Maini Lab @IIT UCL

congratulations Alice!

Our paper is out! Check out this beautiful story where we uncovered that the costimulatory molecule ICOS is detrimental for PD-1+ CD8 T cells.
Sustained ICOS signaling reduces memory-like features of progenitor exhausted CD8 T cells in chronic viral infection and liver cancer.

Rapid discovery of monoclonal antibodies by microfluidics-enabled FACS of single pathogen-specific antibody-secreting cells - Nature Biotechnology Antigen-specific antibodies secreted by plasma cells are rapidly identified using microfluidics and fluorescence-activated cell sorting (FACS).

Antigen-specific antibodies secreted by plasma cells are rapidly identified using microfluidics and fluorescence-activated cell sorting (FACS) go.nature.com/4dHLaHB
rdcu.be/etg8W

1/ 🚨 Hot off the press in Nature Immunology: CD4⁺ T cells can license Kupffer cells to rescue dysfunctional CD8⁺ T cells in the liver. Hepatitis B virus (HBV) infection is just the proving ground—this is a paradigm shift in tissue immunity. www.nature.com/articles/s41... 🧵(1/11)

Congratulations Vale, Cris, Matteo and all -great to see this out!

Don’t miss this great scientific meeting and HBV family reunion

This will be an interesting project and great new lab-check out this post-doc position with our colleague Doug Fink @IIT UCL

We are very proud to bring you a highly requested new type of event this year 🙌:

an ECR Careers Meeting 🤩

Join us Thurs. 13th March at the UCL IIT/Pears Building (Hampstead, London)

🚨Registration is FREE! Follow this link to register NOW! www.immunology.org/events/bsi-l...

For more details👇

Human-correlated genetic models identify precision therapy for liver cancer - Nature As proof of principle, an analysis using a suite of human-aligned immunocompetent mouse models of hepatocellular carcinoma identifies a promising therapeutic candidate, cladribine, which acts in a highly effective subtype-specific manner in combination with standard-of-care therapy.

Nature research paper: Human-correlated genetic models identify precision therapy for liver cancer

https://go.nature.com/41qNkbs

#hiring #postdoc
We are looking for a postdoc to work on anti-tumor gamma delta T cells in breast cancer metastasis mouse models. Apply here:
www.gla.ac.uk/explore/jobs...

Don’t forget to apply by 18th Feb for our 3 year Wellcome post-doc to join our great team working on HBV tissue immunity! www.linkedin.com/jobs/view/re...

Large group of people celebrating Chinese new year. The photo includes some one dressed in a red traditional Lion Dance costume too.

Many of the extended 4th floor IIT family went out to celebrate Chinese New Year #YearOfTheSnake 🐍 - such a lovely evening 😊

Looking for an #immunology #postdoc?
Then I *THOROUGHLY RECOMMEND* @mainilab.bsky.social

Incredibly supportive PI & environment
Cutting-edge science🧪 (dissecting hepatic #immunity in people w/ #hepatitisB & #cancer)
Fab team & collabs
Great institute

APPLY NOW: www.linkedin.com/jobs/view/re...

Any post-docs interested in dissecting host-pathogen interactions in tissue- check out our advert on LinkedIn to join us @UCL IIT Pears Building! #immunosky

Open call for new research groups @pasteur.fr in Paris lots of immunology themes welcome #immunosky #IDsky #Scisky 🧪🥼🔬 get in touch if you have questions

A lipid made by tumour cells reprograms immune cells Insights into how cancer cells become unresponsive to therapy.

Thrilled to share that our paper www.nature.com/articles/s41... is featured in a fantastic Nature News & Views piece by thomastueting.bsky.social! 🎉 Grateful for the spotlight on our research and its impact on understanding cancer immunology. www.nature.com/articles/d41... 👀👉 rdcu.be/d3cRz

An ultra-early, transient interferon-associated innate immune response associates with protection from SARS-CoV-2 infection despite exposure Our interferon-associated signature of early SARS-CoV-2 infection characterises a subgroup of exposed, uninfected contacts in three independent cohorts who may have successfully aborted infection prior to induction of adaptive immunity. The earlier transient upregulation of signature genes in PCR-negative compared to PCR-positive CHIM volunteers suggests that ultra-early interferon-associated innate immune responses correlate with, and may contribute to, protection against SARS-CoV-2 infection.

