Dr June M McKoy

Happy Halloween MedX and all those who follow and support our work. It’s nice to decompress this evening with my wonderful clinical team @drjunejd.bsky.social

Stunning Grand Rounds on “Exceptional Longevity: What’s it really like? Centenarians, their Kids, and How They Get There.”
Delivered @medicalcollegeofwi.bsky.social by renowned GeroScientist Dr Thomas Perls an international leader in the field of human exceptional longevity @drjunejd.bsky.social

‼️Our latest study, “Loss of STAT3 in acute myeloid leukemia favors tissue infiltration linked to CXCR4 signaling,” is now out in @bloodneoplasia.bsky.social

#AML #STAT3 #CXCR4 #MLL-AF9
www.sciencedirect.com/science/arti...

I’m having an amazing time at the National Academy of Medicine (NAM) annual mtg in Washington, D.C. today. AI is front and center as physician and nurse scientists discuss AI within the framework of healthcare in all its many facets @nationalacademies.org @drjunejd.bsky.social

This Radiation Mask…

My patient graduated from cancer this week.

This mask was his constant companion. Representing struggle and resilience.

Protection and escape.
This ritual transformation.

When words are insufficient …symbols supersede @drjunejd.bsky.social

Association of 2024–2025 Covid-19 Vaccine with Covid-19 Outcomes in U.S. Veterans | NEJM Amid the declining clinical severity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and diminishing public uptake of annual coronavirus disease 2019 (Covid-19) vaccines, ...

💉 2024–25 Covid-19 vaccine effectiveness

In U.S. veterans, the updated vaccine reduced 6-month risks of Covid-related ED visits (-29%), hospitalisations (-39%), and deaths (-64%) vs flu-only group.

🔗 doi.org/10.1056/NEJMoa2510226

#SciComm #COVID19 #Vaccines 🧪

READ OUR COMMENTARY ON PARP DIFFUSION THROUGHOUT THE USA @drjunejd.bsky.social

Exciting! The ABIM @abimcert.bsky.social w/the Accreditation Council for Continuing Medical Education has expanded the # of activities for which physicians can earn MOC credits.
🎙️ Hear more from leaders at ACCME and ABIM in their recent podcast conversation: lnkd.in/gQQDZQhy @drjunejd.bsky.social

Congratulations to my dear friend and colleague Dr David Bentrem! @luriecancer.bsky.social A fantastic pancreatic surgeon, he has incomparable skills in the operating room and practices the art of medicine at the bedside…always prioritizing his patients needs @drjunejd.bsky.social

Cancer cells hijack neurons to promote their growth. Here (and how) neurons form pseudo-synapses to promote pancreatic cancer's growth cell.com/cancer-cell/...

Checkpoint inhibitors are the mainstay of cancer immunotherapy. Here's a new review article for the current state of the science and where we're headed www.science.org/doi/10.1126/...

Tumors hijack macrophages for iron supply to promote bone metastasis and anemia Tumor cells mimic erythroblasts by hijacking a specialized macrophage population for iron supply, thereby promoting metastasis through enhanced adaptation to hypoxia and contributing to anemia by impa...

Discovery of the number of ways cancer cell hijack other cells to promote their growth and spread keeps proliferating www.cell.com/cell/fulltex...

How can we reawaken the body’s own anti-viral defenses to fight brain cancer?

Delighted to share our new study where we now answer this question, led by the brilliant @alvarezprado.bsky.social who is now an independent PI at LIH Luxembourg 👏👏

#BrainTIME 🧠🦠🧪
🧵

www.sciencedirect.com/science/arti...

Cancer-derived mitochondria fuel fibroblasts to become pro-tumorigenic - Nature Cancer Cancer-associated fibroblasts represent a functionally diverse and heterogeneous entity within the solid tumor microenvironment. Mitochondrial transfer from cancer cells to fibroblasts is now shown to...

One more diabolical trick of cancer cells: transferring their mitochondria to fibroblasts to promote their growth
nature.com/articles/s43...

