Jacques Izard

Microbiome and metabolome association network analysis identifies Clostridium_sensu_stricto_1 as a stronger keystone genus candidate than Bifidobacterium in the gut of common marmosets | mSystems Previous studies have identified significant individuality within the gut microbiome of common marmosets. The reasons for this inter-subject variability and how it relates to health in captivity are p...

Microbiome and metabolome data decipher the keystone organism(s) in the digestive tract of primate #microbiome #metabolome #gutmicrobiome #GutMicrobes #microsky doi.org/10.1128/msys...

My lab is looking for a postdoctoral fellow (Metagenome/Metabolome/Human digestive tract #microbiome).
The position is available immediately and involves working with existing datasets from our lab. #postdoc #postdoctoral
Location: USA - Omaha, Nebraska
Apply at: unmc.peopleadmin.com/postings/91621

Microbiome linkage to diet was used to interrogate cohorts (259,000 participants) to understand the relationship to colorectal cancer #microbiome #nutrition #diet #cohort #Microbiology #MicroSky @unmccom.bsky.social 🧪 🦠
doi.org/10.1053/j.ga...

Feeding intolerance after pediatric cardiac surgery is associated with dysbiosis, barrier dysfunction, and reduced short-chain fatty acids | American Journal of Physiology-Gastrointestinal and Liver Physiology Congenital heart disease (CHD) is the most common birth defect, occurring in roughly 40,000 U.S. births annually. Malnutrition and feeding intolerance (FI) in CHD range from 30% to 42% and are associated with longer hospitalization and increased mortality. Cardiopulmonary bypass (CPB) required for surgical repair of CHD induces a systemic inflammatory response worsening intestinal dysbiosis and leading to intestinal epithelial barrier dysfunction (EBD), possibly contributing to postoperative FI. The objective of this study was to determine the relationship of postoperative FI with intestinal microbiome, short-chain fatty acids (SCFAs), and EBD in pediatric CHD after cardiac surgery. This was a prospective study of patients aged 0–15 years undergoing cardiac surgery with CPB. Samples were collected preoperatively and postoperatively to evaluate the gut microbiome, plasma EBD markers, short-chain fatty acids (SCFAs), and plasma cytokines. Clinical data were collected to calculate a FI score and evaluate patient status postoperatively. We enrolled 26 CPB patients and identified FI (n = 13). Patients with FI had unique microbial shifts with the reduced SCFA-producing organisms Rothia, Clostridium innocuum, and Intestinimonas. Patients who developed FI had associated elevations in the plasma EBD markers claudin-2 (P < 0.05), claudin-3 (P < 0.01), and fatty acid binding protein (P < 0.01). Patients with FI had reduced plasma and stool SCFAs. Mediation analysis showed the microbiome functional shift was associated with reductions in stool butyric and propionic acid in patients with FI. In conclusion, we provide novel evidence that intestinal dysbiosis, markers of EBD, and SCFA depletion are associated with FI. These data will help identify mechanisms and therapeutics to improve clinical outcomes following pediatric cardiac surgery. NEW & NOTEWORTHY Feeding intolerance contributes to postoperative morbidity following pediatric cardiac surgery. The intestinal microbiome and milieu play a vital role in gut function. Short-chain fatty acids are gut and cardioprotective metabolites produced by commensal bacteria and help maintain appropriate barrier function. Depletion of these metabolites and barrier dysfunction contribute to postoperative feeding intolerance following cardiac surgery. Identifying mechanistic targets to improve the intestinal milieu with the goal of improved nutrition and clinical outcomes is critical.

The microbiome and associated postbiotics are involved in feeding intolerance after pediatric cardiac surgery #nutrition #microbiome #Microbiology #MicroSky 🧪 🦠 @unmc-chvr.bsky.social @unmccom.bsky.social
doi.org/10.1152/ajpg...

Hello, microbiome and metabolome. Thanks for your work

Figure 1. miRNAs regulate the intestinal epithelium homeostasis by altering lEC survival, proliferation, migration, and cell-to-cell interaction. In this model, the levels of mucosal miRNAs are increased in the intestine after exposure to various pathological stresses. Increased miRNAs inhibit expression of their target genes by decreasing stability and translation of the mRNAs, thus leading to disruption of the gut epithelium homeostasis. RNA binding proteins (RBPs) such as HuR and CUGBP1 can interact with miNAs including miR-195 and miR-222 and modulate their regulatory functions antagonistically or synergistically.

Overview the Intestinal mucosal adaptation in response to surgical stress & MicroRNAs in gut mucosal growth and adaptation

www.tandfonline.com/doi/full/10....

Tomographic reconstruction of treponemal cytoplasmic filaments reveals novel bridging and anchoring components An understanding of the involvement of bacterial cytoplasmic filaments in cell division requires the elucidation of the structural organization of those filamentous structures. Treponemal cytoplasmic...

Glad that it is easier to do reconstruction of tomograms for ultrastructure of #spirochetes. Congrats. doi.org/10.1046/j.1365-2958.2003.03864.x

I am so glad that electron tomography processing has improved since the day of the first spirochete tomogram. doi.org/10.1016/j.js...

Good day,
Would it be possible to be added to the list. Specialties microbiome/metabolome/microbiology. Thanks for doing this
www.researchgate.net/profile/Jacq...

My lab is looking for a postdoctoral fellow (metagenomics/Metabolomics/human digestive tract #microbiome).
The position is available immediately and involves working with existing datasets from our lab. #metabolome
Location: USA - Omaha, Nebraska
Apply at: unmc.peopleadmin.com/postings/88467

My lab is looking for a postdoctoral fellow (metagenomics/Metabolomics/human digestive tract microbiome).
The position is available immediately and involves working with existing datasets from our lab.
Location: USA - Omaha, Nebraska
Apply at: unmc.peopleadmin.com/postings/88467

Hello. Please add me to the list. Thanks in advance

Hello. Could you include me too. Thanks in advance

Hello. Please include me in the list. Thanks in advance

Hello, I would like to be included in the Microbiome pack as I have a track record in the field. Thanks in advance