The Lancet Neurology

Promotional card. Contact Heather Brown regarding content enquiries at heather.brown@lancet.com. Copyright: Elsevier Ltd.

Attending the 2025 European Headache Congress? Heather Brown, Senior Editor @thelancetneuro.bsky.social, invites you to reach out with enquiries. Explore our scope, reach & impact, commitment to publishing excellence, & more: hubs.li/Q03BKqbs0

A nurse carries out a blood test on a man with multiple sclerosis. Image ©ASTIER / BSIP / SCIENCE PHOTO LIBRARY

ICYMI: our December issue includes an overview of the evidence for blood and CSF biomarkers, including their potential clinical applications, in patients with multiple sclerosis. Read the Review by Tanuja Chitnis and colleagues here:
www.thelancet.com/journals/lan...

Blue graphic with Cell Press and The Lancet logos in the top left and right corners respectively. Text says: "Webinar: Innate immunity regulation of brain health on Thursday, November 20, 2025 at 2pm GMT/9am EST/10pm CST. Join Elena Becker-Barroso, Editor-in-Chief at The Lancet Neurology, Sam Rose, Scientific Editor at Neuron, David Hunt, Professor of Medicine at University of Edinburgh, Andrea Ablasser, Professor at EPFL, and Manuel Friese, Professor of Neurology at University Medical Center Hamburg-Eppendorf". Copyright: Elsevier Ltd.

📢 Don't miss our upcoming webinar with Cell Press!

Register now to join the discussion and explore how innate immunity shapes neurological diseases by examining its protective and harmful roles in the brain.

👉 Register: hubs.li/Q03NdTNP0

#neurology #brainhealth #alzheimers #multiplesclerosis

Global, regional, and national burden of headache disorders, 1990–2023: a systematic analysis for the Global Burden of Disease Study 2023 Headache disorders, in particular migraine, continue to be a major global health challenge, emphasising the need for effective management and prevention strategies. Much headache-attributed burden could be averted or eliminated by avoiding overuse of medication (including over-the-counter medication), underscoring the importance of public education.

ICYMI: new analysis from the Global Burden of Disease Study 2023 presents updated results on headache-attributed burden from 1990 to 2023, along with clinical and public health implications: thelancet.com/journals/lan...

Ian McKeith on dementia with dementia with Lewy bodies - The Lancet Neurology in conversation with In this episode, host Antonia Eisenkoeck, speaks with Ian McKeith, Emeritus Professor of Old Age Psychiatry at Newcastle University, UK. They delve into the history of dementia with Lewy bodies resear...

LISTEN: In the latest podcast episode, host Antonia Eisenkoeck speaks with Ian McKeith. They delve into the history of dementia with Lewy bodies research, highlighting key milestones and breakthroughs: www.buzzsprout.com/1391383/epis...

Advances in Dementia with Lewy Bodies Lewy body dementia is a neurodegenerative disorder characterised by the accumulation of misfolded α-synuclein. The disease can disrupt cognitive function, motor function, autonomic regulation, and sle...

SERIES: A collection of three papers highlight the latest advancements in basic and clinical research that are transforming the approach to disease management in Lewy body dementia: www.thelancet.com/series-do/de...

Blood and CSF biomarkers for multiple sclerosis: emerging clinical applications Neurofilament light chain (NfL), glial fibrillary acidic protein (GFAP), chitinase-3-like protein 1 (CHI3L1), and other protein assays are being developed as diagnostic or prognostic biomarkers in mul...

In a Review, Tanuja Chitnis and colleagues provide an overview of the emerging evidence from studies that have assessed blood and CSF biomarkers and their clinical associations in patients with multiple sclerosis: thelancet.com/journals/lan...

Lifetime and 10-year absolute risk of cognitive impairment in relation to amyloid PET severity: a retrospective, longitudinal cohort study Lifetime and 10-year absolute risk for MCI and dementia among individuals who are currently cognitively unimpaired increase with increasing biological severity of Alzheimer's disease. This information...

