The Interactive Fly

Ranxhi, B., Bangash, Z., Chbihi, Z. M., Qadri, Z., Islam, N. N., Todi, S. V., LeWitt, P. A., Tsou, W. L. (2025). Regulation of polyamine interconversion enzymes affects α-Synuclein levels and toxicity in a Drosophila model of Parkinson's Disease. Res Sq, pubmed.ncbi.nlm.nih.gov/40470180/

Pasam, E. S., Madamanchi, K., Melkani, G. C. (2025). Dissecting Metabolic Control of Behaviors and Physiology During Aging in Drosophila. Res Sq, www.researchsquare.com/article/rs-6...

Salvianolic acid B ameliorates Aβ42 toxicity in Aβ42-expressing Drosophila model: behavioral and transcriptomic profiling - Metabolic Brain Disease Alzheimer’s disease (AD) is one of the most common neurodegenerative diseases worldwide. It is characterized by the accumulation of amyloid-beta (Aβ) plaques in which Aβ42 is the most toxic and aggres...

Tan, F. H. P., Azzam, G., Najimudin, N., Shamsuddin, S., Zainuddin, A., Kasihmuddin, M. S. M. (2025). Salvianolic acid B ameliorates Aβ42 toxicity in Aβ42-expressing Drosophila model: behavioral and transcriptomic profiling. Metab Brain Dis, 40(5):204 link.springer.com/article/10.1...

DNA damage response defects induced by the formation of TDP-43 and mutant FUS cytoplasmic inclusions and their pharmacological rescue - Cell Death & Differentiation Cell Death & Differentiation - DNA damage response defects induced by the formation of TDP-43 and mutant FUS cytoplasmic inclusions and their pharmacological rescue

Modafferi, S., Farina, S., Esposito, F., Brandi, O., ...., d'Adda di Fagagna, F., Gioia, U., Francia, S. (2025). DNA damage response defects induced by the formation of TDP-43 and mutant FUS cytoplasmic inclusions and their pharmacological rescue. Cell Death Differ, www.nature.com/articles/s41...

Frontiers | A phylogenetic analysis of the CDKL protein family unravels its evolutionary history and supports the Drosophila model of CDKL5 deficiency disorder The human CDK-like (CDKL) family of serine‒threonine kinases has five members (CDKL1-5), with a conserved N-terminal kinase domain and variable C-termini. Am...

Martin-Carrascosa, M. D. C., Palacios-Martinez, C., Galindo, M. I. (2025). A phylogenetic analysis of the CDKL protein family unravels its evolutionary history and supports the Drosophila model of CDKL5 deficiency disorder. Front Cell Dev Biol, 13:1582684 www.frontiersin.org/journals/cel...

Distinct systemic impacts of Aβ42 and Tau revealed by whole-organism snRNA-seq Park and Lu et al. create a whole-organism Alzheimer’s disease (AD) Fly Cell Atlas to reveal how AD-associated proteins systemically affect the brain and body. Their work uncovers distinct effects of ...

Park, Y. J., Lu, T. C., Jackson, T., Goodman, L. D., ...., Zheng, H., Qi, Y., Bellen, H. J., Li, H. (2025). Distinct systemic impacts of Aβ42 and Tau revealed by whole-organism snRNA-seq. Neuron, 113(13):2065-2082 www.cell.com/neuron/abstr...

Moon, M., Yun, J., Pyeon, M., Yun, J., Yang, J., Yeom, H. D., Lee, G., Choi, Y., Lee, J., Lee, J. H. (2025). Phenethyl Acetate as an Agonist of Insect Odorant Receptor Co-Receptor (Orco): Molecular Mechanisms and Functional Insights. Int J Mol Sci, 26(11) www.mdpi.com/1422-0067/26...

FEBS Press A series of modified FAD cofactors have been used to modulate the photochemistry of FAD-containing cryptochrome. When 7-halogenated FADs were used, a significantly faster signaling-state formation wa...

Okasha, M., Chen, J., Ayekoi, A., Jacob, E., Radtke, V., Schmidt, A., Bacher, A., Weber, S., Schleicher, E. (2025). Linear free energy relationship between reduction potential and photoreduction rate: studies on Drosophila cryptochrome. Febs j, febs.onlinelibrary.wiley.com/doi/10.1111/...

Kim, K. Y., Hwang, Y. L., Yeom, S., Kwon, S. H., Jeon, S. H. (2025). Pss knockdown in the midgut causes growth retardation in Drosophila similar to that in human LMHD. Dev Dyn, anatomypubs.onlinelibrary.wiley.com/doi/10.1002/...

