Bernard Mari

Our latest paper just came out in Molecular Systems Biology !

Transition between cell states of sensitivity reveals molecular vulnerability of drug-tolerant cells @molsystbiol.org

www.embopress.org/doi/full/10....

7/7 Our data suggest that in a reversible fibrosis model, sCap are recruited and can act as progenitor cells to reconstitute the gCap pool to regenerate the integrity of the alveolar endothelial capillaries while aging appears to delay this process. 🙏 to our supports @agencerecherche.bsky.social

6/7 We also found that aging altered the transcriptome of gCap in control mice, with a signature suggestive of a pro-fibrotic and pro-inflammatory state, that may participate in the dysfunction of other cells in the alveolar niche and impede alveolar regeneration.

5/7 RNA velocity approach indicated that following lung injury, sCap are recruited and may function as progenitor cells that can initiate a differentiation process, transiting through Lrg1+ gCap before reaching the physiological gCap cell state.

4/7 These systemic EC corresponds to two distinct populations: one with venous macrovascular origin previously defined as SV EC and a second one lacking typical macrovascular and venous markers, corresponding to systemic capillary EC (sCap), in agreement with a recent study in COVID patients.

3/7 .. we identified aging-associated changes in PCEC pops, including aCap and gCap, shifting towards a pro-angiogenic phenotype expressing Lrg1 and associated with alveolar niche regeneration, as well as the emergence of homologous Col15a1-positive systemic EC previously identified in IPF

2/7 Using scRNA-seq and spatial transcriptomics, we present a whole picture of cell dynamic changes in young and aged lungs during fibrosis formation and resolution at 3 time points. Focusing on transcriptomic alterations correlated with a delayed fibrosis resolution in aged mice...

Aging affects reprogramming of pulmonary capillary endothelial cells after lung injury in male mice Nature Communications - Here the authors report single-cell and spatial transcriptomics of young and aged male fibrotic mouse lungs. Age-related alterations in capillary sub-populations are...

1/7 Our paper describing how aging affects reprogramming of PCEC after lung injury is out at Nat Commun: rdcu.be/ezyjv! Special 👏 to Marin Truchi and @mamchisola.bsky.social for this huge work with colleagues @univcotedazur.bsky.social @cnrsbiologie.bsky.social #IHURespirERA and all collaborators!

The #RespirERA IHU was out in force at the #2025LungGRC in Lucca with Manon Durandy, Laetitia Seguin (IRCAN) and @laure-em.bsky.social #IPMC Great science, wonderful exchanges with old colleagues and new connections and what a gorgeous place ! #LungResearch

Second webinaire 2025 dans le cadre des Activités scientifiques conjointes AIRS-RESPIRenT-BeRS organisé par les étudiants de 2ème et 3ème cycle sur la relation entre science et politique !
Programme et inscription:
👉 splf.fr/activites-sc...
@soc-pneumo-splf.bsky.social @respirent-splf.bsky.social

Premier webinaire 2025 dans le cadre des Activités scientifiques conjointes AIRS-RESPIRenT-BeRS sur le thème du cancer du poumon le vendredi 11 avril.
Programme et inscription gratuite :
👉 splf.fr/activites-sc...
#Recherche #respiratoire #pneumologie #infection
@soc-pneumo-splf.bsky.social

👏 again to Arun Lingampally @jlugiessen.bsky.social and Marin truchi @univcotedazur.bsky.social @cnrsbiologie.bsky.social and all collaborators and supports! @agencerecherche.bsky.social

Unraveling Alveolar Fibroblast and Activated Myofibroblast Heterogeneity and Differentiation Trajectories During Lung Fibrosis Development and Resolution in Young and Old Mice Model of LIF-to-aMYF reversible switch during fibrosis formation and resolution in old mice. The main contributors during fibrosis formation to Cthrc1+ aMYF are Acta2+ LIFhigh alveolar fibroblasts. D....

The follow-up has just been released in Aging Cell dealing with the impact of aging on differentiation trajectories in the MYF to LIF switch: onlinelibrary.wiley.com/doi/10.1111/...

With a nice editorial “Tracing the origins of fibrotic fibroblasts: does the name matter? Look at the genes!” publications.ersnet.org/content/erj/...

2 nice stories thanks to our collab with Saverio Bellusci @jlugiessen.bsky.social! The final version of our first paper out at Eur. Resp. J. bit.ly/3ZPVCtb focusing on the heterogeneity of activated MYFs and supporting the LIF to MYF reversible switch during fibrosis formation and resolution

Very nice presentation of Marine Gautier-Isola at the IdEx Young Researcher Award 2025 in Nice ! An inspiring day of science with talented young scientists, many thanks to the Côte d’Azur University for their support!

Great work, congrats to all the team 👏

Je viens de faire mon #eXit! L’exode de X est massif. Ne perdez pas un seul de vos abonnés. Grâce à #OpenPortability j’ai inscrit 593 nouveaux passagers pour partir vers #BlueSky & #Mastodon. Retrouvez automatiquement vos communautés le #20Janvier via openportability.org !