Fergus O'Farrell

📢Fabulous new paper from @tspiresjones.bsky.social, @clairedurrant1.bsky.social & team describes new mechanisms in Progressive Supranuclear Palsy, suggesting that targeting tau in synapses is a promising approach for future treatments.

Full paper➡️www.nature.com/articles/s41593-025-01992-5 🧠

Delighted to share our paper examining synaptic tau in PSP. Many thanks to @robertmcgeachan.bsky.social @clairedurrant1.bsky.social and our many collaborators and funders. And extra special thanks to tissue donors who make this work possible.

Medium rare. Vanishingly common. Not rare but not not uncommon.

My amazing pal Gene Koh strikes again! #InDel #CancerGenomics #MutationalSignatures @naturegenet.bsky.social

Prescient urban planners installed this lovely sculpture of the Down Jones index in Cambridge 😌.
#stockmarketcrash

Today is the 17th BDIAP Approach to Cut-Up Study Day! The study day provides an opportunity for attendees to learn more about how to tackle some of the complex specimens that they may encounter in their departments.
#PathologyStudyDay #CutUpPathology #MedicalTraining #Pathologist #MedicalEducation

The 10th BDIAP Molecular Pathology Study Day has started!

#PathologyStudyDay #CutUpPathology #MedicalTraining #Pathologist #MedicalEducation #HealthcareProfessionals #StudyDay #BookNow
#pathology #histopathology #pathologyeducation #biomedicalscientist #pathologists

Mechanisms of astrocyte aging in reactivity and disease - Molecular Neurodegeneration Normal aging alters brain functions and phenotypes. However, it is not well understood how astrocytes are impacted by aging, nor how they contribute to neuronal dysfunction and disease risk as organis...

Excited to share our review on astrocyte aging, out today! Hopefully the only Friday surprises this week are Liddelow lab publications! 🧪 #neuroskyence @liddelowsa.bsky.social

Dr Hunter was sassy 😌😂

Brain pericytes and perivascular fibroblasts are stromal progenitors with dual functions in cerebrovascular regeneration after stroke - Nature Neuroscience Bernier, Hefendehl et al. describe a stromal progenitor cell population consisting of pericytes, venular smooth muscle cells and perivascular fibroblasts in the adult brain that modify their function ...

Great new work by Brian MacVicar's team, showing that pericytes and perivascular fibroblasts are distinct subpopulations of stromal progenitor cells in the adult brain that coordinate revascularization and scar formation after injury. #cerebrovascular #stroke #pericytes

This is how post-mortems should be documented 😉. From: Descriptive catalogue of the pathological series in the Hunterian Museum of the Royal College of Surgeons of England (1966) #PathSky

"The drowsy stillness of the afternoon was shattered by what sounded to his strained senses like G.K. Chesterton falling on a sheet of tin." P. G. Wodehouse

Office desk without any personal items or decor

Today, along with 2,000 other NIH employees, I had to clear out my office 😭

It was truly the honor of my life to work with such incredibly passionate people focused on improving human health. I’ve never experienced a more positive culture where *everyone* cared about their job and serving others.

@physoc.bsky.social has a starter pack of physiologists. Hooray!! go.bsky.app/2KU1XD6

Microglia as hunters or gatherers of brain synapses - Nature Neuroscience How microglia sculpt brain circuits is not clear. Here, the authors propose that their contribution to synapse removal may occur by severing synapses (culling) or collecting synapses shed off by neuro...

A Perspective from @sierralab.bsky.social on #microglia as hunters or gatherers of brain synapses

www.nature.com/articles/s41...

2025 resolution: leave the pit that is Cambridge

Waking out of my sleep on a sudden, I did with my elbow hit my wife a great blow over her face and nose, which waked her with pain, at which I was sorry, and to sleep again.

Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order. No explanations, no reviews, just covers.
#Books #BookSky #BookChallenge

Day 13 (ish)

Cancer Ward, Aleksandr Solzhenitsyn

My neuroscience Christmas decorations c. 2013

Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order. No explanations, no reviews, just covers.
#Books #BookSky #BookChallenge

Day 12

War and Peace, Leo Tolstoy

Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order. No explanations, no reviews, just covers.
#Books #BookSky #BookChallenge

Day 11

Vanity Fair, William Makepeace Thackeray

Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order. No explanations, no reviews, just covers.
#Books #BookSky #BookChallenge

Day 10

Middlemarch, George Eliot (Mary Ann Evans)

Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order. No explanations, no reviews, just covers.
#Books #BookSky #BookChallenge

Day 9

A Manual for Cleaning Women, Lucia Berlin

Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order. No explanations, no reviews, just covers.
#Books #BookSky #BookChallenge

Day 8

The Prime of Miss Jean Brodie, Muriel Spark

Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order. No explanations, no reviews, just covers.
#Books #BookSky #BookChallenge

Day 7

The Grapes of Wrath, John Steinbeck

Spatial transcriptomic clocks reveal cell proximity effects in brain ageing Nature - A spatially resolved single-cell transcriptomics map of the mouse brain at different ages reveals signatures of ageing, rejuvenation and disease, including ageing effects associated with T...

Thrilled to see this paper out!! 🧪

Spatial transcriptomics of brain aging and 'spatial aging clocks' identify cells that have pro-aging or pro-rejuvenating effects on their neighbors!

Huge CONGRATS to Eric Sun and all authors! Fantastic collaboration with @jameszou.bsky.social!

rdcu.be/d33uQ 🧵

I'm excited to share another project we've been working on: The Transmitter's first book, which includes some of our favorite essays from our first ~9 months. Download a copy here: www.thetransmitter.org/transmitter-...

Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order. No explanations, no reviews, just covers.
#Books #BookSky #BookChallenge

Day 6

Bleak House, Charles Dickens

Suitably miniature mince pies for the microscopist in your life.
?asteroid bodies
#pathsky

We're so excited to join the party over here! Follow this account to learn more about the latest papers published in Nature Neuroscience!