Björn Schumacher

Apply now for a fully funded #PhD position at the Cologne Graduate School of Ageing Research and become part of our vibrant #AgingResearch commmuny.
🗓️ Deadline: November 3, 2025.
ℹ️ More info: www.ageing-grad-school.de
📣 Spread the news!

What Jane Goodall Taught Us About Living a Long Life

What Jane Goodall Taught Us About Living a Long Life
The scientist, who died at 91 on Wednesday, was a model for healthy aging.
www.nytimes.com/2025/10/02/w...

mproving the stability of the genome thus reducing mutation accumulation and enhancing the maintenance of functional genomes. Great collaboration with Arturo Bujarrabal,
@garinis.bsky.social, , Jan Vijg @cecad.bsky.social @uniklinikkoeln.bsky.social @unicologne.bsky.social

Targeting DNA damage in ageing: towards supercharging DNA repair - Nature Reviews Drug Discovery DNA damage to the somatic genome has been identified as a major cause of ageing. This Perspective provides an overview of current understanding of the role of genome instability in the ageing process and assesses therapeutic strategies targeting the cellular response to DNA damage to delay ageing and prevent associated diseases.

Now out in print: Targeting DNA damage in ageing: towards supercharging DNA repair. New perspectives how we could tackle cancer and aging at their mechanistic root cause: I
www.nature.com/articles/s41...

Amazing retreat of the @dfg.de Research Unit FOR5504 on the Physiological Causes and Consequences of Genome Instability and the Institute for Genome Stability in Aging and Disease with keynotes by @apoetsch.bsky.social and @garinis.bsky.social

It was great fun speaking with Debbie Toiber and @barakrotblat.bsky.social on my path to science and why studying aging is so important to me. open.spotify.com/episode/2brg...

This review of our @crc1678.bsky.social member @bjornschumacher.bsky.social and @meyerdh.bsky.social is greatly summarizing fundamentals of the molecular biology of aging. What causes aging? Read the answer!

Aging by the clock and yet without a program [perspective by David Meyer, Alexei Maklakov & Björn Schumacher] www.nature.com/articles/s43...

The DREAM complex functions as conserved master regulator of somatic DNA-repair capacities - Nature Structural & Molecular Biology In this work, the authors show that the DREAM complex suppresses the expression of numerous DNA-repair proteins in somatic cells. Suppression of the DREAM complex, either by altering individual compon...

The first master regulator of DNA repair capacities that could be therapeutically targeted is the DREAM complex as we show here: www.nature.com/articles/s41...

The central role of DNA damage in the ageing process - Nature This Review examines the evidence showing that DNA damage is associated with ageing phenotypes, suggesting that it may have a central role as the cause of ageing.

For more on the central role of DNA damage in the aging process read here our review article in Nature @natureportfolio.nature.com www.nature.com/articles/s41...

Targeting DNA damage in ageing: towards supercharging DNA repair - Nature Reviews Drug Discovery DNA damage to the somatic genome has been identified as a major cause of ageing. This Perspective provides an overview of current understanding of the role of genome instability in the ageing process ...

For more on how the onslaught of DNA damage that drives the aging process could be therapeutically mitigated read our article on boosting DNA repair capacities here: www.nature.com/articles/s41...

Aging clocks based on accumulating stochastic variation - Nature Aging Meyer and Schumacher use simulations to show that accumulation of stochastic variation is sufficient to build clocks that can measure both chronological and biological age, sensitive to changes induce...

For more on how molecular noise can measure biological age read our stochastic clock paper here: www.nature.com/articles/s43...

Aging by the clock and yet without a program - Nature Aging Meyer and colleagues refute the idea that, as aging can be tracked precisely by clocks, it must be driven by a biological program. They propose that imperfect maintenance and repair processes resultin...

🔥🔥🔥Out now: our Perspectives article in @nataging.nature.com outlining how aging is driven by molecular damage leading to increasing molecular noise whose quantification could track aging with the precision of a clock @meyerdh.bsky.social @alexeimaklakov.bsky.social
www.nature.com/articles/s43...

