Murli Mishra MD PhD

Efficacy and safety of minocycline in patients with acute ischaemic stroke (EMPHASIS): a multicentre, double-blind, randomised controlled trial Minocycline therapy initiated within 72 h of acute ischaemic stroke provided a significant functional outcome benefit compared with placebo at 90 days, without safety concerns. Future studies are need...

This study exemplifies how drug repurposing research can still meaningfully benefit patients in vascular neurology. Such approaches offer a promising, cost-effective path to future drug discovery for those affected by stroke.
#stroke #Neurology

www.thelancet.com/journals/lan...

Striking gap: ~20x recruitment incentives in non-academic vs academic vascular neurology. Many choose academia for research, teaching & impact. Are we appropriately investing in what sets us apart?
#Stroke #VascularNeurology #AcademicMedicine #Neurology

www.linkedin.com/posts/murlim...

Reflecting on Predatory Journals and the Pressures Shaping Modern Academia: Is the Publish‑or‑Perish Mindset Fueling Predatory Publishing? As conversations around predatory journals continue to surface, I often find myself asking a deeper set of questions: How did we get here? Who enabled the growth of this ecosystem? Who sustains it? An...

I’m curious to learn from your experiences and perspectives. How do you think we can collectively shift toward more meaningful research practices?
#Academia #Neurology #Medsky #Neurosky
www.linkedin.com/pulse/reflec...

Here is a link to the free full text:
doi.org/10.1016/j.js...

A urine-based point-of-care test for Factor Xa inhibitors in acute stroke management For stroke patients with history of possible Direct Acting Oral Anticoagulant use, clinicians must make treatment decisions without knowledge of whether the patient is therapeutically anticoagulated. ...

Here is our new publications:
A urine-based POC test for Factor Xa inhibitors: Ideal for patients presenting with acute neurological / stroke symptoms when the last Factor Xa inhibitor dose is unclear. It may be a game-changer for many patients
www.strokejournal.org/article/S105...

Heard stories of similar companies raising incredible amount of funds during dotcom bubble. It makes me wonder if AI bubble rumors are true

a rainbow colored background with the words feedback please and a microphone ALT: a rainbow colored background with the words feedback please and a microphone

I've never used anonymous surveys for real criticism.

Feedback works best when it’s open and accountable. Leaders need to know who's speaking so they can reach out and discuss solutions rather than guessing. Let's champion openness for true improvement. #Leadership

#Neurology never stops amazing me. Had an amazing case of monocular quadrantanopia on initial exam that turned out to be ischemic stroke. Differential based on CT included Temporal Crescent syndrome findings, but I had never seen a case. Here is the link:
eyewiki.org/Monocular_Oc...

Received news that all three abstracts from my fellowship research at UTHouston were accepted for #ISC2026 (and one at #SVIN2025). Grateful to have an awesome team.

Looking forward to connecting with colleagues in New Orleans.

#Stroke #CRAO #AHA_ASA

It’s been 4 months since my last post here. 1/3rd of #stroke fellowship completed. It’s been very eventful 4 months. 8 more months of training remaining before we can call ourselves PGY-Old

#VascularNeurology

The variety of flowers in my backyard garden today
#Memories #Gardening #Nashville

Done with last weekend day of work in residency. No overnight calls, no weekend shifts for remaining weeks of residency
#neuro

Why is it essential to find more human-relevant toxicity testing approaches? Adverse outcome pathway (AOP) is a mechanistic toxicology based non-chemical structure particular methodology of risk assessment. AOPs mainly try to identify the major events or steps that occur betwe...

This month, US FDA @fda.gov announced that animal testing will be phased out! This echoes my article from years ago about pushing for alternatives. #AnimalTesting #Innovation

"Why is it essential to find more human-relevant toxicity testing approaches?" Link: www.linkedin.com/pulse/why-es...

Med Myth reminder:

If a patient hasn’t used 75% of prescribed meds in 9 months, it’s not treatment failure or a side effect. Adding more meds won’t help. Investigate non-compliance reasons first.

They self-reported? Just listen.

Listening is essential to the art of medicine

The biggest advantage of having great juniors @VUMCneurology is that once you design a project, others are willing to take it to the finish line. After getting IRB approval, I barely contributed 10% to it. Here is full text:
#PNES #FND
doi.org/10.1016/j.se...

Cerebrovascular reactivity and response times describe recent ischaemic symptomatology in patients with moyamoya - PubMed Moyamoya is a non-atherosclerotic intracranial steno-occlusive condition that places patients at high risk for ischaemic stroke. Randomized trials of surgical revascularization demonstrating efficacy ...

Here is the full-text link to our recent article related to neuroimaging findings in Moyamoya disease
#Neurology
pubmed.ncbi.nlm.nih.gov/39801713/

Indianapolis trip is incomplete before stopping at Hyderabad House and getting some biryani

Enjoying our newsletters? I’m thrilled to share we’re working on something even bigger for neurology trainees & practitioners, launching by the end of this academic year. 🚀

Stay tuned—exciting updates are coming soon!

Landmark Articles Our team has selected what we feel is a compilation of some “landmark” neurology journal articles, and included a short summary of each. Please note, that neurology examinations do not ...

Since the very first @NowyouknowNeuro newsletter in July 2022, I’ve been part of this incredible journey. Now, with 36 landmark articles, our newsletter project is officially complete!
You can catch up on them here:
www.nowyouknowneuro.com/landmark-art...

This CT head shocked me until I found out what’s going on. Any guesses?

#Neurosky #Medsky #Radiology

Promoting a toxic person or a sycophant and expecting them to be a great leader is like planting weeds and hoping for roses. Leadership demands & thrives on integrity, not ego or flattery.
#Leadership

Every time I see a patient for a second opinion who was recommended to see a psychiatrist for neurological symptoms that clearly have an organic origin, I realize some doctors have a hard time saying, "I don't know".

Asymmetric dystonia, contraction, and hypertrophy are not psychological.
#FND

If a junior trainee wants to quit a specialty after working with your department, check:
1. Schedule
2. Leadership
3. Team dynamics
4. Selection process

100% chance you failed at one of the above.
>95% chance you failed more than one of the above.
#Medsky #neurosky

100% correct

Adult live patient

Live patient

This CT head shocked me until I found out what’s going on. Any guesses?

#Neurosky #Medsky #Radiology

2/ We must address functional overlay as a potential comorbidity in neurological symptoms. Educating patients that symptom exaggeration doesn't help—and can sometimes harm—is crucial for their care and trust. Compassionate honesty >>> confusion.
#FND #Neurosky

As neurologists, we must be clear with patients: treatments like IVIG are unlikely to work for Functional Neurological Disorders. Offering ineffective options breeds mistrust. If you're unsure, saying 'I don't know' is far better than false hope.
#FND @fndsociety.bsky.social #Neurosky #Medsky

Thank you for sharing your experience. I usually limit Maxeran to 40 mg due to plateaued effect above that dose and drowsiness in 1/5th of patient by that dose but would consider it in future if appropriate for individual case. Wondering if intranasal lidocaine is possible outpatient though