Hsc70-4: An unanticipated mediator of dsRNA internalization in Drosophila Hsc70-4 localizes to the cell surface of Drosophila cells, binds to exogenous dsRNA, and mediates its internalization.

Fletcher, S. J., Bardossy, E., Tome-Poderti, L., Moss, T., Mongelli, V., Frangeul, L., Blanc, H., Verdier, Y., Vinh, J., Mukherjee, S., Saleh, M. C. (2025). Hsc70-4: An unanticipated mediator of dsRNA internalization in Drosophila. Sci Adv, 11(20):eadv1286 www.science.org/doi/10.1126/...

Krishnan, H., Muzaffar, S., Sharma, S., Ramya, V., Ghosh, A., Sowdhamini, R., Padinjat, R. (2025). Conserved biochemical activity and function of phosphatidylinositol 5 phosphate 4 kinase regulates growth & development. Cell Sci, journals.biologists.com/jcs/article-...

Vostok: A looping factor for the organization of the regulatory genome in the Drosophila brain In Drosophila, tethering elements are DNA regulatory regions that facilitate long-range interactions between enhancers and promoters as well as between the promoters of distant paralogous genes. Hu et...

Hu, J., Li, X., Lomaev, D., Vorobyeva, N. E., Levine, M., Erokhin, M., Chetverina, D. (2025). Vostok: A looping factor for the organization of the regulatory genome in the Drosophila brain. Mol Cell, 85(12):2442-2451 www.cell.com/molecular-ce...

Huang, R. N., Luo, S. Y., Huang, T., ...., Li, L. Y., Tang, B., Qiao, J. D. (2025). The interaction of UBR4, LRP1, and OPHN1 in refractory epilepsy: Drosophila model to investigate the oligogenic effect on epilepsy. Neurobiol Dis, 212:106955 www.sciencedirect.com/science/arti...

Neurotensin inhibits AMPK activity and concurrently enhances FABP1 expression in small intestinal epithelial cells associated with obesity and aging - Experimental & Molecular Medicine Neurotensin (NTS) is a hormone primarily localized to the gut and brain that affects various bodily functions. Researchers have found that high levels of a form of NTS, called pro-NTS, are linked to d...

Li, J., Song, J., Yan, B., Wu, H., ...., Jia, J., Weiss, H. L., Evers, B. M. (2025). Neurotensin inhibits AMPK activity and enhances FABP1 expression in small intestinal epithelial cells associated with obesity and aging. Exp Mol Med, 57(6):1189-1201 www.nature.com/articles/s12...

Marnas, P., Lupold, S., ..., Zarogiannis, S., Rouka, E. (2025). Modeling COPD in Drosophila by cigarette smoke: functional changes and alterations in the expression of COPD-relevant orthologous genes. Am J Physiol Regul Integr Comp Physiol, 329(1):R13-r19 journals.physiology.org/doi/full/10....

Long, J., Jones, S. G., Serna, A., ..., Verstreken, P., Huynen, M. A., Luhy, K., Coll-Tane, M., Schenck, A. (2025). A conserved epilepsy-associated gene co-expression module identifies increased metabolic rate as a shared pathomechanism. Dis Model Mech, journals.biologists.com/dmm/article/...

Inhibition of NAD-GPx4 axis and MEK triggers ferroptosis to suppress pancreatic ductal adenocarcinoma This study using Drosophila and mammalian models revealed that dual inhibition of GPx4 and MEK induces ferroptosis in pancreatic cancer by promoting iron accumulation and oxidative stress, highlightin...

Jiang, H., Satoh, Y., Yamamura, R., Ooshio, T., ...., Hirata, T., Osawa, T., Goda, K., Sonoshita, M. (2025). Inhibition of NAD-GPx4 axis and MEK triggers ferroptosis to suppress pancreatic ductal adenocarcinoma. Mol Ther, www.cell.com/molecular-th...

Age-associated decline of Coenzyme A leads to intestinal stem cells dysfunction via disturbing iron homeostasis Author summary In our study, we explored the connection between the aging of adult stem cells and the rise of age-related diseases, uncovering a significant metabolic link. As stem cells age, a key me...

Liu, Z., Du, G., Chen, Y., Chen, H. (2025). Age-associated decline of Coenzyme A leads to intestinal stem cells dysfunction via disturbing iron homeostasis. PLoS Genet, 21(6):e1011704 journals.plos.org/plosgenetics...

Microscopy preprints – bioimage analysis - FocalPlane Microscopy preprints – bioimage analysis - News

📢Check out our latest #preprint list on FocalPlane
This list focusses on the latest research on bioimage analysis and data management. Let us know if there are any preprints that we should add to our list and send us recommendation for the next one!
focalplane.biologists.com/2025/11/14/m...

