Induction of a mismatch repair deficient genotype by tailored chemical mutagenesis in experimental models of cancer Mismatch repair deficient (MMRd) tumors harbor thousands of somatic mutations enriched for insertion–deletion (indels) conferring high sensitivity to …

This is an important milestone: mutagenic drugs can increase TMB and induce a dMMR-like genetic profile, but do not improve response to immunotherapy in pMMR CRC patients. Some evidence of TIME remodelling, but likely not in the direction needed fro response... www.sciencedirect.com/science/arti...

Epithelial-to-mesenchymal transition (EMT) and cancer metastasis: the status quo of methods and experimental models 2025 - Molecular Cancer Epithelial-to-mesenchymal transition (EMT) is a crucial cellular process for embryogenesis, wound healing, and cancer progression. It involves a shift in cell interactions, leading to the detachment o...

link.springer.com/article/10.1...

Loss of colonic fidelity enables multilineage plasticity and metastasis - Nature The chromatin-remodelling enzyme ATRX and the transcription factor HNF4A are identified as pivotal regulators of colonic epithelial identity, with roles in metastasis in colorectal cancer.

Check out this elegant paper by Kevin Myant and team implicating ATRX mutations and loss of colon identity in #plasticity and #metastasis 👇@nature.com @edinburgh-uni.bsky.social‬
www.nature.com/articles/s41...

Evolutionary paths towards metastasis - Nature Reviews Cancer In this Perspective, Kamila Naxerova discusses how genetic analyses of primary tumours and matched metastases can distinguish between competing metastasis evolution models, arguing that further insights into human metastasis biology could be enabled by a framework that rigorously quantifies whether metastases descend from a nonrandom selection of primary tumour lineages.

🚨 PERSEPCTIVE

Naxerova explains how genetic analysis of primary tumors & metastases can distinguish competing metastasis models, arguing that quantifying whether metastasis occurs through nonrandom lineage selection could offer insights into metastasis biology.

📖 👇

PCSK9 drives sterol-dependent metastatic organ choice in pancreatic cancer - Nature PCSK9 regulates low density lipoprotein-cholesterol import and determines organ preference of metastatic pancreatic ductal adenocarcinoma, with PCSK9-low cells metastasizing to the liver and PCSK9-hig...

new out in Nature today www.nature.com/articles/s41...

Fishing for melanoma metastasis-initiating cells in lymph nodes Nature Cancer - The complex nature of metastasis-initiating cells (MICs) has long hindered our understanding of how cancer spreads and how to prevent it. A study now identifies a potential MIC...

rdcu.be/emi9N
Fishing for Metastasis Initiating Cells (MICs): we summarize here a heroic effort from Christoph Klein and Melanie Werner-Klein labs, which describes a MIC population in lymph nodes and how these cells evade immune attack. #metastasis #melanoma #extracellularvesicles #cancerprevention

#AACR25

The size of the plenary hall is always inspiring. So many cancer researchers in one place!

Fantastic talk by @karunamdphd.bsky.social! A comprehensive study investigating microenvironmental impact on young onset colorectal cancer.

Ready to learn about dormancy at #AACR25

Tumor metabolism is always a tough topic but the speakers at the microenvironment and metabolism session at #AACR25 are doing a great job making it accessible.

While many nutrients are absent in the area around the tumor. Some metabolites are far more abundant! How are tumors using these instead?

Fantastic first session at #AACR25 on non-genetic drivers of metastasis!

While genetic drivers are important in establishing fitness, it is clear that they are not sufficient to lead to metastasis by themselves.

Transcription factor networks disproportionately enrich for heritability of blood cell phenotypes Most phenotype-associated genetic variants map to noncoding regulatory regions of the human genome, but their mechanisms remain elusive in most cases. We developed a highly efficient strategy, Perturb...

Out today in @science.org!
What if you could chart cells' regulatory programs at unprecedented resolution?
In my work with Jorge Martin-Rufino from the @bloodgenes.bsky.social lab, we dissect the genome’s control circuits and find where key genetic variation hides
bit.ly/3YhBMoO

Regulation of metastatic organotropism Metastasis is responsible for most cancer-related deaths. Different cancers have their own preferential sites of metastases, a phenomenon termed metastatic organotropism. The mechanisms underlying org...

Super nice review on metastasis organo-tropism⬇️ the process where tumor cells preferentially spread to specific distant organs, and represents a critical aspect of cancer biology with profound implications for patient outcomes. #CDH1
www.cell.com/trends/cance...

