Marion Campbell

New fully funded PhD opportunity to come and work with me at the University of Glasgow exploring the role of data-driven interventions (audit and feedback) to improve environmental sustainability of the NHS. Deadline to apply: 12th Jan 2026.

Find out more here:
www.gla.ac.uk/colleges/mvl...

The 10 year follow-up results of the TOPKAT trial of total (TKR) vs partial (PKR) knee replacement are out! Similar clinical outcomes, but PKR more cost effective.
t.co/V4O7s6MvZe

Improving health by improving trials – applying behavioural science to improve the design and delivery of clinical trials. at University of Aberdeen on FindAPhD.com PhD Project - Improving health by improving trials – applying behavioural science to improve the design and delivery of clinical trials. at University of Aberdeen , listed on FindAPhD.com

One of my 2026 goals is to be more present on BlueSky! Another is to recruit a great candidate to this 4-yr PhD studentship with us at the Aberdeen Centre for Evaluation -applying behavioural science to the design and delivery of clinical trials. Please share. www.findaphd.com/phds/project...

Just 4 weeks to CCR Down Under 2025!

Join us to hear the results of 8 major critical care trials - in person or virtually

➡️ ImmunoSep
➡️ iRehab
➡️ CLIP II
➡️ ACTiVE
➡️ ARISE AFRICA
➡️ RSI
➡️ VITaCCA
➡️ ECMO REHAB

https://criticalcarereviews.com/meetings/ccr-down-under-2025

Beginning Nov 1924, studies on the effect of lighting on worker productivity were performed at the Western Electric Hawthorn Plant. These were the basis for the concept of the Hawthorne Effect 1/2

The work provides accessible definitions of the core elements of an estimand which will help aid understanding and should ease the use of the estimand framework across the range of stakeholders 8/8

A new paper by @suziecro.bsky.social and colleagues will help in this regard. Working with public partners, they developed a practical tool to explain the attributes of an estimand in an accessible manner 7/8
trialsjournal.biomedcentral.com/articles/10....

However, the technical language around estimands makes it hard to discuss the concept with patients and public (and indeed with many researchers and clinicians). 6/8

Kahan et al provide a useful introduction to the estimand approach and to the different terms/approaches used: 5/8
www.bmj.com/content/384/...

We may want to know how effective the treatment was in all patients allocated to it (this is called a “treatment policy” estimand strategy); or only in those patients who received it as planned (called a “principal stratum” approach) or some other variation. 4/8

“Intercurrent events” are post-randomisation events (eg discontinuation of treatment or treatment switching) and the estimand describes precisely how these events will be handled in the analysis. 3/8

An #estimand is effectively a more precise specification of the research question(s) and how the treatment effect is to be estimated (hence estimand). It also specifically describes how so called “intercurrent events” will be handled in the analysis. 2/8

The term #estimand is now part of the technical language of trials - but it remains a concept that many find hard to understand. Recent work has aimed to make the term more accessible to researchers, patients & public 1/8
#MethodologyMonday #127

The New England Journal of Medicine Deferring Arterial Catheterization in Critically Ill Patients with Shock A Research Summary based on Muller G et al. | 10.1056/NEJMoa2502136 | Published on October 29, 2025 Visual representations of the patients in the trial and the treatments they were assigned. Read the full Research Summary at NEJM.org.

In the EVERDAC trial involving patients with shock, results for death at day 28 indicated that management without early arterial catheter insertion was noninferior to early catheter insertion. Full trial results and Research Summary: nej.md/3LmOO0D 

#MedSky #PulmSky

The world’s largest and longest clinical trial in critical care, SuDDICU found a significant reduction in hospital-acquired infection in critically ill patients on mechanical ventilation, when given antibiotics preventatively before a new infection can develop.

European Society of Intensive Care Medicine Original Article | Oct 29, 2025 | NEJM.org Selective Decontamination of the Digestive Tract during Ventilation in the ICU Figure 2. Subgroup Analysis of In-Hospital Death at 90 Days.

In the SuDDICU trial of patients undergoing mechanical ventilation in the intensive care unit, selective decontamination of the digestive tract did not result in a lower incidence of in-hospital death than standard care alone. Full trial results: nej.md/4nhyeN8

#LIVES2025 | @esicm.bsky.social

Current Opportunities We have an iCASE studentship available to start for the 2025/2026 academic year, and applications to our fifth round of recruitment to our DTP to start in October 2026 are now also open. Please see…

📢 Interested in a PhD in clinical trials methodology? The Trials Methodology Research Partnership are advertising projects for PhDs starting Oct 2026, in statistics, health economics, epidemiology, social science, and more, hosted at one of 12 UK partner institutions.
mrctmrpdtp.com/current-oppo...

UK Statistics Authority Official statistics play a vital role in supporting society and the economy - informing government policymaking and evaluation, guiding economic and

Recruitment has begun for a new National Statistician (£200k). Important role as the strategic head of the UK statistical system. There is less operational work as there is now a Perm Sec for ONS. So they are seeking an ‘internationally recognised leader in statistics’
www.saxbam.com/appointment/...

📢 As one of the next round of TRMP PhD students (below) you could join me, Clare Robinson, @averoniki.bsky.social and @marionkcampbell.bsky.social to work on developing a typology of research outputs in trials methodology, based at @wiphcem.bsky.social. Details here: www.findaphd.com/phds/project...

It’s the UN #WorldStatisticsDay today! Perfect time to celebrate all the awesome statisticians who ensure robust data, design and analysis 😊

Bigirumurame et al also published a useful review of SMART trials and highlighted the need for accurate reporting 7/7
www.sciencedirect.com/science/arti...

Kidwell & Almirall wrote a short primer paper on the design 6/7
jamanetwork.com/journals/jam...

They have also be used in scenarios where one might begin with testing less costly or less intensive treatment strategies in the first phase and stepping up to testing more intensive strategies only if there is lack of response 5/7

The SMART design is typically more used in chronic conditions where response can be measured over time and different interventions/doses/sequences are available should individuals not respond to their first line allocated intervention 4/7

These designs are often seen as attractive to patients as the intervention they receive can be changed if they see no improvement 3/7

In a SMART trial each individual can undergo multiple randomisations. All get initially randomised in stage 1, but non-responders can then get randomised in stage 2 to further treatment options etc 2/7

One of the adaptive designs we are seeing more frequently is the Sequential Multiple Assignment Randomised Trial (or SMART trial) 1/7
#MethodologyMonday #126

CCR Down Under 2025 Critical Care Reviews Meeting Down Under - The Edge, Federation Square, Melbourne, December 9th - 10th, 2025

The 8th & final trial for CCR Down Under is ECMO Rehab

➡️100-patient RCT testing early mobilisation during ECMO to reduce 6-month disability
➡️Will mobilisation improve outcomes?

Join us in Melbourne, December 9/10
criticalcarereviews.com/meetings/ccr...

A special issue from Critical Care Resuscitation Journal honouring the legacy of Rinaldo Bellomo

Grab a coffee, sit back, read and smile.

Such an incredible person.

An uplifting tribute.

Kudos to the authors for sharing their experiences

www.sciencedirect.com/journal/crit...

Taken today 😊