In their Article, Clifford Jack and colleagues compute lifetime and 10-year absolute risk of cognitive impairment as a function of continuous amyloid PET: thelancet.com/journals/lan...

Global, regional, and national burden of headache disorders, 1990–2023: a systematic analysis for the Global Burden of Disease Study 2023 Headache disorders, in particular migraine, continue to be a major global health challenge, emphasising the need for effective management and prevention strategies. Much headache-attributed burden cou...

The latest analysis of data from the Global Burden of Disease Study 2023 presents updated results on headache-attributed burden from 1990 to 2023, along with clinical and public health implications: thelancet.com/journals/lan...

The cover of the December 2025 issue of The Lancet Neurology, showing a head superimposed with lines, dots, and a digital countdown clock at zero. Cover image by Shonagh Rae

NEW ISSUE: Read the latest content on: Lewy bodies research, the global burden of headache disorders, brain amyloid and risk of cognitive impairment, biomarkers for multiple sclerosis, and more at:
thelancet.com/journals/lan...

Quote from the Lancet's Oct 25, 2025 Editorial. Quote reads: "The dysfunctionalities of the pharma business model will not be solved by ramping up drug prices."

The UK is facing a pharma exodus, driven by claims that insufficient NHS investment threatens pharmaceutical innovation.

Yet, evidence suggests that the current pharma business model prioritises shareholder profits over innovation.

Find out more in an Editorial: tinyurl.com/n4pczpzx

Offline: “People have died” The World Health Summit has proved itself the premier global health event of the year. Under the banner “Taking responsibility for health in a fragmenting world”—symbolised by a giant stage globe crac...

"Politicians may forget...Communities do not."

In his latest Offline, Richard Horton reflects on the recent World Health Summit, where global health leaders grappled with the aftermath of the US' sudden withdrawal of funding from @who.int: tinyurl.com/mr3bjs85

Comment published in The Lancet entitled "Special issue on neurology: call for papers".

📢 Call for papers 📢

There is still time to submit to our call for papers for a special issue on neurology. Deadline: Oct 31, 2025

Find out more 👉 tinyurl.com/4fwjttu2

The Lancet Neurology in conversation with Editors at The Lancet Neurology, in conversation with the journal’s authors, explore their latest research and its impact on people’s health, healthcare, and health policy.A monthly audio companion to...

Have you listened to our latest podcast on long-term stroke risk in women yet? Check it out here: thelancetneurology.buzzsprout.com

Panel listing the aims of the Global Parkinson's Genetics Program (GP2). Copyright: 2025 Published by Elsevier Ltd.

"...the outcomes of this work will be crucially important and will accelerate the path towards a treatment for every patient."

A new Comment discusses emerging opportunities through global collaboration for Parkinson's disease: tinyurl.com/mr3b49ex

November issue live! Featuring a Series on intracranial aneurysms, Personal Views on issues related to Parkinson's disease, cutting-edge research on stroke risk, treatment for acute central retinal artery occlusion, & amyloid-related imaging abnormalities in Alzheimer's disease: tinyurl.com/4bt9bcjf

The quality of life of patients with dementia and their caregivers: important and yet inadequately assessed Dementia is one of the most pressing challenges for health and social care globally, with an estimated annual economic burden of £42 billion in the UK alone. The specific toll on individuals and…

'The quality of life of patients with dementia and their caregivers: important and yet inadequately assessed' - read our most recent InContext piece here:

The Lancet Series on Alzheimer’s disease The initial successes of anti-amyloid β monoclonal antibodies offer new perspectives for improving the clinical trajectory of Alzheimer’s disease for the first time since its identification in 1906.

A new 3-part series on the new advances in Alzheimer's disease research has just been published by @thelancet.com. Check it out here: tinyurl.com/2ubpaap3

Join our webinar on reporting race and ethnicity data in research, taking place October 23, 2025. Copyright: Elsevier Ltd.

📢 Join our webinar on reporting race and ethnicity data in research

📆 Oct 23, 11am BST
👉 Register: hubs.li/Q03GrSg00

Our editors will guide you through our requirements for reporting race and ethnicity in your research, and share practical tips for all article types.

