Nicolas Malaquin, PhD

@icsasenescence.bsky.social #icsarome2025. What a great meeting!! Thank you again for the organization, all the presentations and discussions!

Thanks for this fantastic meeting! See you next year

Félicitations à toute l’équipe!

Boosted by grant, Montreal research seeks to prevent dormant cancer cells from reawakening Montreal researchers who are studying how ovarian cancer cells can reawaken after going dormant are ultimately trying to prevent cancer from coming back after treatment. The project, led by Dr. Franci...

Apprenez-en davantage sur les travaux de recherche de Francis Rodier 👇

Guidelines for minimal information on cellular senescence experimentation in vivo This primer introduces the “minimal information on cellular senescence experimentation in vivo” (MICSE) guidelines, which aim to address the challenges in identifying and characterizing senescent cells. It provides an overview of senescence markers in various systems and offers a practical toolset to enhance our understanding of cellular senescence in vivo.

"Guidelines for minimal information on cellular senescence experimentation in vivo" The MICSE guidelines were initiated and coordinated by Mikolaj Ogrodnik, Heinz Redl, Nadja Ring (LBG SHoW), Johannes Grillari (LBI Trauma & @bokuvienna.bsky.social) & Marco Demaria (ICSA) www.cell.com/cell/fulltex...

Chromosome mis-segregation triggers cell cycle arrest through a mechanosensitive nuclear envelope checkpoint - Nature Cell Biology Hervé, Scelfo et al. show that chromosome mis-segregation induces mTORC2- and ATR-mediated p53 activation through a mechanosensitive checkpoint at the nuclear envelope triggered by altered heterochrom...

Showcasing this exciting paper from our good friends Fachinetti lab @institutcurie.bsky.social. #Centromere inactivation triggers #senescence: mis-segregated chromosomes deform the nuclear envelope and activate TORC2-ATR. We helped with #cGAS and some key suggestions.
doi.org/10.1038/s415...

Senescent cell identification SenCID

#MachineLearning
52 transcriptomic datasets; 30 cell types▶️6 #Senescence modules

Single-cell senescence trajectories in multi-tissue Aging & Diseases

SMCs "have high basal senescence score"😬

@cp-cellmetabolism.bsky.social 2024
www.cell.com/cell-metabol...

Immune evasion through mitochondrial transfer in the tumour microenvironment Nature - Mitochondria with mutations in their DNA from cancer cells can be transferred to T cells in the tumour microenvironment, which leads to T cell dysfunction and impaired...

rdcu.be/d7Q3h

Radiothérapie : des mécanismes secrets régulent son efficacité Les années lumière | Ça fait plus de 70 ans qu’on utilise la radiothérapie pour traiter des tumeurs cancéreuses. Malgré tout, la méthode conserve encore certains mystères. Des scientifiques australien...

À ÉCOUTER | Dans la dernière émission des Années Lumières sur Radio Canada, Francis Rodier, chercheur régulier au CRCHUM s’exprime sur la radiothérapie, ses différents mécanismes et ses nouveautés.

Pour en savoir plus : bit.ly/4apwuMW