Imogen Ramsden

Thanks for your comment @gavinmcstay.bsky.social, though this post was while travelling to YSF not of my experience there! I hope to post more on #YSF2025 and #FEBSCongress2025 when the congress is over.

Back to back conferences - having wrapped up the Small G proteins meeting, landed in Istanbul heading to the 24th FEBS Young Scientists’ Forum ( #YSF2025 ) held in the stunning region of Sapança!
Thanks to the FEBS for awarding me a YSF travel grant!

@febspress.bsky.social
#FEBS2025 #BiochemEvent

💬 Loved asking questions, learning from so many great discussions and connecting with scientists across different backgrounds. Thanks to @biochemsoc.bsky.social for organising such a brilliant #BiochemEvent!

That’s a wrap on Small G Proteins Meeting 2025!

🌟 Highlights:
💡 Insightful talks given by students, postdocs and PIs
❓ Q&A from ECRs encouraged (thanks for my honourable mention for participation!)
🧫 Broad cell biology topics and methodology
💊 Clinical perspectives alongside fundamental research

Final Session 6 SGP2025:
🎯 Biomechanical signatures & potential targets in cancer
🧬 Rho and Cdc42 regulation via PTMs, localisation & degradation in cancer and immunodeficiencies
⚙️ Nuclear force feedback loops via Rnd3 modulate actomyosin tension

@biochemsoc.bsky.social #BiochemEvent

Last day of the #SmallGproteins meeting, great evening last night meeting researchers in the field hearing about people’s journeys, and gave advice on expressing a phosphorylated GTPase.

Looking forward to Session 6 kicked off by @vickysanzmoreno.bsky.social!

@biochemsoc.bsky.social #BiochemEvent

SGP25 Sessions 4 & 5:
🧬 Lipid sensing, β-catenin, and phosphorylation reshape GTPase signalling
⚙️ Mechanical forces & trafficking: nuclear F-actin, actin-Rab27a, plexins, and COL1
⚡️Cancer cell adaptation through RhoA/NFAT, Rac1 SUMOylation, and KRAS rewiring
@biochemsoc.bsky.social #BiochemEvent

SGP25 Session 3:
⛓️ Tri-complex inhibitor as molecular glue for oncogenic RAS
💊 Combining inhibitors to combat KRAS-driven cancer
🎯 p120RasGAP molecular glue targeting RAS
🔢 Mathematical modelling to study RAS activity
🧐 RAS/RAL, Cdc42, RhoG, RAC1, EPAC2, RalGAP…
@biochemsoc.bsky.social #BiochemEvent

SGP25 Session 2 (Part 2):
🧬 RAP1GDS1 isoform regulates KRAS signalling & lysosomal function in lung adenocarcinoma
❓Oncogenic KRAS may not alter Akt/ERK pathways
☠️ p190RhoGAP paralogs show synthetic lethality in endometrial cancer

@biochemsoc.bsky.social #BiochemEvent

SGP25 Session 2 (Part 1):
⚙️ “Branchgetic” Ras mutations indicate effector selection
🔬 RAF biosensors to monitor acivity in live cells
💥 C2 domain boosts RasGAP activity
💊 RhoB-Ral complex a target for EGFR TK inhibition?
@biochemsoc.bsky.social #BiochemEvent

@biochemsoc.bsky.social

Day 2 of #SGP25 of to a great start with

✨ unpicking Ras effector binding in different tissues
✨ developing RAF based biosensors
✨ C2 domains and GAP functionality
✨ how RhoB and Ral affect EGFT therapy in lung cancer

@Biochemsoc #BiochemEvent

SGP25 Session 1 (Part 2):
🧫 Overcoming RAS resistance: biobanking & precision medicine
💊 Adaptive immunity could enhance KRAS inhibitor activity
🔬 Organoids reveal allele-specific tumour growth
💥 Plus ARL15, RhoGDI1, RalGEF, SOS1/2 & proteomics pipelines
@biochemsoc.bsky.social #BiochemEvent

SGP25 Session 1 (Part 1):
⛓️ Mapping KRAS interactomes in organoid models
🧬 Isoform-specific KRAS vulnerabilities: one mutation, big difference
🔬 Novel tool tracks Ras mutation dynamics in vivo
✨ And a reminder that clear science communication empowers patients!
@biochemsoc.bsky.social #BiochemEvent

Just kicking off at the Small G Proteins Meeting 2025 after lunch meeting scientists from all over the world - Barcelona, Connecticut, New York - and it’s encouraging to see a programme with both early career researchers and group leaders presenting!
@biochemsoc.bsky.social
#BiochemEvent

Excited to be selected as one of the Social Media Contributors at the #BiochemEvent Small G Proteins Meeting next week, thanks to @biochemsoc.bsky.social.
I look forward to hearing about and discussing the latest research in the area as well as presenting my own PhD work about Arf proteins!

Still thinking about my great experience at #Biologists100 — from my flash talk and poster, to the ECR session and insightful main talks, and all the chats in between!

Big thanks to @biologists.bsky.social & @bscb-official.bsky.social for the opportunity!
📸 Full post and photos on my LinkedIn