Neuroendocrine control of intestinal regeneration through the vascular niche in Drosophila Adult intestinal plasticity and tissue repair involves complex and reciprocal multicellular interactions. Medina, Perochon, et al. report a signaling axis between hormone-producing cells in the intest...

Congrats @corderolab.bsky.social‬ !!

Neuroendocrine control of intestinal regeneration through the vascular niche in Drosophila: Developmental Cell www.cell.com/developmenta...

Lee, S. H., Hwang, D., ..., Yun, E. Y. (2025). The Identification of a Glucuronyltransferase-Related Gene, GlcAT-S, with Putative Mucus Protection and Anti-Inflammatory Effects from Gut-Damaged Drosophila by Dextran Sulfate Sodium (DSS). Biology (Basel), www.mdpi.com/2079-7737/14...

Hamilton, W., Massey, J., Hardy, E., Lopez-Madrigal, S., Phelps, M., Martin, M., Newton, I. (2025). Wolbachia uses ankyrin repeats to target specific fly proteins. bioRxiv, www.biorxiv.org/content/10.1...

Microbial Community Dynamics in Natural Drosophila melanogaster Populations Across Seasons The characterisation of fungal and bacterial communities associated with three field populations of Drosophila melanogaster in Germany revealed consistent but also population-specific changes across ...

Lemoine, M. M., Wohner, T., Kaltenpoth, M. (2025). Microbial Community Dynamics in Natural Drosophila melanogaster Populations Across Seasons. Environ Microbiol, 27(6):e70104 enviromicro-journals.onlinelibrary.wiley.com/doi/10.1111/...

Xgr is involved in body size control in Drosophila through promoting glucose uptake in the Malpighian tubules Body size control is fundamental to development and requires proper energy engagement. One of the key energy sensing factors is AMP-activated protein …

Lin, Z., He, Z., Guo, J., Ji, X., Hu, Z., Tang, Y., Wei, C., Liu, J., Wu, W., Ma, J., Jiao, R. (2025). Xgr is involved in body size control in Drosophila through promoting glucose uptake in the Malpighian tubules. J Genet Genomics www.sciencedirect.com/science/arti...

Circadian clock-independent ultradian rhythms in lipid metabolism in the Drosophila fat body The role of circadian clocks in regulating metabolic processes is well known; however, their impact on metabolic states across species and life stages remains largely unexplored. This study investigat...

Lago Solis, B., Koch, R., Nagoshi, E. (2025).. Circadian clock-independent ultradian rhythms in lipid metabolism in the Drosophila fat body. J Biol Chem, 301(6):110245 www.jbc.org/article/S002...

Adenosine signaling in glia modulates metabolic state-dependent behavior in Drosophila De Backer et al. dissect the roles of adenosine signaling in glia subtypes in the fly nervous system and their relationship to feeding-state-dependent behavior. Their results provide a potentially con...

De Backer, J. F., Karges, T., Papst, J., Pinar, Z. N., Coman, C., Ahrends, R., Xu, Y., Garcia-Ccceres, C., Grunwald Kadow, I. C. (2025). Adenosine signaling in glia modulates metabolic state-dependent behavior in Drosophila.Cell Rep, 44(6):115765 www.cell.com/cell-reports...

Amos, L., Wigby, S., Dougherty, L. R. (2025). Short-term increases in rival number improves single mating productivity in male Drosophila. Behav Ecol, 36(3):araf032 academic.oup.com/beheco/artic...

Exoskeletal cuticle proteins enable Drosophila locomotion Exo- and Endoskeleton function enables muscle-mediated locomotion in animals. In mammals, the defective protein matrix of bones found in systematic sk…

Gopfert, M., Yang, J., Rabadiya, D., Riedel, D., Moussian, B., Behr, M. (2025). Exoskeletal cuticle proteins enable Drosophila locomotion. Acta Biomater www.sciencedirect.com/science/arti...

Karashchuk, L., Li, J. S., Chou, G. M., Walling-Bell, S., Brunton, S. L., Tuthill, J. C., Brunton, B. W. (2025). Sensorimotor delays constrain robust locomotion in a 3D kinematic model of fly walking.Elife, 13 elifesciences.org/articles/99005

Subasi, B. S., Finsterbusch, A. L., Buge, M., Armitage, S. A. O. (2025). Two matings lead to more copulatory wounding than a single mating in female Drosophila melanogaster. Proc Biol Sci, 292(2049):20250523 royalsocietypublishing.org/doi/10.1098/...