Allen M. Orville

Serial femtosecond crystallography reveals protein dynamics in real time Proteins are constantly moving, but our structures of them are static. Clare Sansom talks to the researchers using free-electron lasers to make time-resolved structures

Serial femtosecond crystallography reveals protein dynamics in real time
www.chemistryworld.com/features/ser...

Deafening Quiet from the Scientific Establishment Leaders are underestimating the risks of not fighting back

I am really glad that @jeremymberg.bsky.social wrote this. Everybody who cares about science, and about knowledge generation and civil society generally, should read and share with their favorite administrator.

Deafening Quiet from the Scientific Establishment
open.substack.com/pub/donmoyni...

I hope so, and anticipate that more planning in advance is needed to help bring these kinds of discussions to the forefront.

The grc prevented me from showing this at a recent meeting. People were intrigued. We still had some discussions around coffee, meals, and at the bar, about the elephant in the room issue ... We missed a chance for real discussion in an open session. #noKings, #HandsOff, #standUpforScience,

Serial-femtosecond crystallography reveals how a phytochrome variant couples chromophore and protein structural changes Serial-femtosecond x-ray crystallography reveals coupling of chromophore and protein structural changes in a phytochrome.

A recent publication for some of our time-resolved crystallography work at #XFELs, #LCLS, #SACLA
www.science.org/doi/10.1126/...

Protest poster v 2.0
#Protest #HandsOFF #expat #Resist #Democracy #fiftyfiftyone #5051movement #DueProcess #NoKings

#Hands-OFF

I used my last permanent address in NY to cast an absentee ballot in the 2024 national election. It still required due diligence, was a closer result, and in a swing district. Your vote does matter! Your voice matters! Resist all USA voter suppression scams!
#no_SAFE-Act #HandsOff

USA citizen expat from So. Dakota. Secured a SD driver's license in 2021 w/ voting privileges. 21 March 2023, "Gov. Knome" changed SD voting rules, eliminating my voting option. The data:
> 74,000 fewer absentee ballots (2024 vs 2020)
Dem. ballots fell 47%
Rep. ballots fell 25%
#vote #expat #resist

Hands Off! Londoners Fight Back (London, UK) · Hands Off Donald Trump and Elon Musk think everything belongs to them. Londoners are fighting back! US citizens, Canadians, Brits, and people from all over the globe who've found a home in London are standing ...

Every little helps ... even from expats
#expats
www.mobilize.us/handsoff/eve...

From Nobel buzz to hiring halt: Trump funding cuts hobble UW protein design startup machine The hiring freeze at the University of Washington threatens the research pipeline surging in the lab of Nobel Prize winner David Baker.

Votes DO matter!
#science #expats #HHS
www.geekwire.com/2025/from-no...

75% of US scientists who answered Nature poll consider leaving More than 1,600 readers answered our poll; many said they were looking for jobs in Europe and Canada.

Well, I'm not surprised at all... It's been a good move for me!
#expat #science
www.nature.com/articles/d41...

The truth is incontrovertible. Malice may attack it, ignorance may deride it, but in the end, there it is.

Winston Churchill

Exclusive: NIH to cut grants for COVID research, documents reveal Studies on climate change and South Africa are also on the latest list of grants to be terminated, according to updated documents obtained by Nature.

HHS Cuts ==> w/o NIH funding, there will much less new knowledge ...
@altnih4science.bsky.social

www.nature.com/articles/d41...

"Figure 1. SARS-CoV-2 Genome and Proteome Organization. Near complete 3D knowledge of the SARS-CoV-2 proteome derives from >4600 SARS-CoV-2 related PDB structures ... , plus computed structure models based on SARS-CoV-1 related structures archived in the PDB."

A very nice review. A large part of this R&D is/was supported by NIH funding ... Knowledge is POWER.
@altnih4science.bsky.social
#Science #HHS #NIH #COVID

Burley, S. K. Curr Opin Struct Biol 90, 102954, doi:10.1016/j.sbi.2024.102954 (2025).

www.sciencedirect.com/science/arti...

"It is science and innovation that make us healthy, wealthy and wise" says Sir Adrian Smith PRS in @thetimes.com Thunderer column this morning. "Yet, in the very bastions of scientific excellence in the US and elsewhere, we are in danger of abandoning the principles that enable science to flourish."

Behind every great woman in science, there’s another great woman in science To mark International Women’s Day on 8 March, six award-winning female scientists highlight women who have inspired them by pushing innovative research and creating opportunities for others.

I'm a big fan of a diverse work force - it's better for everyone, and for science too!

www.nature.com/articles/d41...

Firefly Blue Ghost Mission 1 Lunar Landing With a suite of NASA science and technology on board, Firefly Aerospace is targeting no earlier than 3:34 a.m. EST Sunday, March 2, to land their Blue Ghost

congrats to Firefly -- just landed on the moon

plus.nasa.gov/scheduled-vi...

A Direct Hit (Ep 130) Podcast Episode · Big Biology · 02/21/2025 · 59m

a good discussion with Holden Thorp

podcasts.apple.com/us/podcast/a...

The Fork in the Road | Mark Greif There may well be normalcy again. But it lies on the other side—not in accommodation to this malevolent insanity, run by lackeys and toads. The risk of overreaction is trivial compared to the risks of...

An interesting read ...

www.nplusonemag.com/online-only/...

YouTube video by The Ezra Klein Show Don't Believe Him | The Ezra Klein Show

www.youtube.com/watch?v=K8QL...

Memory-Holing Jan. 6: What Happens When You Try to Make History Vanish? The Trump administration’s decision to delete a DOJ database of cases against Capitol riot defendants places those who seek to preserve the historical record in direct opposition to their own governme...

www.propublica.org/article/janu...

We need large scale facilities to enable a very broad array of research across the UK and globally too... please cut funding for war instead, and support science for peaceful purposes!
www.researchprofessionalnews.com/rr-news-uk-r...

NIH In Your State - United For Medical Research Select a state on the map to see the impact of NIH funding across America.

www.unitedformedicalresearch.org/nih-in-your-...