Christoph Schell, MD,PhD

Inhibition of the inflammasome ameliorates orthologous polycystic kidney disease | PNAS Autosomal dominant polycystic kidney disease (ADPKD) is the most common genetic kidney disease. Limited treatment options lead to renal failure in ...

A new exciting and highly collaborative @sfb1453.bsky.social paper by NephGen groups Börries, Schell, and Kühn in @pnas.org

Inhibition of the inflammasome ameliorates orthologous polycystic kidney disease | PNAS www.pnas.org/doi/10.1073/...

Happy to share our latest work on the role of actin-mediated ciliogenesis in the context of glomerular kidney disease! Huge team effort!! Many thanks to everyone in involved!

Arp2/3-dependent regulation of ciliogenesis governs adaptive distal tubular epithelial cell states in kidney disease Proteinuria causes ciliary elongation and actin cytoskeleton remodeling, revealing a key mechanism in kidney disease progression.

www.science.org/doi/10.1126/...

Please spread the word and sign up for our exciting spring meeting in Nottingham with amazing speakers on the topic of ECM, immunity and infection. An exciting and developing field! paacr4.wixsite.com/bsmb-spring2...

Encompassing view of spatial and single-cell RNA sequencing renews the role of the microvasculature in human atherosclerosis - Nature Cardiovascular Research Bleckwehl et al. present a spatial transcriptomic map of atherosclerotic plaques across disease stages, revealing cellular recruitment and migration patterns and intercellular communication dynamics a...

Our new paper put today @natureCVR led by @sikandhayat.bsky.social Tore Bleckwehl in collab with NovoNordisk 👇👇 www.nature.com/articles/s44...

www.uniklinik-freiburg.de/karriere/ste...

We are hiring!!! The labs of Oliver Schilling, Melanie Föll and the Schell/Matripath Lab at University Medical Center Freiburg are seeking for PhD students in the field of matrix and cancer research. Projects are part of #SFBNephgen.

Our manuscript describing #MatriCom, a web application we developed in collaboration with @valerioizzi.bsky.social to infer #ECM communication systems from #scRNASeq datasets is now available on @biorxivpreprint.bsky.social!

Renal phenotyping in a hypomorphic murine model of propionic aciduria reveals common pathomechanisms in organic acidurias Scientific Reports - Renal phenotyping in a hypomorphic murine model of propionic aciduria reveals common pathomechanisms in organic acidurias

Check out our newest joint publication by @sfb1453.bsky.social PIs Anke Schumann, Christoph Schell @nephpath.bsky.social, Oliver Schilling and Michael Köttgen in #ScientificReports‍ 👩‍🔬👨‍🔬🔬🎉. #NephSky @uniklinik-fr.bsky.social @uni-freiburg.de rdcu.be/d3UXF

Method of the Year 2024: spatial proteomics - Nature Methods Approaches for profiling the spatial proteome in tissues are the basis of atlas-scale projects that are delivering on their promise for understanding biological complexity in health and disease.

I could not be more thrilled to announce the Nature Methods @naturemethods.bsky.social Method of the Year is Spatial Proteomics! Please see our editorial as a roadmap to the fantastic content in this special issue! www.nature.com/articles/s41...

Fun fact:

Although scientific journals have existed in some form since the 1600s, external peer review only became standard in the 1970s.

(So yeah… Einstein’s theories, Watson & Crick’s double helix, penicillin, insulin, etc. - all published without helpful comments from Reviewer 2.)

Imagine seeing a disease's impact on every cell in the body. Now, you can! We introduce MouseMapper, an AI tool to reveal system-wide disease perturbations. It reveals obesity-induced changes in facial nerves & body-wide inflammation 👉🧵https://biorxiv.org/content/10.1101/2024.08.18.608300v1.full.pdf

Renal Angptl4 is a key fibrogenic molecule in progressive diabetic kidney disease Angplt4 deficiency in podocytes and renal tubule cells is protective in diabetes.

In depth analysis on the role of Angptl4 in diabetic kidney disease and potential for therapeutic intervention..

www.science.org/doi/10.1126/...

KANK1 promotes breast cancer development by compromising Scribble-mediated Hippo activation - Nature Communications The role of the focal adhesion protein KANK1 in cancer progression is not yet clearly understood. Here the authors find that KANK1 competes with the polarity protein Scribble at cell-cell junctions fo...

www.nature.com/articles/s41...

In fact, fantastic spot. Stay tuned.. more to come 😉

Fantastic MTB ride in the mystic Black Forest!