Figure 1 TFBomics of the E11.5 mouse embryo. (A) Schematic overview of the experimental design, detailing the tissues dissected from E11.5 JAX/Swiss mice and the targets profiled in each tissue using C&R LoV-U. (B) Left: Clustering of data according to Spearman's correlation. Black boxes highlight higher correlation or clustering according to the profiled factor, whereas red boxes highlight this between factors within the same tissue. IgG negative controls are highlighted in a gray box. Right: Overall data patterns shown by PCA. PC1 (58.7% of variance) separated some samples by the target factor (ellipses shaded by factor color code), while PC2 (9.7% of variance) typically separates the liver (marked with stars) from other tissues.

Construction of an atlas of transcription factor binding during mouse development identifies popular regulatory regions

Read this Techniques & Resources Article by @annanordin.bsky.social @gianlucazamba.bsky.social @claudiocantu81.bsky.social & co.: doi.org/10.1242/dev....

Decoding gene regulation with CRISPR perturbations - Nature Biotechnology Two CRISPR tools for combinatorial genetic perturbations reveal gene regulatory networks.

Two CRISPR tools for combinatorial genetic perturbations reveal gene regulatory networks #NBTNV go.nature.com/3WOWHjb
rdcu.be/dItUy

Human-correlated genetic models identify precision therapy for liver cancer - Nature As proof of principle, an analysis using a suite of human-aligned immunocompetent mouse models of hepatocellular carcinoma identifies a promising therapeutic candidate, cladribine, which acts in ...

Out in Nature today: A suite of GEMMs recapitulating the spectrum of human Liver Cancer phenotypes, showing once again that a little MYC goes a long way
www.nature.com/articles/s41...

Cancer-Associated Fibroblasts Serve as Decoys to Suppress NK Cell Anti-Cancer Cytotoxicity in Breast Cancer - by Aviad Ben Shmuel, Yael Gruper, Coral Halperin, Ruth Scherz-Shouval and colleagues doi.org/10.1158/2159...

Ten simple rules for writing a response to reviewers

journals.plos.org/ploscompbiol...

Long-range enhancer-controlled genes are hypersensitive to regulatory factor perturbations
www.cell.com/cell-genomic...

Targeting Colorectal Cancer Liver Metastasis Through Repurposing Metabolic and Immune Inhibitors : A Theoretical Study https://www.biorxiv.org/content/10.1101/2025.02.12.637833v1

Cytokines in cancer Kureshi and Dougan discuss the roles of cytokines in the tumor microenvironment. Although there is a sophisticated understanding of cytokine networks, therapeutically targeting cytokine pathways in ca...

Cytokines in cancer: Cancer Cell

www.cell.com/cancer-cell/...

Metastatic patterns stratify patients with pancreatic cancer - Nature Cancer Patients with lung-metastatic pancreatic ductal adenocarcinoma survive longer than those with liver metastases. A study now leverages real-world data to identify distinct molecular and immune profiles...

Metastatic patterns stratify patients with pancreatic cancer ⁦‪@NatureCancer‬⁩

www.nature.com/articles/s43...

The AAVantages of AAV in CRISPR Screens Learn about the advantages of using AAV as a delivery method for CRISPR screens.

The in vivo option — why you should consider AAV for your next CRISPR screen. Find out in our latest blog post!

blog.addgene.org/aav...

CRISPR screening reveals SYCP3 as a key driver of metastasis in prostate cancer https://www.biorxiv.org/content/10.1101/2025.01.30.629925v1

Diet links gut chemistry with cancer risk in C57Bl/6 mice and human colorectal cancer patients https://www.biorxiv.org/content/10.1101/2025.01.27.635083v1

2 weeks until the deadline for our Diversity in Cancer Research summer internship program at Georgetown Lombardi. Amid the fear and chaos of this week, I want to be clear - we are committed to this program. Our non-govt funders are committed to this program. We're not going anywhere 🧪🧬👩‍🔬

Thank you for the opportunity to present our work and organizing a fantastic meeting!

In this review, Kudelka et al. examine the unifying cellular and molecular principles that contribute to the development and progression of squamous cell carcinomas at different anatomical sites. #OpenAccess

Learn more here:
➡️ tinyurl.com/gd351990

Dealing With Being a Tumor Cell

How do cancer cells adapt to the stress of being cancer cells, with the constant stream of mutant and misfolded proteins? There’s more than one strategy, and therapeutically you’d like to know which is being used: