The Interactive Fly

A complex relationship between the architecture of the basement membrane, its mechanical properties, and its ability to shape the Drosophila egg Basement membranes (BMs) are planar extracellular matrices that line the basal surfaces of epithelia and are essential components of most organs. Duri…

Anderson, M. T., Horne-Badovinac, S. (2025). A complex relationship between the architecture of the basement membrane, its mechanical properties, and its ability to shape the #Drosophila egg. Matrix Biol, www.sciencedirect.com/science/arti...

Plexin/Semaphorin antagonism orchestrates collective cell migration and organ sculpting by regulating epithelial-mesenchymal balance An axon guidance factor restricts gap growth in a non-neuronal migrating cell sheet, allowing organ sculpting.

Bischoff, M. C., Norton, J. E., Clark, S. E., Peifer, M. (2025). Plexin/Semaphorin antagonism orchestrates collective cell migration and organ sculpting by regulating epithelial-mesenchymal balance. Sci Adv, 11(25):eadu3741 www.science.org/doi/10.1126/...

Andreatta, G., Montagnese, S., Costa, R. (2025). Cold-Sensing TRP Channels and Temperature Preference Modulate Ovarian Development in the Model Organism #Drosophila melanogaster. Int J Mol Sci, 26(12) www.mdpi.com/1422-0067/26...

A stem cell activation state coupling spermatogenesis with social interactions in Drosophila males How social context affects gamete production is well understood in females across phyla but is largely undescribed in males. Here, Martin-Diaz and Herrera show that, in male flies, the presence of fem...

Martin-Diaz, J., Herrera, S. C. (2024). A stem cell activation state coupling spermatogenesis with social interactions in Drosophila males. Cell Rep, 43(8):114647 www.cell.com/cell-reports...

Single-cell transcriptome sequencing reveals that Wolbachia induces gene expression changes in Drosophila ovary cells to favor its own maternal transmission | mBio Wolbachia, an obligate endosymbiont in arthropods, can manipulate the reproduction system of the host to enhance its maternal transmission and reside in the host’s eggs for generations. Herein, we per...

Miao, Y. H., Dou, W. H., Liu, J., Huang, D. W., Xiao, J. H. (2024). Single-cell transcriptome sequencing reveals that Wolbachia induces gene expression changes in #Drosophila ovary cells to favor its own maternal transmission. mBio:e0147324 journals.asm.org/doi/10.1128/...

Lockyer, J. L., Reading, A., Vicenzi, S., ...., Foa, L., Lin, J. Y. (2024). Selective optogenetic inhibition of Gα(q) or Gα(i) signaling by minimal RGS domains disrupts circuit functionality and circuit formation. Proc Natl Acad Sci 121(36):e2411846121 www.pnas.org/doi/10.1073/...

Notch signaling promotes differentiation, cell death and autophagy in Drosophila hematopoietic system Notch signaling is a highly conserved pathway between mammals and Drosophila and plays a key role in various biological processes. Drosophila has emer…

Luo, F., Zhang, C., Shi, Z., Mao, T., Jin, L. H. (2024). Notch signaling promotes differentiation, cell death and autophagy in Drosophila hematopoietic system.Insect biochemistry and molecular biology, 173:104176 www.sciencedirect.com/science/arti...

ERK synchronizes embryonic cleavages in Drosophila Yang et al. report that, in addition to its well-known role in the transcriptional patterning of the Drosophila embryo, the first wave of ERK signaling also synchronizes embryonic cleavage divisions.

Akai, N., Yagi, Y., Igaki, T., Ohsawa, S. (2025). JNK signaling coordinates epithelial cell turnover through exocytosis in Drosophila ribosomal protein mutants. iScience, 28(6):112587 www.cell.com/developmenta...

Group Leader - Genome Biology Unit Are you ready to lead groundbreaking research in Genome Biology? Join us at EMBL! We are seeking a motivated scientist to lead an independent research group addressing exciting and original biological...

To all post-docs: The Genome Biology dept ‪@embl.org
has an Independent faculty position. Fantastic place to set up your lab –great package: core funding, fantastic Ph.D. students, cutting edge core facilities & great colleagues. Closing date Sept 19th
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...

Voltage-gated calcium channels act upstream of adenylyl cyclase Ac78C to promote timely initiation of dendrite regeneration Author summary To last a lifetime, neurons must have robust stress and injury response pathways. While axon regeneration has long been appreciated as an important neuronal repair pathway, dendrite reg...

Hertzler, J. i., Teng, J., ...., Mahata, G., Kumar, N., Rolls, M. M. (2024). Voltage-gated calcium channels act upstream of adenylyl cyclase Ac78C to promote timely initiation of dendrite regeneration. PLoS Genet, 20(8):e1011388 journals.plos.org/plosgenetics...

Choi, B. J., Chen, Y. C., Desplan, C. (2025). Retinal Calcium Waves Coordinate Uniform Tissue Patterning of the Drosophila Eye. bioRxiv www.biorxiv.org/content/10.1...

ERK synchronizes embryonic cleavages in Drosophila Yang et al. report that, in addition to its well-known role in the transcriptional patterning of the Drosophila embryo, the first wave of ERK signaling also synchronizes embryonic cleavage divisions.

Yang, L., Zhu, A., Aman, J. M., Denberg, D., Kilwein, M. D., Marmion, R. A., Johnson, A. N. T., Veraksa, A., Singh, M., Wuhr, M., Shvartsman, S. Y. (2024). ERK synchronizes embryonic cleavages in Drosophila. Dev Cell, www.cell.com/developmenta...

ERK synchronizes embryonic cleavages in Drosophila Yang et al. report that, in addition to its well-known role in the transcriptional patterning of the Drosophila embryo, the first wave of ERK signaling also synchronizes embryonic cleavage divisions.

Yang, L., Zhu, A., Aman, J. M., Denberg, D., Kilwein, M. D., Marmion, R. A., Johnson, A. N. T., Veraksa, A., Singh, M., Wuhr, M., Shvartsman, S. Y. (2024). ERK synchronizes embryonic cleavages in #Drosophila. Dev Cell www.cell.com/developmenta...

Favaro, M., Mauri, S., Bernardo, G., Zordan, M. A., Mazzotta, G. M., Ziviani, E. (2024). Usp14 down-regulation corrects sleep and circadian dysfunction of a #Drosophila model of Parkinson's disease. Frontiers in neuroscience, 18:1410139 www.frontiersin.org/journals/neu...

Suarez, G. O., Kumar, D. S., Brunner, H., ..., Stahl, A., Bidaye, S. S., Tomchik, S. M. (2024). Neurofibromin deficiency alters the patterning and prioritization of motor behaviors in a state-dependent manner. bioRxiv, www.biorxiv.org/content/10.1...

Sex- and strain-dependent effects of ageing on sleep and activity patterns in Drosophila The fruit fly Drosophila is a major discovery platform in the biology of ageing due to its balance of relatively short lifespan and relatively complex physiology and behaviour. Previous studies have s...

Woodling, N. (2024). Sex- and strain-dependent effects of ageing on sleep and activity patterns in #Drosophila. PLoS One, 19(8):e0308652 journals.plos.org/plosone/arti...

Regulation of proteostasis by sleep through autophagy in Drosophila models of Alzheimer’s disease Sleep and circadian rhythm dysfunctions are common clinical features of Alzheimer’s disease (AD). Increasing evidence suggests that in addition to being a symptom, sleep disturbances can also drive th...

Ortiz-Vega, N., Lobato, A. G., Canic, T., Zhu, Y., Lazopulo, S., Syed, S., Zhai, R. G. (2024). TRegulation of proteostasis by sleep through autophagy in Drosophila models of Alzheimer's disease. Life science alliance www.life-science-alliance.org/content/7/11...

Ibrahim, R., Bahilo Martinez, M., Dobson, A. J. (2024). Rapamycin's lifespan effect is modulated by mito-nuclear epistasis in Drosophila. Aging Cell. 23(12):e14328. pubmed.ncbi.nlm.nih.gov39225061

Two novel DnaJ chaperone proteins CG5001 and P58IPK regulate the pathogenicity of Huntington’s disease related aggregates - Scientific Reports Scientific Reports - Two novel DnaJ chaperone proteins CG5001 and P58IPK regulate the pathogenicity of Huntington’s disease related aggregates

Deo, A., Ghosh, R., Ahire, S., Marathe, S., Majumdar, A., Bose, T. (2024). Two novel DnaJ chaperone proteins CG5001 and P58iPK regulate the pathogenicity of Huntington's disease related aggregates. Sci Rep, 14(1):20867 www.nature.com/articles/s41...

Two novel DnaJ chaperone proteins CG5001 and P58IPK regulate the pathogenicity of Huntington’s disease related aggregates - Scientific Reports Scientific Reports - Two novel DnaJ chaperone proteins CG5001 and P58IPK regulate the pathogenicity of Huntington’s disease related aggregates

Deo, A., Ghosh, R., Ahire, S., Marathe, S., Majumdar, A., Bose, T. (2024). Two novel DnaJ chaperone proteins CG5001 and P58iPK regulate the pathogenicity of Huntington's disease related aggregates. Sci Rep, 14(1):20867 www.nature.com/articles/s41...

