsky.social @genevunige.bsky.social

www.cell.com/iscience/ful...