Steven Julious

SDEC Latest project news

The first 12 months of our project evaluating same-day emergency care (SDEC) is nearly over.

You can read about how the project is progressing on our website:

sites.google.com/sheffield.ac...

@fohsheffield.bsky.social @scharr-msg.bsky.social @arc-yharc.bsky.social

#SDEC #NHS #NIHR

Summer Holidays Inhaler Use The most powerful, simple and trusted way to gather experience data. Start your journey to experience management and try a free account today.

Our PhD student is looking for children aged 5-16 with asthma in the UK to complete a survey to better understand inhaler use during the summer holidays among children and adolescents with asthma:
shef.qualtrics.com/jfe/form/SV_...

Please forward on.
@stevenjulious.bsky.social

Value-adaptive clinical trial designs for efficient delivery of publicly funded trials - a discussion of methods, case studies, opportunities and challenges - BMC Medical Research Methodology Background Value-adaptive designs for clinical trials are a novel set of emerging methods for delivering greater value for clinical research. There is increasing interest in using them within publicly...

Had a paper published with Laura Flight and @alan-brennan.bsky.social entitled

Value-adaptive clinical trial designs for efficient delivery of publicly funded trials - a discussion of methods, case studies, opportunities and challenges

doi.org/10.1186/s128...

Next Thursday, June 5th at 1pm (BST) we host our 4th webinar in our adverse event special series. Rayan Taher & Jenny Yiend will present their work on developing a process for assessing the safety of a digital mental health intervention & gaining regulatory approval. Register here: lnkd.in/eaW3MQrB

The protocol for MissionEB - a randomised, double-blinded, placebo-controlled, two-centre, crossover trial - a study to assess mesenchymal intravenous stromal cell infusions in children with recessive dystrophic epidermolysis bullosa has just published

doi.org/10.1136/bmjo...

A great talk at #SCT2025 by James Salsbury entitled

Assurance methods for designing a survival trial with delayed treatment effects

Attending an excellent talk by Nikki Totton at #SCT2025 entitled

Using benefit risk methods to adjust the non-inferiority margin based on treatment benefits

The paper can be found at

doi.org/10.1177/0962...

In clinical trials it is not only potential benefits that should be measured - it is crucially important that any potential #harms are also investigated 1/7
#MethodologyMonday #118

Had a paper published with Kelly Grant on the analysis of recurrent events in clinical trials

We recommend that the conditional frailty model be used for these data trials, including cluster randomised trials, to help explain changes in event risk over time, and assist clinical interpretation

Comparison of statistical methods for the analysis of patient-reported outcomes (PROs), particularly the Short-Form 36 (SF-36), in randomised controlled trials (RCTs) using standardised effect size (S... Background The Short-Form 36 (SF-36), a widely used patient-reported outcome (PRO), is a questionnaire completed by patients measuring health outcomes in clinical trials. The PRO scores can be discret...

Comparison of statistical methods for the analysis of patient-reported outcomes (PROs), particularly the Short-Form 36 (SF-36), in randomised controlled trials (RCTs) using standardised effect size (SES): an empirical analysis

hqlo.biomedcentral.com/articles/10....

Further development of a patient-reported outcome measure to assess the impact of oral secretion problems in people living with MND Objective: Oral secretion problems are common yet poorly managed in people living with MND (plwMND). A validated patient-reported outcome for measuring saliva symptoms in this patient group would f...

Second paper from the prosec3 study: Further development of a patient-reported outcome measure to assess the impact of oral secretion problems in people living with MND www.tandfonline.com/doi/full/10....

Estimating the minimum important difference in the ALSFRS-R-instrument in people living with MND Objective: The Amyotrophic Lateral Sclerosis Functional Rating Scale (ALSFRS-R) is a commonly used outcome measure in clinical trials for motor neuron disease (MND) therapies. As such, understandin...

New paper!! Estimating the minimum important difference in the ALSFRS-R-instrument in people living with MND www.tandfonline.com/doi/full/10....

Today's date

5-2-25

Is a palindrome

How often are children attending the emergency department for a non-urgent attendance? - ARC In this study, we aimed to explore differences in non-urgent attendances and urgent attendances in children to ED and determine which children present in this way and when.

New @arc-yharc.bsky.social blog by @beckiesimpson.bsky.social on "How often are children attending the emergency department for a non-urgent attendance?"

arc-yh.nihr.ac.uk/resources/bl...