Niveda Shekar

Rise in Kidney Disease Tied to Other Chronic Conditions, Study Finds Rates of the disease have been rising for decades, driven in part by diabetes and high blood pressure.

The number of adults with chronic kidney disease is growing, according to a new study. The disease was the ninth leading cause of death worldwide in 2023, up from the 27th leading cause in 1990.

Last week we celebrated our graduating fellows! We are so proud of you and cannot wait to see your careers flourish, congratulations! 🎓🥳✨

Xenotransplantation: Current Understanding of the Mechanism ... : Journal of the American Society of Nephrology this significant unmet need. Indeed, if there is a limitless supply of organs, many more patients who do not meet the current criteria for transplant eligibility could also be considered as candidates...

An excellent review of kidney xenotransplantation written by the our transplant team! Check it out 🐷https://journals.lww.com/jasn/abstract/9900/xenotransplantation__current_understanding_of_the.632.aspx

Findings by Jennifer S. Pollock and team indicate that time-restricted feeding may be an effective intervention for improving cardiovascular and kidney health in obese mice. https://buff.ly/3EWFZYc

Protein restriction in CKD: an outdated strategy in the modern era - PubMed Chronic kidney disease (CKD) management has traditionally emphasized dietary protein restriction to slow disease progression and delay end-stage renal disease (ESRD). However, evidence from trials que...

Our last #ISNWCN debate on protein restriction in CKD is now published - #OpenAccess

pubmed.ncbi.nlm.nih.gov/39933007/

with @kidneyboy.bsky.social and Abdullah Bawazir, OttawaRenal fellow

#NephSky

FDA approves pig organ transplant trials for patients with kidney failure The first clinical trials using organs from genetically modified pigs offer hope to patients with kidney failure, who face a long wait for human organ transplants.

The Food and Drug Administration has given two biotechnology companies approval for clinical trials that will transplant organs from genetically modified pigs into patients with kidney failure, an experimental but potentially groundbreaking innovation.

Great imaging, not a difficult diagnosis acrobat.adobe.com/id/urn:aaid:... @nyunephro.bsky.social @saltnshekar.bsky.social

Figure 1. eGFR 24 months pre- and post-SGLT2i. eGFR ml/min/1.73m2 is shown 24 months pre- and 24 months post-SGLT2 initiation.

#SGLT2 inhibitors are safe and efficacious in renal #transplant recipients with #diabetes

DOI: doi.org/10.1177/2054...

@csnscn.bsky.social @cjkhd.bsky.social @UnityHealthTO

Scientific advancements aside, this is economically irresponsible

Every $1 spent by NIH generates $2.46

For example, in 2023, $47B in NIH spending generated ~$93B

Halting NIH spending will LOSE the US a lot of money (and talent)

Figure 3 Mean change in the values of (a) eGFRcr-cys, (b) eGFRcys, and (c) eGFRcr during the whole study period in groups 1 and 2 from 0 to 12 months using linear mixed models. The model included fixed effects such as group (1 or 2), period (0–12 months), and 0-month eGFR as well as an interaction term, i.e., period × group. Abbreviations: DAPA, dapagliflozin; eGFR, estimated glomerular filtration rate; cr, creatinine; cys, cystatin C.

A small N of 27 trial of flozins in PKD!

Already on Tolvaptan

www.kireports.org/article/S246... in @kireports.bsky.social

Hard to believe such dramatic results. But building the case for a proper RCT to be finally done!

SZC With Dialysate Potassium Can Reduce Arrhythmias in Hemodialysis Patients With Hyperkalemia | Docwire News A study examined whether the use of potassium binder sodium zirconium cyclosilicate (SZC) with dialysate potassium could reduce postdialysis heart arrhythmias.

A study examined whether the use of sodium zirconium cyclosilicate combined with dialysate potassium could reduce the incidence of postdialysis atrial fibrillation and clinically significant cardiac arrhythmias. #potassium #hemodialysis #cardiovascular

Giving a kidney to a stranger? Researchers call it 'extraordinary altruism' Only about 300 to 400 people a year give a kidney to someone they never met. It's an act of generosity so unusual, a neuroscientist studies the people who do this.

Only about 300 to 400 people a year give a kidney to someone they never met. It's an act of generosity so unusual, a neuroscientist studies the people who do this.

A transplanted pig kidney offers a grandmother hope for life without dialysis The patient was in kidney failure and her immune system would reject a human organ. Scientists hope genetically modified pig organs prove safe and will alleviate the organ shortage and save lives.

What an exciting time! 🐷✨ @nyunephro.bsky.social
www.npr.org/sections/sho...

We are thrilled to be on BlueSky and more excited to introduce our 2025-2027 incoming nephrology fellows! Welcome and congratulations, we look forward to meeting you in July! ✨🎉🥳 #FellowshipMatch2024 @weddellite.bsky.social

Treating Metabolic Acidosis for CKD Progression? Need for... : Clinical Journal of the American Society of Nephrology An abstract is unavailable. This article is available as a PDF only.

Treating Metabolic Acidosis for CKD Progression? Need for Need for Higher Quality Data

journals.lww.com/cjasn/citati...

Such a ubiquitous medication!

SGLT2 Inhibitors Might Lower Stone Risk Better Than Other Type 2 Diabetes Drugs SGLT2 inhibitors treat type 2 diabetes and might also help prevent kidney stones.

www.renalandurologynews.com/news/sglt2-i... @amyaimei.bsky.social #nephsky @saltnshekar.bsky.social

🆕 Antibody identified in podocytopathies 🫘after Anti nephrin Ab⭐

Anti Slit diaphragm Ab ‼️‼️‼️

The heterogeneity in response to immunosuppression is understandable now!
#Nephsky