@bernard-mari.bsky.social
Biologist @IPMC_Sophia, @CNRS, @UCA_Research, interested and often stuck in #non-codingRNA, #Genomics, #IPF, #LungHealth & #RegenerativeMedicine
7/7 Our data suggest that in a reversible fibrosis model, sCap are recruited and can act as progenitor cells to reconstitute the gCap pool to regenerate the integrity of the alveolar endothelial capillaries while aging appears to delay this process. 🙏 to our supports @agencerecherche.bsky.social
06.08.2025 16:20 — 👍 0 🔁 0 💬 0 📌 06/7 We also found that aging altered the transcriptome of gCap in control mice, with a signature suggestive of a pro-fibrotic and pro-inflammatory state, that may participate in the dysfunction of other cells in the alveolar niche and impede alveolar regeneration.
06.08.2025 16:20 — 👍 0 🔁 0 💬 1 📌 0
5/7 RNA velocity approach indicated that following lung injury, sCap are recruited and may function as progenitor cells that can initiate a differentiation process, transiting through Lrg1+ gCap before reaching the physiological gCap cell state.
06.08.2025 16:20 — 👍 0 🔁 0 💬 1 📌 0
4/7 These systemic EC corresponds to two distinct populations: one with venous macrovascular origin previously defined as SV EC and a second one lacking typical macrovascular and venous markers, corresponding to systemic capillary EC (sCap), in agreement with a recent study in COVID patients.
06.08.2025 16:20 — 👍 0 🔁 0 💬 1 📌 0
3/7 .. we identified aging-associated changes in PCEC pops, including aCap and gCap, shifting towards a pro-angiogenic phenotype expressing Lrg1 and associated with alveolar niche regeneration, as well as the emergence of homologous Col15a1-positive systemic EC previously identified in IPF
06.08.2025 16:20 — 👍 1 🔁 0 💬 1 📌 02/7 Using scRNA-seq and spatial transcriptomics, we present a whole picture of cell dynamic changes in young and aged lungs during fibrosis formation and resolution at 3 time points. Focusing on transcriptomic alterations correlated with a delayed fibrosis resolution in aged mice...
06.08.2025 16:20 — 👍 0 🔁 0 💬 1 📌 0
1/7 Our paper describing how aging affects reprogramming of PCEC after lung injury is out at Nat Commun: rdcu.be/ezyjv! Special 👏 to Marin Truchi and @mamchisola.bsky.social for this huge work with colleagues @univcotedazur.bsky.social @cnrsbiologie.bsky.social #IHURespirERA and all collaborators!
06.08.2025 16:20 — 👍 0 🔁 0 💬 1 📌 0
The #RespirERA IHU was out in force at the #2025LungGRC in Lucca with Manon Durandy, Laetitia Seguin (IRCAN) and @laure-em.bsky.social #IPMC Great science, wonderful exchanges with old colleagues and new connections and what a gorgeous place ! #LungResearch
01.08.2025 10:04 — 👍 2 🔁 2 💬 0 📌 0
Second webinaire 2025 dans le cadre des Activités scientifiques conjointes AIRS-RESPIRenT-BeRS organisé par les étudiants de 2ème et 3ème cycle sur la relation entre science et politique !
Programme et inscription:
👉 splf.fr/activites-sc...
@soc-pneumo-splf.bsky.social @respirent-splf.bsky.social
Premier webinaire 2025 dans le cadre des Activités scientifiques conjointes AIRS-RESPIRenT-BeRS sur le thème du cancer du poumon le vendredi 11 avril.
Programme et inscription gratuite :
👉 splf.fr/activites-sc...
#Recherche #respiratoire #pneumologie #infection
@soc-pneumo-splf.bsky.social
👏 again to Arun Lingampally @jlugiessen.bsky.social and Marin truchi @univcotedazur.bsky.social @cnrsbiologie.bsky.social and all collaborators and supports! @agencerecherche.bsky.social
13.02.2025 23:47 — 👍 0 🔁 0 💬 0 📌 0
The follow-up has just been released in Aging Cell dealing with the impact of aging on differentiation trajectories in the MYF to LIF switch: onlinelibrary.wiley.com/doi/10.1111/...
13.02.2025 23:47 — 👍 0 🔁 0 💬 1 📌 0With a nice editorial “Tracing the origins of fibrotic fibroblasts: does the name matter? Look at the genes!” publications.ersnet.org/content/erj/...
13.02.2025 23:47 — 👍 0 🔁 0 💬 1 📌 02 nice stories thanks to our collab with Saverio Bellusci @jlugiessen.bsky.social! The final version of our first paper out at Eur. Resp. J. bit.ly/3ZPVCtb focusing on the heterogeneity of activated MYFs and supporting the LIF to MYF reversible switch during fibrosis formation and resolution
13.02.2025 23:47 — 👍 0 🔁 0 💬 1 📌 0
Very nice presentation of Marine Gautier-Isola at the IdEx Young Researcher Award 2025 in Nice ! An inspiring day of science with talented young scientists, many thanks to the Côte d’Azur University for their support!
05.02.2025 22:56 — 👍 1 🔁 0 💬 0 📌 0Great work, congrats to all the team 👏
04.02.2025 23:38 — 👍 0 🔁 0 💬 1 📌 0Je viens de faire mon #eXit! L’exode de X est massif. Ne perdez pas un seul de vos abonnés. Grâce à #OpenPortability j’ai inscrit 593 nouveaux passagers pour partir vers #BlueSky & #Mastodon. Retrouvez automatiquement vos communautés le #20Janvier via openportability.org !
28.01.2025 17:51 — 👍 2 🔁 0 💬 0 📌 0
