Jay Gertz

Unanticipated mechanisms of covalent inhibitor and synthetic ligand cobinding to PPARγ Commonly used covalent PPARγ inhibitors weaken, but do not block, binding of other ligands via an allosteric mechanism where ligands clash with a covalent ligand-induced transcriptionally repressive s...

Our new story is out in eLife! From the editorial assessment: "This landmark study elucidates the intricate structural mechanisms by which both covalent and non-covalent synthetic ligands can co-occupy the binding pocket of the #nuclearreceptor transcription factor PPARγ..." doi.org/10.7554/eLif...

Looking forward to reconnecting at the International Adrenal Cancer Symposium in Houston! Excited to share new data with 2 talks & 2 posters on #WNT #senescence #androgens & #myeloid cells in #ACC. Hoping that someone in the #adrenal fan club might also appreciate our Halloween costume #hormones

New #lobular breast cancer study from Sikora Lab is up, after buzz re: PARP inhibitors at #ILCSymposium!

We think ILC-specific co-reg fxn of MDC1 allows ER:MDC1 to control endo response/resistance in ILC, at the cost of a DNA repair dysfunction that can be hit with PARPi.

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Transposable elements are co-opted as oncogenic regulatory elements by lineage-specific transcriptio... Abstract. Transposable elements hold regulatory functions that impact cell fate determination by controlling gene expression. However, little is known about the transcriptional machinery engaged at tr...

No better way to understand the genetic basis of cancer than to work on chromatin variants. Our latest work provides insights into the role of repetitive DNA sequences as regulatory elements across pluripotent, mature, and cancer cells (slight focus on prostate cancer). Enjoy!

Dynamite work from @profriggins.bsky.social for the first @biorxiv-cancer.bsky.social post!!! ER+ =/= ER+/HER2+ and the latter needs distinct attention when considering how tumors resist anti-estrogen therapy.

Estrogen Receptor Mutation Study Suggests Potential Treatments for Endometrial Cancers Huntsman Cancer Institute researchers studied estrogen receptor mutations and its connections to endometrial cancer. The findings led to the identification of potential personalized treatments for a c...

Since I just got over to Bluesky (Hi!), this story is a couple of days old. Nice writeup about Zannel Blanchard's final study in the lab: healthcare.utah.edu/huntsmancanc...