Long-term impacts of heatwaves on accelerated ageing - Nature Climate Change Ageing is linked to environmental factors. This study shows that although participants gradually adapted to heat over time, cumulative exposure to heatwaves had stable and adverse impacts on ageing, e...

Exposure to heat waves and accelerated biological aging
www.nature.com/articles/s41...

Plasma tau biomarkers for biological staging of Alzheimer’s disease - Nature Aging Montoliu-Gaya, Salvadó et al. develop a blood-based model using tau biomarkers measured in a single analysis enabling biological staging of Alzheimer’s disease to support the diagnosis, prognosis and ...

How plasma p-Tau markers can predict if and when there will be transition to mild cognitive impairment and Alzheimer’s disease in cognitively unimpaired individuals, along staging of the disease
www.nature.com/articles/s43...

Gero-onc matters. “Effectiveness of comprehensive geriatric assessment with extensive patient coaching for improving quality of life in older patients with solid tumours receiving systemic therapy (G-oncoCOACH): a multicentre randomised controlled trial” - The Lancet @drjunejd.bsky.social

A great review of what I’ll refer to as “glymphatic physiology.” As Cajal has said, “The brain is a world consisting of a number of unexplored continents and great stretches of unknown territory.” @drjunejd.bsky.social

Congratulations! Wishing you every success on this new journey, Dr Pennell @drjunejd.bsky.social

My mentee, Fares Siddig, is now a meritorious medical student at Columbia University Vagelos College of Physicians and Surgeons @columbiamed.bsky.social He is an outstanding young man w/ a bright future ahead. I can hardly wait to see the impact he will have on our profession @drjunejd.bsky.social

One in 4 people carry one copy of the APOE4 allele, the strongest known genetic risk factor for Alzheimer's disease. We've just learned how that risk is mediated—the immune system
erictopol.substack.com/p/our-braini...

UK gets first female Astronomer Royal in 350 years Prof Michele Dougherty is the first woman to be appointed to the influential post.

UK gets first female Astronomer Royal in 350 years.

Astronomer Prof Michele Dougherty CBE FRS FRAS did not study science in secondary school – but was instead inspired to learn more about space after using her father's telescope.

🧪🔭
www.bbc.co.uk/news/article...

Had a lovely time reconnecting with alumni and faculty from @uiccom
during NMA 2025 at the Blackstone. Catching up with Chicago treasures Urologist Dr Terry Mason, Chief Exec Provident Hospital Dr Arnold Turner, and Executive Director of UI Health Mile Square Dr Karriem Watson @drjunejd.bsky.social

Can AI help people stay healthier as they age by helping to predict disease? @peteratmsr.bsky.social and Dr. Eric Topol explore this and other topics in Episode 8 of “The AI Revolution in Medicine, Revisited.” msft.it/6019s6arx

We need a lot of “will” and “willingness” to take us beyond big pharma’s quest to transition cancer to a chronic disease versus finding cures and sharing them with humanity at a reasonable ROI @drjunejd.bsky.social

On the potential risk of gabapentin (Neurontin) for mild cognitive impairment and dementia
rapm.bmj.com/content/earl...

YouTube video by Amanpour and Company Could GLP-1s Fight Alzheimer's?

Preventing Alzheimer’s disease
With @walteri.bsky.social @amanpourcopbs.bsky.social
youtube.com/shorts/cLJOe...

FIT FOR SURGERY…
Pleased to share the results of our NIH-funded research study:

Fit4Surgery: A pilot randomized controlled trial to assess the feasibility of prehabilitation prior to debulking surgery for ovarian cancer

Link:
authors.elsevier.com/c/1lNVtKfi92...

@drjunejd.bsky.social

A great opportunity to work with an outstanding NIH-funded PI @drxu.bsky.social at Emory University! Don’t miss it! @drjunejd.bsky.social

With much restraint, I’ll simply state…Concerning! @drjunejd.bsky.social