Why do some people, despite SARS-CoV-2 exposure, not develop an infection?
An ultra-early interferon response blocks Covid
www.thelancet.com/journals/ebi...
adds to protection from pre-existing, cross-reactive T cells in some people

EastBio: Long-range consequences of intestinal helminth infection. at University of Edinburgh on FindAPhD.com PhD Project - EastBio: Long-range consequences of intestinal helminth infection. at University of Edinburgh, listed on FindAPhD.com

An excellent PhD opportunity available in our team: long-range consequences of parasite infection, gut-lung communication and helminth-viral co-infection. Part of the EastBio training programme. Closing date 17th January. Please get in touch!
www.findaphd.com/phds/project...

Thanks all for another great year's team work @UCL IIT and for all those fun Secret Santa pressies that kept us guessing!
#immunosky

Speaker line up for #EMBOTissueImmunity to take place in Basel 🇨🇭 26-29 August 2025. Come join @maurogaya.bsky.social and I for some fantastic #immunology along the Rhine! Please share this invitation - we hope you will join us. Registrations will be open soon.

SARS-CoV-2 human challenge reveals biomarkers that discriminate early and late phases of respiratory viral infections - Nature Communications It’s not always clear whether blood biomarkers are differentially expressed in the time course of viral infections. In this SARS-CoV-2 human challenge study, the authors identify distinct single-gene ...

Also out now.. after peer review, our analysis of blood transcriptional biomarkers of acute respiratory viral infection leveraging the SARS-CoV-2 human challenge model: www.nature.com/articles/s41...

Circulating tumor-reactive KIR+CD8+ T cells suppress anti-tumor immunity in patients with melanoma - Nature Immunology Tumor-antigen-specific CD8+ T cells are generally thought to help fight against cancer, but here the authors identify a subpopulation of CD8+ T cells that are associated with a poor clinical outcome i...

More #evidence for the existence of #CD8 #Regulatory #Tcells www.nature.com/articles/s41... Check our previous paper also> #KIR+CD8+ #T cells suppress pathogenic T cells and are active in autoimmune diseases and COVID-19 | Science www.science.org/doi/10.1126/...

T-Switch: A specificity-based engineering platform for developing safe and effective T cell therapeutics Abdelfattah et al. developed an engineering platform (T-Switch) for the creation, modification, and high-throughput profiling of T cell receptors (TCRs) to desired targets, particularly self-antigens....

Engineering T cells with capability for a switch in specificity
www.cell.com/immunity/ful... for better homing agents, to improve safety and efficacy vs cancer and other emerging T cell interventions

Yes please

A vaccine platform targeting lung-resident memory CD4+ T-cells provides protection against heterosubtypic influenza infections in mice and ferrets
www.nature.com/articles/s41...

Our top-rated #bioinformatics #training course 'Omic data analysis and visualisation using R' starts in less than 2 weeks (9 Dec)

Perfect for those who want to gain new #DataAnalysis and #omics skills 🤩

Don't miss out! Book your place now 👉 bit.ly/4gXvxOF

Please add us too- thanks!

The diverse roles of neutrophils from protection to pathogenesis Nature Immunology - In this Review, Herro and Grimes summarize the most recent key findings surrounding protective versus pathogenic functions of neutrophils, elaborating on phenotype-specific...

Are neutrophils "good" or "bad"?
Rana Herro reviews the current literature here: rdcu.be/d0Rt7

Slowly but surely the migration from 🐦➡️🦋 is happening and those from our Institute are moving too ❤️

You can find those working at the UCL institute for immunity and transplantation (aka the 🍐🍐 building, if you know, you know) here: go.bsky.app/84owGLt

#immunosky #academicsky 🧪

Congratulations Gabriele!