Victoria Hart

What happens to packed cells in a monolayer during mitosis? @rlawson954.bsky.social presented varying experiments investigating shape and force changes, cell-cell junctions, and mechanics in mitotic cells, suggesting important roles for keratin and desmosomes #MBIMPG2025 @helenkmatthews.bsky.social

Sheffield Pancreatic Cancer Research Network - Events Upcoming Events

Interested in Pancreatic Cancer Research? We are gearing up to host our 7th Sheffield Pancreatic Cancer Research Network meeting!

Check out the details at: sites.google.com/sheffield.ac...

@mcb-sheffield.bsky.social @fohsheffield.bsky.social

Two fantastic talks at the 6th Pancreatic Cancer Research Network meeting by Megan Poxon and @isabelladavis00.bsky.social . Fancy speaking at the next one? Just get in touch!

p.s. Don't forget to check out our new website 🔬https://sites.google.com/sheffield.ac.uk/pancreatic-cancer-network/home

Great talks by PhD students @isabelladavis00.bsky.social and Meg at the Sheffield Pancreatic Cancer Research Network meeting 👏

A beautiful day in the sunshine for our lovely lab summer social ☀️ @isabelladavis00.bsky.social @helenkmatthews.bsky.social @rlawson954.bsky.social

Last day of the #SmallGproteins meeting, great evening last night meeting researchers in the field hearing about people’s journeys, and gave advice on expressing a phosphorylated GTPase.

Looking forward to Session 6 kicked off by @vickysanzmoreno.bsky.social!

@biochemsoc.bsky.social #BiochemEvent

Now some adhesion and migration at #SGP25

🔬 hunting for Ras allies
🧫 polarised trafficking regulation adaptability during change
🧬 RhoA and Cdc42 pathway crosstalk

Now onto the party!

@biochemsoc.bsky.social #BiochemEvent

Now some adhesion and migration at #SGP25

🔬mechanosensing in cancer development
🧫 Rac1 driven plasticity in small cell lung cancer
🧬 actin in organelle transport
🧪 tool development to study spatial organisation of receptors

@biochemsoc.bsky.social #BiochemEvent

Moving to a translational space

🔬 how we can revitalise therapies in response to resistance to Ras inhibitors
🧫 Arf6 alters matrix for metastatic niche in ovarian cancer
🧬 Novel phosphorylation regulates Arfs
🧪 Rac1 involvement in breast cancer metastases
@biochemsoc.bsky.social #BiochemEvent

As day 3 of #SGP25 opens we heard brilliants talks covering…

🔬Ras lipid sensing to control localisation
🧫 Rnd3/RhoE importance in hepatocellular carcinoma
🔥 the role of Cdc42 in inflammation in response to wildfire smoke
🧪 the RhoA mutational landscape

@biochemsoc.bsky.social #BiochemEvent

Next, we look at how to target our small G proteins

🔬innovations in the targeting of Ras from Revolution Medicines
🧫 translating non-canonical functions of kRas to find targeting combinations
🧬 developing and testing a GAP glue
🧪 mutant and WT Ras crosstalk
@biochemsoc.bsky.social #BiochemEvent

As a side what a beautiful site for a conference, flowers everywhere in the sunshine ☀️
@biochemsoc.bsky.social #BiochemEvent

And we continue #SGP25 with

🔬RAP1GDS1 isoform specific importance in lung cancer

🧫 how kRas oncogenic enhanced proliferation can occur without hyperactive ERK or Akt

🧬 RhoGAP family interactions in endometrial cancer

@biochemsoc.bsky.social #BiochemEvent

SGP25 Session 2 (Part 1):
⚙️ “Branchgetic” Ras mutations indicate effector selection
🔬 RAF biosensors to monitor acivity in live cells
💥 C2 domain boosts RasGAP activity
💊 RhoB-Ral complex a target for EGFR TK inhibition?
@biochemsoc.bsky.social #BiochemEvent

Day 2 of #SGP25 of to a great start with

✨ unpicking Ras effector binding in different tissues
✨ developing RAF based biosensors
✨ C2 domains and GAP functionality
✨ how RhoB and Ral affect EGFT therapy in lung cancer

@Biochemsoc #BiochemEvent

SGP25 Session 1 (Part 1):
⛓️ Mapping KRAS interactomes in organoid models
🧬 Isoform-specific KRAS vulnerabilities: one mutation, big difference
🔬 Novel tool tracks Ras mutation dynamics in vivo
✨ And a reminder that clear science communication empowers patients!
@biochemsoc.bsky.social #BiochemEvent

Excited to be selected as a Social Media Contributor for Small G proteins in cellular signalling and disease 2025! 🧬

Follow along for insights into how these tiny but mighty proteins shape health and disease!

#BiochemEvent @BiochemSoc #SmallGProteins #CellBiology #SciComm

Sheffield Pancreatic Cancer Research Network Meet the Team

I am excited to share our new Sheffield Pancreatic Cancer Research Network website! Please check it out at... sites.google.com/sheffield.ac... @fohsheffield.bsky.social @mcb-sheffield.bsky.social

A brilliant talk that sparked great discussions!

Great to hear about the research going on in @mcb-sheffield.bsky.social at University of Sheffield. Short talks from @helenkmatthews.bsky.social and @erainerolab.bsky.social about the projects going on in their labs 😊

loved having to opportunity to discuss our work and have plenty of great suggestions! #biologists100

Excited to be in the lovely Liverpool for the 100 year anniversary of the @biologists.bsky.social.