Protein-coding circular RNA enhances antiviral immunity via JAK/STAT pathway in Drosophila | mBio Eukaryotic hosts possess a complex, multilayered immune system that guards against pathogen invasion. In fruit flies, RNA interference (RNAi) drives robust antiviral immunity, prompting many viruses t...

Guo, D., Xu, W., Cui, T., Rong, Q., Wu, Q. (2024). Protein-coding circular RNA enhances antiviral immunity via JAK/STAT pathway in #Drosophila. mBio:e0146924 journals.asm.org/doi/10.1128/...

Prevalent Fast Evolution of Genes Involved in Heterochromatin Functions Abstract. Heterochromatin is a gene-poor and repeat-rich genomic compartment universally found in eukaryotes. Despite its low transcriptional activity, het

Lin, L., Huang, Y., McIntyre, J., Chang, C. H., Colmenares, S., Lee, Y. C. G. (2024). Prevalent fast evolution of genes involved in heterochromatin functions. Mol Biol Evol academic.oup.com/mbe/article/...

Berardi, S., Rhodes, J. A., Berner, M. C., ..., Petrov, D. A., Rajpurohit, S., Schmidt, P. (2024). Drosophila melanogaster pigmentation demonstrates adaptive phenotypic parallelism but genomic unpredictability over multiple timescales. bioRxiv www.biorxiv.org/content/10.1...

Selection for stress tolerance and longevity in Drosophila melanogaster have strong impacts on microbiome profiles - Scientific Reports Scientific Reports - Selection for stress tolerance and longevity in Drosophila melanogaster have strong impacts on microbiome profiles

Kristensen, T. N., Schonherz, A. A., Rohde, P. D., Sorensen, J. G., Loeschcke, V. (2024). Selection for stress tolerance and longevity in #Drosophila melanogaster have strong impacts on microbiome profiles. Sci Rep, 14(1):17789 www.nature.com/articles/s41...

TF-High-Evolutionary: In Vivo Mutagenesis of Gene Regulatory Networks for the Study of the Genetics and Evolution of the Drosophila Regulatory Genome Abstract. Understanding the evolutionary potential of mutations in gene regulatory networks is essential to furthering the study of evolution and developme

Li, X. C., Srinivasan, V., Laiker, I., Misunou, N., Frankel, N., Pallares, L. F., Crocker, J. (2024). TTF-High-Evolutionary: In Vivo Mutagenesis of Gene Regulatory Networks. Mol Biol Evol, 41(8) academic.oup.com/mbe/article/...

Transformation of meiotic drive into hybrid sterility in Drosophila Genomic conflicts involving meiotic drivers are thought to explain the rapid evolution of hybrid male sterility between recently diverged populations. Ther

Bladen, J., Nam, H. J., Phadnis, N. (2024). Transformation of meiotic drive into hybrid sterility in #Drosophila. Genetics, academic.oup.com/genetics/art...

Alzheimer’s genetic risk factor Bin1 controls synapse vesicle exo-endocytosis in inhibitory synapses Barata et al. show that the Alzheimer’s risk gene BIN1 is critical for the stability of inhibitory synapses. BIN1 deficiency accelerates the synaptic vesicle endocytic cycle, leading to synapse loss a...

🧠 What if Alzheimer’s risk starts at the synapse?

In our new study led by Mariana Barata, we show that BIN1, a key AD risk gene, regulates inhibitory synapses—loss of BIN1 → hyperexcitability before Aβ.

www.cell.com/cell-reports...

“The connectome shows that LT52 is anatomically positioned to inhibit the neural networks involved in steering toward a visual object in the environment. Thus, we suggest that LT52 functions to prevent the fly from steering toward its own leg.”

nice 😁

Mechanoresponsive regulation of myogenesis by the force-sensing transcriptional regulator Tono Zhang, Avellaneda, et al. identify the BTB-zinc-finger protein Tono as a mechanosensitive transcriptional regulator during flight muscle development in Drosophila. After sarcomere assembly, high compr...

Zhang, X., Avellaneda, J., Spletter, M. L., Lemke, S. B., Mangeol, P., Habermann, B. H., Schnorrer, F. (2024). Mechanoresponsive regulation of myogenesis by the force-sensing transcriptional regulator Tono. Curr Biol www.cell.com/current-biol...

Kos, P., Baumann, O. (2024). Spatial arrangement, polarity, and posttranslational modifications of the microtubule system in the #Drosophila eye. Cell and tissue research pubmed.ncbi.nlm.nih.gov/39152365/