👵🏻⏰👴🏻 Is aging a programmed process? Check out this perspective article in Nature Aging by our two #CRC1678 members @meyerdh.bsky.social and @bjornschumacher.bsky.social. Congratulations! 🥳

Aging by the clock and yet without a program - Nature Aging Meyer and colleagues refute the idea that, as aging can be tracked precisely by clocks, it must be driven by a biological program. They propose that imperfect maintenance and repair processes resultin...

🕰️ Is aging driven by a programmed/programmatic mechanism, or by the unavoidable burden of imperfect maintenance? Our perspective argues that aging reflects finite maintenance and reduced evolutionary pressure🧵🧪 www.nature.com/articles/s43... @bjornschumacher.bsky.social @alexeimaklakov.bsky.social

Registration open now! Join us for the most exciting Gordon Research Conferences on Systems Aging in 2026. Super exciting program with outstanding speakers from across the entire field. Ample opportunity to discuss your science with leaders in the Systems Aging Feld. www.grc.org/systems-agin...

🔥🔥🔥 Read now our latest article: The Somatic Impact on Inheritance and the Germline Control of the Soma | Annual Reviews - www.annualreviews.org/content/jour...

mtor and DNA damage in kidney health 👇

Thanks Or

Thanks Christian

Thanks Barak!

🔥🔥🔥Check out our latest paper on the kidney, wonderful collaboration with Fabian Braun & Christine Kurschat @cecad.bsky.social. Read now: JCI Insight - Loss of genome maintenance is linked to mTOR complex 1 signaling and accelerates podocyte damage insight.jci.org/articles/vie...

Register now for the 7th German-French DNA Repair Meeting, which will take place at the Campus Pierre et Marie Curie of Sorbonne University in Paris, France, from 5–7 November 2025. premc.org/dnarepair202...

Gesunde Lebenszeit verlängern Viele Menschen wissen durchaus, was ein gesunder Lebensstil wäre. Umsetzbar sind diese Ansprüche trotzdem nicht für jeden. Ein Paradigmenwechsel in der Medizin könnte helfen.

Paradigmenwechsel in der Medizin, um gesunde Lebenszeit verlängern www.nd-aktuell.de/artikel/1191...

Gesundes Altern ermöglichen: Leopoldina-Diskussionspapier empfiehlt Umdenken in Forschung und Medizin nachrichten.idw-online.de/pressrelease...

Enabling healthy ageing: @leopoldina.org discussion paper recommends shift in focus in research and medicine. We are proposing a Health-Extending Medicine in an Aging Society and define Prospects for Medical Research and Practice
www.leopoldina.org/en/press-1/p...

Gesundes Altern ermöglichen: Leopoldina-Diskussionspapier empfiehlt Umdenken in Forschung und Medizin. Hier sind die Ergebnisse unserer Diskussionen bei der @leopoldina.org für eine neue Medizin in einer alternden Gesellschaft. Lebenslange Gesundheit und Prävention ist erreichbar.

Targeting DNA damage in ageing: towards supercharging DNA repair - Nature Reviews Drug Discovery DNA damage to the somatic genome has been identified as a major cause of ageing. This Perspective provides an overview of current understanding of the role of genome instability in the ageing process ...

Targeting DNA damage in ageing: towards supercharging DNA repair www.nature.com/articles/s41...
rdcu.be/eqQ7R

This new Perspective discusses approaches to pharmacologically mitigate the adverse effects of DNA damage to prevent mutation-driven cancers and mitigate age-related degenerative diseases

Thanks Christian

Targeting DNA damage in ageing: towards supercharging DNA repair - Nature Reviews Drug Discovery DNA damage to the somatic genome has been identified as a major cause of ageing. This Perspective provides an overview of current understanding of the role of genome instability in the ageing process ...

www.nature.com/articles/s41...

massive review from @bjornschumacher.bsky.social & team! congratulations all.