Financing policies to sustain improved prevention, control, and management of non-communicable diseases and mental health conditions All countries have pledged to tackle the growing burden of non-communicable diseases and mental health conditions, but financing has not followed. This Health Policy summarises the background research...

Pledges have been made to tackle the growing burden of non-communicable diseases (NCDs) & mental health conditions—but financing has not followed.

Ahead of the #UNGA high-level meeting on NCDs, explore 7 key actions to improve financing & health outcomes: tinyurl.com/49vnsxad @lancetgh.bsky.social

Blood and CSF biomarkers for multiple sclerosis: emerging clinical applications Neurofilament light chain (NfL), glial fibrillary acidic protein (GFAP), chitinase-3-like protein 1 (CHI3L1), and other protein assays are being developed as diagnostic or prognostic biomarkers in mul...

Online First: A Review on blood and CSF biomarkers for multiple sclerosis. Check it out: tinyurl.com/3v2s2ycr

Multimedia | Podcasts | In conversation with | The Lancet Neurology

New Podcast Alert! 🎵 Listen to Shiv Saidha talking about recent updates in the diagnosis of multiple sclerosis:

Promises, hopes, and dreams in Parkinson's disease research Since James Parkinson first described his eponymous disease, our knowledge of its pathophysiology has grown enormously. However, in clinical settings, many of the original concepts remain in use, and…

Online First: A Comment about the promises, hopes, and dreams of Parkinson's disease:

Cover of The Lancet's Sept 20, 2025 issue. Cover quote reads: "From 2010 to 2019, NCD mortality declined in four of every five countries in the world. These improvements were not as large as the preceding decade for most countries..."

Non-communicable diseases (NCDs) include cancers, cardiovascular diseases, diabetes, immune disorders, and more.

What progress has been made in NCDs since the early 2000s?

In our latest issue, a new global analysis explores this question: tinyurl.com/mszsxer8

Full issue in thread 🧵

Our October issue is out - featuring biomarkers for sudden unexpected death in epilepsy, developments in the diagnosis of multiple sclerosis, climate change & brain health and much more!

Check it out here: tinyurl.com/3z5u36e7

#Neurology #BrainHealth

The temporal order of genetic, environmental, and pathological risk factors in Parkinson's disease: paving the way to prevention Genetics research in Parkinson's disease has identified over 100 risk loci, yet translating these findings into understanding of disease mechanisms, clinical and pathological heterogeneity, and diseas...

The temporal order of genetic, environmental, and pathological risk factors in Parkinson's disease - read about it here: tinyurl.com/22uk86f8

The relevance of primary cilia in neurological disorders Primary cilia are ubiquitous organelles, which play essential roles in sensing and transducing cellular signals and in mediating key developmental pathways. Pathogenic variants in genes encoding for c...

If you haven't read it yet, we encourage you to check out this Review on the relevance of primary cilia in neurological disorders, featured in our most recent issue: tinyurl.com/2pdzssdv

#neurology #🧠

Offline: Help us, please “We all become monsters when History gives us the opportunity”, writes Olivier Norek in his novel about migrants and traffickers, Between Two Worlds. One of the malicious absurdities about political a...

"Who or what is responsible for a person risking their life to cross the Channel in a boat that is barely seaworthy?...All of us."

Richard Horton's latest Offline: Help us, please tinyurl.com/52zfck7b

Hans Berger and the EEG Hans Berger (1873–1941), a professor of psychiatry at the University of Jena, in Germany, who collaborated with the Nazi regime, is regarded as the father of EEG.1 As an adolescent, he borrowed a book...

Have you ever wondered who invented the EEG? You will find the answer in this short Focal Point: tinyurl.com/59e87nzn

Multimedia | Podcasts | In conversation with | The Lancet Neurology

👂Podcast alert!! Listen to our our conversation with Professor Michael Rafii about Down syndrome-related Alzheimer's disease here: tinyurl.com/59nvbxam

#DownSyndrome #AlzheimersDisease #Neurology